Navigation Links
UT scientist receives hemophilia research award
Date:7/2/2009

Keri Smith, Ph.D., an assistant professor of pathology and laboratory medicine at The University of Texas Health Science Center at Houston, has received a Career Development Award from the National Hemophilia Foundation.

The award will support Smith's research into the development of a therapy for people with Hemophilia A, a bleeding disorder, whose immune systems are resistant to treatment. Hemophilia A affects about one in every 5,000 males born in the United States.

Through the award, Smith is eligible for up to $70,000 per year for a maximum of three years. The National Hemophilia Foundation is a nonprofit organization founded in 1948 to find cures for bleeding disorders.

People with Hemophilia A are born with a shortage of a blood-clotting protein called Factor VIII and current treatments include injections of synthetically-produced, replacement Factor VIII. Symptoms include uncontrolled, sometimes unprompted bleeding.

Nearly one in three people with Hemophilia A have immune systems that are resistant to replacement Factor VIII and produce antibodies that attack the synthetic protein. "Current therapies to treat these antibodies are expensive and often unsuccessful," Smith said.

Smith's solution is to alter the chemical signals produced by T cells that trigger the production of the anti-Factor VIII antibodies in people with Hemophilia A, which in turn would make people with the disease more receptive to the replacement protein.

"The real advances in science often occur at the interface between two different fields," said Steven J. Norris, Ph.D., Robert Greer Professorship in the Biomedical Sciences and vice chair for research in the Department of Pathology and Laboratory Medicine at The University of Texas Medical School at Houston. "In this case, Dr. Smith has applied her expertise in T cells and their role in inflammatory reactions to an important problem in the treatment of hemophilia with Factor VIII. She will first look for inflammatory responses to Factor VIII, and then see if they can be blocked by using a novel protein that inhibits such responses. This approach may decrease the occurrence of inhibitory antibodies that often interfere with an otherwise effective treatment for hemophilia."

Smith's hemophilia research also received support through the Center for Clinical and Translational Sciences at the UT Health Science Center. Smith completed her undergraduate work at The University of Delaware, her doctorate at Montana State University and her postdoctoral training at The University of Michigan.


'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the world-leading ... and publication industries, will provide the data management solution ... (NPSC). ... Phenotypic analysis measures the ... organisms, allowing comparisons between states such as health and ...
(Date:1/21/2016)... India , January 21, 2016 ... According to a new market research report "Emotion Detection ... and Others), Software Tools (Facial Expression, Voice Recognition ... Regions - Global forecast to 2020", published by ... is expected to reach USD 22.65 Billion by ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
Breaking Biology News(10 mins):
(Date:2/11/2016)...  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) today announced its ... --> --> For the ... $29.3 million, or $0.34 loss per share, compared to a net ... same period in 2014. For the year ended December 31, 2015, ... loss per share, as compared to a net loss of $60.5 ...
(Date:2/11/2016)... ATLANTA , Feb. 11, 2016  Wellcentive ... a Portland, Oregon -based community ... to provide population health analytics, quality reporting and ... help FamilyCare strengthen its team of quality managers, ... reporting to the provider groups serving FamilyCare members. ...
(Date:2/11/2016)... ... February 11, 2016 , ... Reichert Technologies, which has ... to pursue the highest level of accuracy and quality with the addition of ... the AR5 Refractometer. Accurate, reliable and tough enough for the most demanding ...
(Date:2/10/2016)... , Feb. 10, 2016  The Maryland House ... , has announced that University of Maryland School of ... MBA and University of Maryland Medical System President and ... the "Speaker,s Medallion," the highest honor given to the ... Delegates. Dean Reece and Mr. Chrencik ...
Breaking Biology Technology: