Navigation Links
UT Southwestern researchers identify key molecular step to fighting off viruses
Date:4/21/2010

DALLAS April 21, 2010 UT Southwestern Medical Center researchers have determined how a protein that normally latches onto molecules inside cells and marks them for destruction also gives life to the body's immune response against viruses.

The researchers discovered that a certain form of the "death" protein ubiquitin interacts with another protein, called RIG-I, but does not mark it for destruction. Instead, this form of ubiquitin binds to and activates RIG-I, which is known to trigger the body's immune system when a virus invades a cell.

Dr. Zhijian "James" Chen, professor of molecular biology at UT Southwestern, is senior author of the study, which is available online and in the journal Cell.

Dr. Chen and his colleagues reconstituted key elements of the human innate immune system in laboratory test tubes and found ubiquitin forms a unique chain-like structure that associates with RIG-I before RIG-I can get to work fighting viruses. The innate immune system is the body's first generic response against invading pathogens.

"Activation of RIG-I is the first line of our immune defenses against viral infections," said Dr. Chen, an investigator for the Howard Hughes Medical Institute at UT Southwestern. "Understanding how it comes to life is a key step in developing new approaches to antiviral therapies. Having this test-tube system could help us identify substances that enhance the body's antiviral immunity."

Dr. Chen said his team's experiments mark the first time innate immunity has been recapitulated in a test tube. The findings provide one of the missing pieces in the complex puzzle of how the body fights off infection, he added.

Dr. Chen is now focusing on how activated RIG-I interacts with another protein called MAVS, also essential for immune response.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
2. New brain nerve cells key to stress resilience, UT Southwestern researchers find
3. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
4. UT Southwestern researchers find clues to TB drug resistance
5. American pika are thriving in the Sierra Nevada and southwestern Great Basin
6. Insect wranglers invade the garden at Southwestern science EXPO
7. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
8. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
9. The impact of the diffusion of maize to the Southwestern United States
10. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
11. UT Southwestern receives $42 million in Recovery Act stimulus funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events ... announced today. The bold new look is part of a transformation to increase ... a significant growth period. , It will also expand its service offering from its ...
Breaking Biology Technology: