Navigation Links
UTHealth, Athersys preclinical research on stem cell therapy for stroke presented at AHA conference
Date:2/10/2011

owever, tPA must be administered within several hours from when the stroke has occurred in order to be effective. Due to its limited window, only about 5% of all patients who could potentially benefit from therapy with tPA actually receive treatment. Given the lack of effective therapies, many patients who suffer a stroke require extensive physical therapy or experience significant or permanent disability, and as a result, must receive long-term institutional care or be cared for by a family member. As a consequence of an aging population, recent forecasts from the American Heart Association project that the prevalence of stroke will increase by 25% in the next 20 years, and the total estimated annual cost for treating and caring for stroke survivors will skyrocket from $64 billion in 2010 to $140 billion in 2030, representing a substantial increase in cost to the national healthcare system.

In the rat model of stroke used in the study, animals that received treatment with MultiStem showed statistically significant improvement in motor skills relative to animals that received placebo, and also showed reduced cell death, reduction of inflammatory cytokines and an increase in anti-inflammatory cytokines. Interestingly, researchers found that animals treated with placebo showed a reduction in spleen size and an increase in inflammatory cytokines in the blood, whereas animals that were treated with MultiStem showed normal spleen size and increased levels of anti-inflammatory cytokines in the blood. The spleen is believed to play a significant role in promoting and sustaining the inflammation that can result in substantial long-term damage following brain injury.

"Ischemic stroke represents an enormous clinical, economic and social burden that is expected to increase dramatically in the years ahead as a result of an aging population, and the corresponding increase in the number of individuals that are susceptible to all forms of cardiovascular
'/>"/>

Contact: Deborah Mann Lake
deborah.m.lake@uth.tmc.edu
University of Texas Health Science Center at Houston
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UTHealth, BioHouston sign collaborative agreement
2. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
3. Cell-enriched fat grafts improve long term graft retention in preclinical study
4. TNO and Seventh Wave sign letter of intent on joint preclinical pharmaceutical outsourcing services
5. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
6. Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers
7. Versartis presents positive preclinical data on 2 product candidates at ENDO 09
8. REGiMMUNE presents enhanced efficacy data in preclinical transplantation models
9. Preclinical work shows how one gene causes severe mental retardation
10. Pulmonary fibrosis inhibited by pentraxin-2/SAP in research study
11. New evolutionary research disproves living missing link theories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Museum will present the prestigious Parker/Gentry Award to Mr. ... biodiversity conservation awareness. The Parker/Gentry Award is given annually ... or organization whose efforts have had a significant impact ... actions can serve as a model to others. , ... science and conservation news website that draws more than ...
(Date:9/2/2014)... BETHESDA, MD The American Society of Human ... Institute (NHGRI), part of the National Institutes of ... School Science Teacher at The Wellington School in ... Fellow. The 16-month appointment begins today. , The ... early-career genetics professionals expand their skills, experience, and ...
(Date:9/2/2014)... It,s not always true that digital distribution of ... by physical means, at least when file sizes ... study published in Yale,s Journal of Industrial ... of games for consoles such as PlayStation3. Researchers ... caused lower greenhouse gas emissions than game files ...
Breaking Biology News(10 mins):ASHG and NHGRI award first genetics and education fellowship 2
... (NREL) is working with Ecopetrol, the largest oil company ... and palm oil harvesting into fuel ethanol for blending ... (CRADA) between NREL and Ecopetrol aims to optimize the ... the sugars are removed from the sugar cane) and ...
... WASHINGTON D.C. August 13, 2013 -- Adjacent to the walls of ... up our microcirculation -- there exists a peculiar thin layer of ... a few millionths of a meter thick, that layer is vital. ... the site of a cut and start the clotting process. ...
... brightly coloured crowns are better mothers than duller birds, according ... , Unlike humans, birds can see ultra-violet (UV) light. While ... us, to another bird it has the added dimension of ... also involved researchers from the University of California Davis, USA ...
Cached Biology News:NREL and Colombian oil firm unlocking agricultural waste feedstocks for biofuel 2NREL and Colombian oil firm unlocking agricultural waste feedstocks for biofuel 3Computer model predicts red blood cell flow 2Bright birds make good mothers 2
(Date:9/2/2014)... of a meter in size, are around us every ... health, as in some innovative early cancer treatments, but ... pollution, traffic emissions, cosmetics, sunscreen and electronics. , A ... led by Lan Yang, PhD, the Das Family Career ... their collaborators at Tsinghua University in China have developed ...
(Date:9/2/2014)... Sept. 2, 2014  TransCelerate BioPharma Inc. ("TransCelerate") ... approach for protecting personal data in Clinical Study ... and others. The document describes an approach to ... CSRs and other related clinical trial documents, and ... goal of the TransCelerate CSR Redaction approach is ...
(Date:9/2/2014)... Calif. , Sept. 2, 2014  Xencor, ... biopharmaceutical company developing engineered monoclonal antibodies for the ... and cancer, today announced the appointment of ... development and the appointment of Lloyd Rowland ... general counsel. "Debra,s expertise in ...
(Date:9/2/2014)... Md. , Sept. 2, 2014  Spherix Incorporated ... and monetization of intellectual property, today announced that the ... patents to the Company in the month of August ... patents.  The issued patents are: ... , U.S.RE45,081 issued August 19, 2014; and , ...
Breaking Biology Technology:Engineers develop new sensor to detect tiny individual nanoparticles 2Engineers develop new sensor to detect tiny individual nanoparticles 3TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 3Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2
... connecting bones to muscles that raise an eyebrow or propel ... unusually forceful or awkward pull on the strings leaves us ... repair over 300,000 of these injuries every year, and doctors ... Using a combination of nanoscience and biomedical and civil engineering ...
... long a standard tool in biomedical research and diagnostic ... to new electronic biosensing technology developed by a team ... Institute of Technology. Essentially arrays of tiny test ... test multiple samples for their responses to chemicals, living ...
... Advisors LLC, a subsidiary of Ramius LLC (collectively, "Ramius"), today ... has denied Ramius, legitimate request for a list of the ... has launched a tender offer to purchase all of the ... in cash.  Ramius requested the stockholder list materials in accordance ...
Cached Biology Technology:The Achilles' heel of tendons 2The Achilles' heel of tendons 3Novel electronic biosensing technology could facilitate new era of personalized medicine 2Novel electronic biosensing technology could facilitate new era of personalized medicine 3Novel electronic biosensing technology could facilitate new era of personalized medicine 4Cypress Denies Ramius' Legal Right to Stockholder List Materials 2Cypress Denies Ramius' Legal Right to Stockholder List Materials 3
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... is a high performance spectral scanning ... incubator. With the advanced SkanIt Software ... for drug discovery assay development. Varioskan ... intensity, time-resolved fluorescence and photometric assays ...
... series of refrigerated cold traps offers a ... low volatility/aqueous solvents or high volatility solvents. ... vacuum concentrators/centrifugal evaporators. Also used for maintaining ... as used in electron microscopes. Can be ...
Black 96 Well Plate EB, RE Bottom...
Biology Products: