Navigation Links
UT Southwestern researchers probe kidney damage, protection in lupus
Date:4/20/2009

DALLAS April 21, 2009 Kidney damage associated with the autoimmune disease lupus is linked to a malfunction of immune cells that causes them to congregate in and attack the organs, researchers at UT Southwestern Medical Center have discovered in a mouse study.

In a separate study with an international team, the researchers also found that a certain set of genes appears to protect the kidneys from a different sort of immune attack in both mice and humans.

"These studies, taken together, uncover two important molecules that underlie the pathology of lupus, particularly kidney disease," said Dr. Edward Wakeland, chairman of immunology at UT Southwestern and co-senior author of the studies.

"In addition, they highlight a certain molecule as a potential target for treating this disease," he said.

In the first study, which appears in the April issue of The Journal of Immunology, the researchers examined several strains of mice that mimic human lupus. They found that immune cells in those mice overproduced a particular molecule called CXCR4. In fact, the mice had up to twice as much CXCR4 as their normal counterparts in several types of immune cells. The lupus-prone mice also had more immune-system cells in their kidneys, indicating that the inflammatory action of the immune cells might be causing the kidney damage.

The CXCR4 molecule was already known to play a role in creating various types of blood cells and also has been shown to be active in cancer and AIDS. Cells with CXCR4 on their surface are attracted to another molecule released by cells in various organs, so they migrate toward those organs, including the kidney.

When the researchers treated the lupus mice with a substance that blocks CXCR4, the symptoms of lupus significantly diminished; many symptoms of kidney failure were averted; and the mice lived longer. The increased lifespan was greater when treatment began at an early age.

<
'/>"/>
Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
2. Two UT Southwestern researchers awarded Sloan fellowships
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
5. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
6. UT Southwestern scientist honored among best in Texas research
7. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
8. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
9. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
10. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
11. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... with traumatic injuries have identified an immune marker ... a hospital-acquired infection. The study, led by clinician-scientists ... June in the journal Shock , is ... to the clinical implementation of quick-turnaround immune function ... system damage following critical illness or injury in ...
(Date:7/9/2014)... shark species may be able to cope with the rising ... , The Arctic today is best known for its tundra ... Roughly 53 to 38 million years ago during what is ... to a huge temperate forest with brackish water, home to ... creatures, crocodiles and giant tortoises. Much of what is known ...
(Date:7/9/2014)... U.S. may be on the verge of an economy driven ... cleaner than coal and is undergoing a production boom. It ... but recent research is casting serious doubts over just how ... & Engineering News (C&EN), the weekly news magazine of ... a senior correspondent at C&EN, explains that when burned as ...
Breaking Biology News(10 mins):Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3
... SLOVENIARidge and furrow rainwater-harvesting (RFRH) systems with mulches were ... northwest China to improve water availability and to increase ... rainwater harvesting zones, and bare or mulched furrows serve ... and are being promoted in many parts of the ...
... that can cope with sudden fluctuations in the weather could ... of plants. Scientists studying how tiny algae renew ... useful in developing crops suited to climates in which weather ... protein renewal takes place dictates how quickly they can adapt ...
... A manmade package filled with nature,s bone-building ingredients delivers ... bone injuries faster than products currently available, Cleveland researchers ... surgical elastic "implant device," essentially a wrapping that mimics ... growth factors and other natural components of the periosteum ...
Cached Biology News:Improved rainwater harvesting system promising 2It's all in the wrapping 2
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility ... of Product Strategy. In this role, Michelle will work with ... guide in the development of iLab products. Her main goal ... benefit to the scientific community by offering the most advanced, ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... - Tamiflu Remains Fully Effective ... Latest surveillance data coming through ... virologists and clinicians indicates that,the influenza A(H3N2) virus is ... on the data published by ECDC Roche confirms that ...
... Conn., Jan. 19 SurgiQuest, Inc. is pleased to ... agreement with Intuitive Surgical, Inc. (Nasdaq: ISRG ... system using AirSeal(TM) technology for use with Intuitive,s laparoscopic ... invasive surgical procedures because it allows the surgeon to ...
... Corporation,s (Amex: ETC ) ("ETC" or ... of two BARA-MED(R) XD Monoplace Hyperbaric Chambers for ... St. Luke,s Hospital - Allentown Campus is part ... a nationally recognized, regional, integrated network of non-profit ...
Cached Biology Technology:Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 2Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 3Seasonal Influenza Activity Increasing Across Europe - H3N2 Dominant Strain 4SurgiQuest Signs a Development and Supply Agreement with Intuitive Surgical for MIS Access Utilizing the AirSeal(TM) Technology 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 3Environmental Tectonics Corporation Announces the Sale of Two BARA-MED(R) XD Monoplace Hyperbaric Chambers 4
Goat polyclonal to Rabenosyn 5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: ELKHTLAKQKGGTD, corresponding to C terminal amino acids 771-784 of Human Rabenosyn 5. Entr...
Acetyl CoA Carboxylase Antibody...
Anti-Human IFN-Gamma Receptor Chain 2 (beta chain) [CD119], Rabbit serum, NON-neutralizing polyclonal antibody...
AANAT [Arylalkylamine N-acetyltransferase; EC 2.3.1.87]...
Biology Products: