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UTHealth, BCM researchers find common gene variant associated with aortic dissection
Date:9/11/2011

HOUSTON (Sept. 11, 2011) Richard Holbrooke, John Ritter, Lucille Ball, Jonathan Larson and Great Britain's King George II were all taken by the same silent killer: an acute aortic dissection.

Now, scientists led by researchers at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine (BCM) have found an association with a common genetic variant in the population that predisposes people to acute dissections and can approximately double a person's chances of having the disease.

An aortic aneurysm is an enlargement or ballooning of the aorta in the segment where it comes out of the heart (thoracic aortic aneurysm). The natural history of a thoracic aortic aneurysm is to enlarge without symptoms over time, leading to instability of the aorta and ultimately an acute aortic dissection. The dissection is a tear in the aorta that allows blood to flow within its layers. It is a life-threatening event, with up to 40 percent of patients dying suddenly.

Although the average age of a person who suffers an aortic dissection is early 60s, the disease can strike at any age. Since the majority of individuals have an aortic aneurysm prior to dissection, identification of these aneurysms is critical since the aneurysm can be surgically repaired to prevent the aortic dissection, which typically occurs when the diameter of the aneurysm reaches twice that of the normal aorta. Therefore it is important to know who is at risk for this disorder.

The results of the research are published in the Sept. 11, 2011 advance online issue of Nature Genetics. Senior author is Dianna M. Milewicz, M.D., Ph.D., professor and the President George H.W. Bush Chair in Cardiovascular Research at The University of Texas Medical School at Houston, part of UTHealth.

"This is the first time we've found an association with a common genetic variant in the population that predisposes people to thoracic aortic
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Contact: Deborah Lake
deborah.m.lake@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

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UTHealth, BCM researchers find common gene variant associated with aortic dissection
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