Navigation Links
UT Southwestern researchers identify new targets for RNAs that regulate genes
Date:7/6/2008

DALLAS July 6, 2008 Tiny strands of genetic material called RNA a chemical cousin of DNA are emerging as major players in gene regulation, the process inside cells that drives all biology and that scientists seek to control in order to fight disease.

The idea that RNA (ribonucleic acid) is involved in activating and inhibiting genes is relatively new, and it has been unclear how RNA strands might regulate the process.

In a new study available online today and in a future issue of Nature Structural and Molecular Biology, RNA experts at UT Southwestern Medical Center found that, contrary to established theories, RNA can interact with a non-gene region of DNA called a promoter region, a sequence of DNA occurring spatially in front of an actual gene. This promoter must be activated before a gene can be turned on.

"Our findings about the underlying mechanisms of RNA-activated gene expression reveal a new and unexpected target for potential drug development," said Dr. David Corey, professor of pharmacology and biochemistry at UT Southwestern and one of the senior authors of the study.

Genes are segments of DNA housed in the nucleus of every cell, and they carry instructions for making proteins. Faulty or mutated genes lead to malfunctioning, missing or overabundant proteins, and any of those conditions can result in disease. Scientists seek to understand the mechanisms by which genes are activated, or expressed, and turned off in order to get a clearer picture of basic cell biology and also to develop medical therapies that affect gene expression.

In previous studies, Dr. Corey and Dr. Bethany Janowski, assistant professor of pharmacology at UT Southwestern and a senior author of the current study, have shown that tiny strands of RNA can be used to activate certain genes in cultured cancer cells. Using strands of RNA that they manufactured in the lab, the researchers showed that the strands regulate ge
'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UT Southwestern researchers identify hundreds of genes controlling female fertility
2. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
3. UT Southwestern secures $5 million NIH grant for lupus research
4. UT Southwestern scientist honored among best in Texas research
5. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
6. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
7. UT Southwesterns Mangelsdorf elected to National Academy of Sciences
8. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
9. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
10. Geology and biology meet in the history of US southwestern desert surface waters
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers identify new targets for RNAs that regulate genes
(Date:7/20/2015)... 2015  Acuity Market Intelligence,s latest research "The ... Commerce and Privacy" forecasts that between 2014 and ... be downloaded to smart mobile devices by 2.2 ... is projected to generate more than $67.9 billion ... forecast period.    "Biometrics is at ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
(Date:7/8/2015)... -- The consumer products industry for innovative tech ... such as wearables, smart wallets & other smart technology are ... continues to rapidly grow.  Biometrics & Wearable Device Companies in ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ... GPRO ) and Baidu Inc. (NASDAQ: BIDU ) ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... Louis, MO, October 26, 2010 In an insightful ... of the American Dietetic Association , Linda Van Horn, ... Dietary Guidelines Advisory Committee, and Professor and Associate Dean, ... features and noteworthy findings of the 2010 US Dietary ...
... Institute of Food and Agriculture (NIFA) awarded a $1.5 ... establish guidelines for increasing environmental, social, and economic sustainability ... Stewart of the U of I Department of Crop ... other ornamental crop production systems is waste generation due ...
... at the Institute of Vertebrate Paleontology and Paleoanthropology in ... in St. Louis, has discovered well-dated human fossils in ... emergence of modern humans in the eastern Old World. ... the online early edition of the Proceedings of ...
Cached Biology News:DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic 2DGAC report offers food and nutrition practitioners insights on helping combat obesity epidemic 3U of I receives $1.5 million to further sustainability in ornamental crop production 2U of I receives $1.5 million to further sustainability in ornamental crop production 3
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ... announces increased partnerships with VA and Military Medical ... Nerve Fiber Density (ENFD) and Sweat Gland Nerve ... fiber neuropathy ( https://therapath.com/skin ). ... Fiber Density (ENFD) on punch skin biopsy is ...
(Date:7/29/2015)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... announce that the final design specifications of its ... for industrial and regulatory testing will now be ... mark clearance to market the injector in ... (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  The RCI-02 ...
(Date:7/29/2015)... FRANCE (PRWEB) , ... July 29, 2015 , ... ... Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel, a nighttime-specific product that ... the amount of sugars that are able to enter fat cells, inhibiting the ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard ... Yet few people realize that a rich source of these cells is teeth—baby teeth ... teeth that need to be pulled to make room for braces. These potent ...
Breaking Biology Technology:Neuropathology services for VA and Military health systems 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2
... Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced ... antisense inhibition of novel targets that could offer new ... Cancer Research (AACR) meeting. Research conducted by Isis ... large non-coding RNA, sigma RNA also known as Malat-1, ...
... April 20 Shire plc (LSE: SHP,NASDAQ: SHPGY ), the global ... , , Results press release will be issued at: ... Investor conference call time: ... EDT, , Live conference call for investors: , ...
... NORWOOD, Mass. April 20 Advanced ... 2020-BIO Multi-Sample Osmometer as the first true automation-friendly ... 2020-BIO Multi-Sample Osmometer is specifically designed ... for osmolality testing in the biopharmaceutical laboratory," said ...
Cached Biology Technology:Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 2Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting 3Shire plc: First Quarter 2009 Results Date Notification - April 30, 2009 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 2Advanced Instruments Introduces 2020-BIO Multi-Sample Osmometer as First True Automation-Friendly Osmometer for the Biopharmaceutical Industry 3
... C 4 H 10 O ... 154.25 PRODUCT SPECIFICATIONS Form: White crystalline ... to 97% Identity: By IR Melting ... 38C Oxidized DTT: less than or ...
... Feature Extraction Software reads and ... to prepare microarray data for ... * one 2-year license ... NFP/Academic accounts , * ...
... imported for data analysis , Automatic grid, subgrid ... template assignment , ... Extensive background and signal options to optimize, ... results , ...
... Stain combo offers these benefits: ... Offers a safer and ... Eliminates risks to yourself, the environment and your ... bp to >30 kb. UltraPure Agarose is a standard ...
Biology Products: