Navigation Links
UT Southwestern researchers probe kidney damage, protection in lupus
Date:4/20/2009

DALLAS April 21, 2009 Kidney damage associated with the autoimmune disease lupus is linked to a malfunction of immune cells that causes them to congregate in and attack the organs, researchers at UT Southwestern Medical Center have discovered in a mouse study.

In a separate study with an international team, the researchers also found that a certain set of genes appears to protect the kidneys from a different sort of immune attack in both mice and humans.

"These studies, taken together, uncover two important molecules that underlie the pathology of lupus, particularly kidney disease," said Dr. Edward Wakeland, chairman of immunology at UT Southwestern and co-senior author of the studies.

"In addition, they highlight a certain molecule as a potential target for treating this disease," he said.

In the first study, which appears in the April issue of The Journal of Immunology, the researchers examined several strains of mice that mimic human lupus. They found that immune cells in those mice overproduced a particular molecule called CXCR4. In fact, the mice had up to twice as much CXCR4 as their normal counterparts in several types of immune cells. The lupus-prone mice also had more immune-system cells in their kidneys, indicating that the inflammatory action of the immune cells might be causing the kidney damage.

The CXCR4 molecule was already known to play a role in creating various types of blood cells and also has been shown to be active in cancer and AIDS. Cells with CXCR4 on their surface are attracted to another molecule released by cells in various organs, so they migrate toward those organs, including the kidney.

When the researchers treated the lupus mice with a substance that blocks CXCR4, the symptoms of lupus significantly diminished; many symptoms of kidney failure were averted; and the mice lived longer. The increased lifespan was greater when treatment began at an early age.

<
'/>"/>
Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
2. Two UT Southwestern researchers awarded Sloan fellowships
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
5. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
6. UT Southwestern scientist honored among best in Texas research
7. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
8. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
9. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
10. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
11. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... , May 27, 2015   ... medication safety systems and image documentation solutions ... of comprehensive, technologically-advanced automation solutions, is pleased ... integration. The Codonics® Safe Label System® (SLS), ... in conjunction with the Omnicell Anesthesia Workstation, ...
(Date:5/22/2015)... According to a new market research report ... by Software (Middleware, Databases), by Hardware (Cameras, Integrated Devices), ... - Global Forecast to 2020", published by MarketsandMarkets, Facial ... to $6.19 Billion by 2020, at a CAGR of ... and   43 Figures spread through 140 Pages and ...
(Date:5/20/2015)... OXFORD, Conn. , May 20, 2015 ... "Company") announces that its wholly owned subsidiary, 3D-ID LLC, ... contractor under Team Battelle for the biometrics technology portion ... Unrestricted Suite Contract from the Department of the Army. ... facial recognition products developed for government, law enforcement and ...
Breaking Biology News(10 mins):Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
... Francisco have launched a groundbreaking study to determine whether ... the most common congenital chest deformity, in the same ... chest, which is known medically as pectus excavatum, is ... to the breastbone. The deformed cartilage pulls the breastbone ...
... recurrent cancer of the central nervous system that occurs primarily ... a clinical trial at the University of California, San Francisco. ... is always fatal. Findings from a group of 12 ... effective in stimulating the patient’s immune system to attack ...
... that chimpanzees from West Africa were cracking nuts with ... years ago. The result suggests chimpanzees developed this behaviour ... was a trait inherited from our common ancestor. Julio ... the Noulo site in Cote d'Ivoire, the only known ...
Cached Biology News:Study to explore using magnets to correct 'sunken chest' 2Study to explore using magnets to correct 'sunken chest' 3UCSF brain tumor vaccine trial shows promising results 2UCSF brain tumor vaccine trial shows promising results 3The chimpanzee stone age 2
(Date:6/3/2015)... Typical racks for laboratory freezers are generally ... often taking up unnecessary room in already crowded freezers. ... Box Freezer Racks offer a customizable storage solution ... boxes and freezers. , “These racks are perfect ... multiple people because users can configure freezer space to ...
(Date:6/3/2015)... Green Earth Energy has restructured their ... the RCBC Waste to Energy system. Paul Douglas ... family business, http://www.greenearthwaste.com which has been operating ... recycling to their waste collection services in 2012 and ... Fortune 500 companies with manufacturing plants in West Tennessee. ...
(Date:6/3/2015)... REYKJAVIK, Iceland , June 3, 2015   ... genome to improve health worldwide, today announced that it ... to provide clinical interpretation of the whole genome sequences ... of the first phase of the 100,000 Genomes Project ... WuXi NextCODE will deploy its unique database ...
(Date:6/3/2015)... June 03, 2015 Global Stem ... Inc. have announced plans to conduct Romania’s first ever ... Through an alliance with Miami-based Stem Cell Training, Inc., ... the Adipose and Bone Marrow Stem Cell Training Course ... reconstructive plastic surgery specialist practicing in Bucharest and Tel ...
Breaking Biology Technology:Freezer Space Can Now Be Configured Your Way with New Modular Freezer Racks 2WuXi NextCODE Wins Genomics England Clinical Interpretation Tender in both Rare Disease and Cancer 2Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 2Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 3
... Jersey, October 29, Rosetta Genomics Ltd. (Nasdaq: ROSG ... announced today its,management will present at Oppenheimer 19th ... the Waldorf-Astoria Hotel in New York,City., About ... occurring, small,RNAs that act as master regulators and ...
... /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), a vaccine-focused ... scheduled to present at two upcoming investor conferences, ... York City and the,Credit Suisse Asian Healthcare Conference ... Financial Manager, is scheduled to present on,Tuesday, November ...
... Osteotech, Inc.,(Nasdaq: OSTE ), a leader ... healing, announced today that it has received 510(k) ... ("FDA") for its next,generation grafting material. Osteotech received ... substitute, and as a bone void filler, for ...
Cached Biology Technology:Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 2Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 3Sinovac to Participate in Two Upcoming Investor Conferences 2Osteotech Receives FDA Clearance for its Next Generation Grafting Material 2