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UT to develop fracture putty for traumatic leg injuries
Date:1/26/2009

aling process as quickly as possible is good for the patient," said John Holcomb, M.D., a retired U.S. Army Surgeon who now heads the Center for Translational Injury Research at the UT Health Science Center at Houston. "This could reduce the risk of infection and the onset of complications."

The DOD agency funding the project, the Defense Advanced Research Projects Agency (DARPA), sponsors revolutionary high-risk, high-payoff research that bridges the gap between fundamental discoveries and their military and civilian use. DARPA Program Manager Mitchell Zakin, Ph.D., said: "This undertaking represents the ultimate convergence of materials science, mechanics and orthopedics. I look forward to the first results, which should present themselves in about a year or so."

Ennio Tasciotti, Ph.D., a research assistant professor in Ferrari's lab, said the putty will include a material called nanoporous silicon that was developed in Ferrari's lab, which will give the putty the strength it needs to support the patient's weight while new bone tissue is being regenerated.

Developing a new way to repair long bone injuries is extremely challenging. According to Tasciotti, "This problem will require the contributions of a team of the best scientists in the fields of nanoporous silicon, bio-mimetic peptides, bio-polymers, stem cells and adhesives. The solution will come from the integration of nanomaterials with unique properties in a smart composite substance that can mimic bone structure and function."

He added, "The fracture putty will serve as a bioactive scaffold and will be able to substitute for the damaged bone. At the same time, the putty will facilitate the formation of natural bone and self-healing in the surrounding soft tissue through the attraction of the patient's own stem cells. The putty will have the texture of modeling clay so that it can be molded in any shape in order to be used in many different surgical applications includi
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Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

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