Navigation Links
UT Southwestern researchers identify key molecular step to fighting off viruses
Date:4/21/2010

DALLAS April 21, 2010 UT Southwestern Medical Center researchers have determined how a protein that normally latches onto molecules inside cells and marks them for destruction also gives life to the body's immune response against viruses.

The researchers discovered that a certain form of the "death" protein ubiquitin interacts with another protein, called RIG-I, but does not mark it for destruction. Instead, this form of ubiquitin binds to and activates RIG-I, which is known to trigger the body's immune system when a virus invades a cell.

Dr. Zhijian "James" Chen, professor of molecular biology at UT Southwestern, is senior author of the study, which is available online and in the journal Cell.

Dr. Chen and his colleagues reconstituted key elements of the human innate immune system in laboratory test tubes and found ubiquitin forms a unique chain-like structure that associates with RIG-I before RIG-I can get to work fighting viruses. The innate immune system is the body's first generic response against invading pathogens.

"Activation of RIG-I is the first line of our immune defenses against viral infections," said Dr. Chen, an investigator for the Howard Hughes Medical Institute at UT Southwestern. "Understanding how it comes to life is a key step in developing new approaches to antiviral therapies. Having this test-tube system could help us identify substances that enhance the body's antiviral immunity."

Dr. Chen said his team's experiments mark the first time innate immunity has been recapitulated in a test tube. The findings provide one of the missing pieces in the complex puzzle of how the body fights off infection, he added.

Dr. Chen is now focusing on how activated RIG-I interacts with another protein called MAVS, also essential for immune response.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
2. New brain nerve cells key to stress resilience, UT Southwestern researchers find
3. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
4. UT Southwestern researchers find clues to TB drug resistance
5. American pika are thriving in the Sierra Nevada and southwestern Great Basin
6. Insect wranglers invade the garden at Southwestern science EXPO
7. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
8. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
9. The impact of the diffusion of maize to the Southwestern United States
10. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
11. UT Southwestern receives $42 million in Recovery Act stimulus funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... Palo Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... is set to take place on 7th and 8th June 2018 in San Francisco, ... and policy influencers as well as several distinguished CEOs, board directors and government officials ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. 11, ... Research, London (ICR) and University of ... SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma (MM), ... nine . The University of Leeds ... funded by Myeloma UK, and ICR will perform the testing ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
Breaking Biology Technology: