Navigation Links
UT Southwestern researchers probe kidney damage, protection in lupus
Date:4/20/2009

DALLAS April 21, 2009 Kidney damage associated with the autoimmune disease lupus is linked to a malfunction of immune cells that causes them to congregate in and attack the organs, researchers at UT Southwestern Medical Center have discovered in a mouse study.

In a separate study with an international team, the researchers also found that a certain set of genes appears to protect the kidneys from a different sort of immune attack in both mice and humans.

"These studies, taken together, uncover two important molecules that underlie the pathology of lupus, particularly kidney disease," said Dr. Edward Wakeland, chairman of immunology at UT Southwestern and co-senior author of the studies.

"In addition, they highlight a certain molecule as a potential target for treating this disease," he said.

In the first study, which appears in the April issue of The Journal of Immunology, the researchers examined several strains of mice that mimic human lupus. They found that immune cells in those mice overproduced a particular molecule called CXCR4. In fact, the mice had up to twice as much CXCR4 as their normal counterparts in several types of immune cells. The lupus-prone mice also had more immune-system cells in their kidneys, indicating that the inflammatory action of the immune cells might be causing the kidney damage.

The CXCR4 molecule was already known to play a role in creating various types of blood cells and also has been shown to be active in cancer and AIDS. Cells with CXCR4 on their surface are attracted to another molecule released by cells in various organs, so they migrate toward those organs, including the kidney.

When the researchers treated the lupus mice with a substance that blocks CXCR4, the symptoms of lupus significantly diminished; many symptoms of kidney failure were averted; and the mice lived longer. The increased lifespan was greater when treatment began at an early age.

<
'/>"/>
Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
2. Two UT Southwestern researchers awarded Sloan fellowships
3. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
4. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
5. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
6. UT Southwestern scientist honored among best in Texas research
7. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
8. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
9. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
10. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
11. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... consequences of removing infant chimpanzees from their mothers are ... of this type of early life experience. In a ... chimpanzees and concluded that those who were removed from ... as pets or performers are likely to show behavioral ... project, published today in the open-access journal PeerJ ...
(Date:9/22/2014)... New Haven, Conn. Yale University researchers are studying ... pulmonary fibrosis, a respiratory disease in which scars develop ... treatment uses a microRNA mimic, miR-29, which is delivered ... only blocked pulmonary fibrosis, it reversed fibrosis after ... in the journal EMBO Molecular Medicine . , ...
(Date:9/22/2014)... molecular cog in a plant,s biological clock one ... on temperature. , Transcription factors, or genetic switches, drive ... such as light, rain, soil quality, or even animals ... has isolated one, called FBH1, that reacts to temperature ... while in keeping it on a consistent track. , ...
Breaking Biology News(10 mins):Chimpanzees raised as pets or performers suffer long-term effects on their behavior 2Reversing the effects of pulmonary fibrosis 2Genetic switch regulates a plant's internal clock based on temperature 2
... been considered an exclusively human activity, but now at least ... for tomorrow. The finding also raises the intriguing possibility that, ... published today (22 February) in the journal Nature shows that ... by caching food. The birds are shown to have learned ...
... steak or chicken fillet every now and again could add ... shown for the first time that food enriched with natural ... processes of ageing. The concept has been demonstrated in worms ... human life and reduce the risk of cancer and other ...
... a visual display "shout" to get their point across, UC ... of their territory by sitting up on a tree trunk, ... throat pouch. They can spot a rival lizard up to ... UC Davis who is working with Judy Stamps, professor of ...
Cached Biology News:Birds found to plan for the future 2Meat and two neutrons -- the key to a longer life 2
(Date:9/23/2014)... (PRWEB) September 23, 2014 Texas Fertility ... clinic in South Austin, expanding a Central Texas footprint ... San Antonio. The satellite office for the region’s most ... options to the South Austin, Buda, Kyle and San ... and affordable fertility treatment directly to individuals and couples ...
(Date:9/23/2014)... Albany, New York (PRWEB) September 23, 2014 ... advocates from around the globe will convene ... 11th International Conference, to be held October ... latest in evidence-based research and practice in ... includes physicians, scientists, researchers, nurses, psychologists, nutritionists, ...
(Date:9/22/2014)... OAKLAND, Calif., September 22, 2014 Patients who were treated ... a hemorrhagic stroke were significantly more likely to survive ... published today in JAMA Neurology . This study ... that the use of cholesterol-lowering statins can improve survival ... by a constriction or obstruction of a blood vessel ...
(Date:9/22/2014)... Research and Markets ( ... "Global Biotechnology Reagents Market 2014-2018" report ... Biotechnology reagents are chemical compounds or ... detect and examine another substance to provide a ... to prepare, collect, and examine specimens from the ...
Breaking Biology Technology:Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... coffee chain Stone Creek Coffee went about ... tool to enhance customer relationships: the blog. , ,According ... the blog can bring Stone Creek Coffee an ability ... releases or other traditional forms of communications. The company ...
... of a paper machine is something to hear. The spray of pulp ... the sound of industry. , ,But it's not the only sound. , ... forward, walk down the line a bit at Stora Enso's ... and listen to the hum as it carries 33-ton reels down the ...
... Catalyst International, Inc., has appointed Michael Eleftheriou ... than 30 years of experience in the information technology ... he last served as president of its Systems Integration ... Asia, India, Mexico and the Middle East. , ,Since ...
Cached Biology Technology:Business blogs increase customer interactions 2Business blogs increase customer interactions 3Business blogs increase customer interactions 4Business blogs increase customer interactions 5Cutting-edge technology keeps papermaker rolling 2Cutting-edge technology keeps papermaker rolling 3Cutting-edge technology keeps papermaker rolling 4
... an aqueous solution that contains a purified ... a PBS buffer (phosphate buffered saline), pH ... not contain a preservative. StabilCoat Immunoassay ... dried protein components in immunoassays and can ...
...
... DeCypher combines enterprise-scale sequence analysis software with the ... analyses. With DeCypher, you can perform searches like ... vs NCBI NT database in under 6 days ... genomic DNA Use HMM analysis to ...
... microplate readers combines reagent dispensing with fluorescence, ... easy-to-use platform for the complete range of ... and adaptability of the Infinite 200 series ... monochromator (M200) or filter (F200) system and ...
Biology Products: