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UT Southwestern's Mangelsdorf elected to National Academy of Sciences
Date:4/29/2008

sensors in protecting human cells against unusually high and possibly toxic levels of lipids, such as cholesterol and fatty acids. He has discovered several new molecules, called ligands, that activate so-called orphan nuclear receptors. Dr. Mangelsdorf has determined the critical role these receptors and ligands play in the regulation of lipid and bile acid metabolism and the governance of cholesterol, which could lead researchers to the development of new drugs to fight high cholesterol and related diseases.

David and his co-workers have contributed major insights to the understanding of lipid metabolism, especially cholesterol metabolism, said Dr. Alfred Gilman, provost, executive vice president for academic affairs and dean of UT Southwestern Medical School. Mike Brown and Joe Goldstein made huge contributions to the knowledge of cholesterol synthesis and disposition. David Mangelsdorf discovered the rest, and it was much more interesting and important than anyone anticipated.

Interestingly, Dr. Mangelsdorf said he had not expected to study cholesterol or bile acids when he first came to Dallas.

As is often the case in scientific research, there was an element of serendipity in our discoveries, he said. You can imagine my delight and surprise that these discoveries were made at the same institution as the worlds experts in this field.

Dr. Gilman, Nobel laureate, fellow NAS member and Dr. Mangelsdorfs immediate predecessor as chairman of pharmacology at UT Southwestern, added, David has been a true citizen of the medical center. I was excited to recruit him to Dallas, thrilled to watch his career blossom, and proud that he is now my successor as chair of a wonderful Department of Pharmacology.

Dr. Kern Wildenthal, president of UT Southwestern, said, Election to the National Academy of Sciences is a tremendous honor that recognizes excellence in research and outstanding contributions to science. David Mangelsdorf epito
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Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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UT Southwestern's Mangelsdorf elected to National Academy of Sciences
UT Southwestern's Mangelsdorf elected to National Academy of Sciences
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