Navigation Links
UT to develop fracture putty for traumatic leg injuries
Date:1/26/2009

Biomedical engineers at The University of Texas Health Science Center at Houston are leading a multi-institution initiative to produce a bio-compatible compound designed to mend serious leg fractures.

The researchers have been awarded $5.2 million in initial funding from the U.S. Department of Defense to develop "fracture putty" that could be used to regenerate bones shattered by roadside bombs or other explosive devices. This type of injury is called a non-union fracture and generally will not heal in a timely manner. It can lead to amputation. The total value of the effort, if all phases of the development program are completed, could be up to $7.9 million.

Serious leg injuries typically are repaired with bone grafts. Pins, plates or screws hold the grafts to healthy bone and external fixators provide support. Soldiers may require multiple surgeries and recuperation periods of about a year. And, they may not recoup full use of the injured leg.

If fracture putty proves successful, injured soldiers could fundamentally regain full use of their legs in a much shorter period of time. It could also be used in emergency rooms to treat civilians injured in traffic accidents and other traumatic events, said Mauro Ferrari, Ph.D., principal investigator and deputy chairman of the Department of Biomedical Engineering, a joint venture among the UT Health Science Center at Houston, The University of Texas at Austin and The University of Texas M. D. Anderson Cancer Center.

"Success on even a small part of the project has the potential to revolutionize orthopedic medicine. It could give people with serious leg injuries an opportunity to regain full use of limbs that now require amputations or the use of permanent implants," Ferrari said. "We're creating a living material that can be applied to crushed bones. The putty will solidify inside the body and provide support while the new bone grows."

"Anything you can do to start the healing process as quickly as possible is good for the patient," said John Holcomb, M.D., a retired U.S. Army Surgeon who now heads the Center for Translational Injury Research at the UT Health Science Center at Houston. "This could reduce the risk of infection and the onset of complications."

The DOD agency funding the project, the Defense Advanced Research Projects Agency (DARPA), sponsors revolutionary high-risk, high-payoff research that bridges the gap between fundamental discoveries and their military and civilian use. DARPA Program Manager Mitchell Zakin, Ph.D., said: "This undertaking represents the ultimate convergence of materials science, mechanics and orthopedics. I look forward to the first results, which should present themselves in about a year or so."

Ennio Tasciotti, Ph.D., a research assistant professor in Ferrari's lab, said the putty will include a material called nanoporous silicon that was developed in Ferrari's lab, which will give the putty the strength it needs to support the patient's weight while new bone tissue is being regenerated.

Developing a new way to repair long bone injuries is extremely challenging. According to Tasciotti, "This problem will require the contributions of a team of the best scientists in the fields of nanoporous silicon, bio-mimetic peptides, bio-polymers, stem cells and adhesives. The solution will come from the integration of nanomaterials with unique properties in a smart composite substance that can mimic bone structure and function."

He added, "The fracture putty will serve as a bioactive scaffold and will be able to substitute for the damaged bone. At the same time, the putty will facilitate the formation of natural bone and self-healing in the surrounding soft tissue through the attraction of the patient's own stem cells. The putty will have the texture of modeling clay so that it can be molded in any shape in order to be used in many different surgical applications including the reconnection of separated bones and the replacement of missing bones."

Tasciotti said the fracture putty could one day be used to address injuries involving the spine, skull and facial bones. "The findings of this research could eventually benefit all the victims of any bone-related traumatic injury and reduce the number of wartime amputations in the military as well the civilian population," he said.

"The technology to be explored through this research presents the potential to revolutionize the treatment of bone fractures, both in civilian clinics and on the battlefield," said Rice University investigator Antonios Mikos, Ph.D., the J.W. Cox Professor in Bioengineering, professor of chemical and biomolecular engineering and the director of Rice's Center for Excellence in Tissue Engineering. He is collaborating on the project.

If the fracture putty works in an animal model, the next step would involve patients. "We have been in preliminary conversations with the U.S. Food and Drug Administration, and it appears that fracture putty may be classified as a combination product, with the primary mode of action being that of a drug," Ferrari said.

Ferrari's colleagues at the UT Health Science Center at Houston on the project include: Paul Simmons, Ph.D., director of the Centre for Stem Cell Research at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases; Mark Wong, D.D.S., associate professor and chairman of the Department of Oral and Maxillofacial Surgery at the University of Texas Dental Branch at Houston and professor in the Division of Oral and Maxillofacial Surgery at The University of Texas Medical School at Houston; Nagi Demian, M.D., D.D.S., assistant professor at the UT Dental Branch; Paolo Decuzzi, Ph.D., associate professor of health informatics at The University of Texas School of Health Information Sciences at Houston; and Milos Kojic, Ph.D., visiting professor of health informatics at UT School of Health Information Sciences and senior research scientist in the Department of Environmental Health at Harvard School of Public Health.


'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related biology news :

1. Compromised skin barrier function plays a role in psorasis development
2. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
3. Scripps scientists develop first examples of RNA that replicates itself indefinitely
4. NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays
5. Developer of advanced computing memory, father of biochemical engineering, and innovative engineering educators win highest engineering honors of 2009
6. Salk researchers develop novel glioblastoma mouse model
7. MIT develops new way to fuse cells
8. Nutrigenomics -- developing personalized diets for disease prevention
9. Web-based case studies help students develop career skills
10. UC San Diego and Genentech scientists develop potentially disruptive antibody sequencing technology
11. Real-time gene monitoring developed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
Breaking Biology Technology: