UT scientists discover link between protein and lu... (disease and emphysema said Richard J. C...)

UT scientists discover link between protein and lung disease

Date:9/15/2009

disease and emphysema," said Richard J. Castriotta, M.D., professor and director of the Pulmonary, Critical Care and Sleep Medicine Division at the UT Medical School at Houston and medical director of the Sleep Disorder Center at Memorial Hermann - Texas Medical Center.

The study stems from research in Blackburn's laboratory involving a signaling molecule named adenosine, which can orchestrate the process of inflammation in wound healing. Adenosine can also activate a cell surface receptor associated with COPD named A2B and produce osteopontin.

Blackburn's decade-long research has focused on blocking the A2B receptor. With the new study linking osteopontin to COPD, Blackburn believes his laboratory may have uncovered a protein that could lead to a more targeted approach to treating emphysema.

"As a physician scientist, one goal of drug development is to offer more specific drug targets to treat the disorder and osteopontin provides a specific target that may be associated with fewer side effects," Schneider said.

"This paper adds a new element, osteopontin, to the mix by discovering its significant role in the development of COPD with emphysema ... It's still too early to be used clinically, but there may be a place for osteopontin in the future as an indicator of lung disease in progress that leads to COPD and emphysema," Castriotta said.

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Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

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UT scientists discover link between protein and lu...(disease and emphysema said Richard J. C...)