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UT Southwestern researchers identify hundreds of genes controlling female fertility
Date:9/21/2007

follicle growth were all turned on at the same time, making it easier to detect these genes.

The researchers employed a method known as expression profiling to identify the active genes. They found 348 genes that were active in ovaries in the mice lacking Foxo3, but not in other tissues, indicating that they could function specifically in follicle growth.

Some of the genes the researchers found were already known to be involved in infertility, which helped validate the experimental method. Most, however, were previously unknown, Dr. Castrillon said.

The researchers also randomly selected a small number of genes from the 348 and looked for them in human ovaries. Those specific genes proved to be active in early development of the human ovary.

Future work will focus on finding out how these genes communicate with each other to control follicle development, and study their contribution to female infertility, Dr. Castrillon said.


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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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