Navigation Links
UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
Date:2/23/2009

DALLAS Feb. 24, 2009 Sleep experts know that the mental clarity lost because of a few sleepless nights can often be restored with a good night's rest. Now, UT Southwestern Medical Center researchers have identified a key molecular mechanism that regulates the brain's ability to mentally compensate for sleep deprivation.

Working with mice, they found that a molecule called an adenosine receptor is necessary for sleep-restricted animals to attain adequate levels of slow-wave activity in the brain once normal sleep resumes. It is this increase in slow-wave activity, or SWA, during rebound sleep that helps restore normal working memory and attention skills to the sleep-deprived, the scientists report in the Feb. 4 issue of the Journal of Neuroscience.

"Normal society pushes people to burn candles at both ends going to bed late, getting up early, and somehow performing mentally with lack of adequate sleep," said senior author Dr. Robert Greene, professor of psychiatry at UT Southwestern. "We need to have our adenosine receptors intact to do that."

Adenosine receptors on nerve cells, including brain cells, are akin to docking points for the molecule adenosine. Adenosine levels increase in the brain with each hour of waking activity, and "docking" of the molecule with its receptor is shown in this study to help promote the slow-wave activity of sleep. Scientists have known that recovery from sleep deprivation involves not only an increase in sleep time, or rebound sleep, but also an elevation in this slow-wave activity.

To investigate how adenosine receptors and SWA might be linked, Dr. Greene and his team engineered mice that lacked a receptor to pair up with adenosine.

Sleep-restricted mice were kept awake by being placed on a moving treadmill. Researchers then electronically monitored sleep and waking activity of both normal and genetically engineered mice, including monitoring electronically the brain waves
'/>"/>

Contact: LaKisha Ladson
lakisha.ladson@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. UT Southwestern scientist honored among best in Texas research
4. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
5. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
6. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
7. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
8. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
9. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
10. Limiting fructose may boost weight loss, UT Southwestern researcher reports
11. UT Southwestern researchers identify new targets for RNAs that regulate genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:3/31/2015)... 31, 2015   Guidepoint , a leading global ... Post-Surgical Pain Management TRACKER, part of the Guidepoint ... in the medical device and therapeutics markets. The Post-Surgical ... treatment volumes, market share, and adoption rates across three ... joint surgery. The Post-Surgical Pain Management TRACKER ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... Washington, DC Engineered nanoscale materials (ENMs), which ... use in food packaging, raise new safety evaluation ... report released today by the Project on Emerging ... The food-packaging industry, food companies and ...
... developed an effective technology for reducing contamination of dangerous ... Salmonella and E. coli O157:H7 on foods ranging from ... It is made from inexpensive and readily available ingredients ... and Drug Administration. The new technology, which ...
... Almost every June for 30 years, Terry McEneaney drove around ... three routes. Park ornithologist at the time, he would ... Then he,d drive another half mile, repeat the process and ... for the North American Breeding Bird Survey. Trying to finish ...
Cached Biology News:Use of nanomaterials in food packaging poses regulatory challenges 2New UGA invention effectively kills foodborne pathogens in minutes 2Bird watchers, space technology come together in Montana State University study 2Bird watchers, space technology come together in Montana State University study 3
(Date:5/5/2015)... , May 05, 2015 Research and Markets ... addition of the "Clinical Laboratory, Molecular Diagnostics ... 2015 to 2019 - Europe Version" report ... especially in the area of molecular diagnostics and ... and evolving world market that is moving out ...
(Date:5/5/2015)... May 05, 2015 Exotic ... distributor, announces the launch of http://www.cng.exoticautomation.com , ... with a convenient way to purchase genuine OEM ... . , The new website provides owners ... with direct access to high performance products for ...
(Date:5/5/2015)... MA (PRWEB) May 05, 2015 The ... ), a Massachusetts-based non-profit operating in the public interest, ... affiliate of the Hearst Communications Company, have formed a ... for public outreach and education across the healthcare and ... for the voice of patients and the public to ...
(Date:5/4/2015)...   St. Jude Children,s Research Hospital ... for finding genetic alterations that play an important ... identify with whole-genome sequencing. The findings appear today ... The tool is an algorithm called ... Tree in Next Generation Sequencing. ...
Breaking Biology Technology:European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2Exotic Automation & Supply Launches Ecommerce Website 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 2ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 3ACRES and San Antonio Express-News Launch Blog on Accountability in Clinical Research 4Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4
... Nov. 27 Corium International, Inc.,a privately-held transdermal ... Gardner, M.D. and Daniel G. Welch to the ... Essex Woodlands Health,Ventures, is a Professor of Medicine ... of cell biology and pharmacology. In addition to,her ...
... Therapeutics,(Nasdaq: FOLD ) today announced that it will host ... 7:00 PM at the Four Seasons Hotel in New,York City. ... the,Phase 2 clinical trials performed for Amigal(TM) (migalastat hydrochloride),for Fabry ... other,research and development programs at the company., A live ...
... an FDA 510(k) (Pre-Market Notification), Pathway for AppyScore(TM), the First Blood-based ... ... ROCK, Colo., Nov. 27 AspenBio Pharma,Inc. (Nasdaq: APPY ) ... diagnostics for animals and humans, has,received an official response from the ...
Cached Biology Technology:Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 2Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board 3Amicus Therapeutics to Host R&D Day 2Amicus Therapeutics to Host R&D Day 3AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 2AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 3AspenBio Pharma Pursues FDA 510(k) Application Pathway for Appendicitis Blood Test 4
... Services include: ,ISH Protocol ... Conditions Analyses ,RNA and DNA ... Cells and Tissues ,Double Labeling ... Cells and Tissues ,RNA and ...
Request Info...
IC50: 190 pg/ml · Limit of detection: 60 pg/ml...
Request Info...
Biology Products: