Navigation Links
UT Southwestern researchers identify hundreds of genes controlling female fertility
Date:9/21/2007

DALLAS Sept. 21, 2007 Researchers at UT Southwestern Medical Center have found nearly 350 genes related to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility.

This study gives us a way to begin to understand the causes of female infertility, said Dr. Diego Castrillon, assistant professor of pathology and senior author of a study appearing in the September issue of the journal Genetics. It gives us a much more complete list of candidate genes to explore. Before, we didnt even know where to look.

The study was done in mice, but at the molecular level, ovarian biology is very similar in mice and humans, Dr. Castrillon said.

These discoveries might lead the way to eventually allowing clinicians to test whether an infertile woman has problems with a specific gene, allowing for improved diagnostic tests and tailored therapy in the future, said Dr. Castrillon, a specialist in the diagnosis of infertility and other diseases of women.

About 13 percent of women suffer from infertility, with the most common cause being dysfunction of the ovary. Researchers suspected genetic links in many cases, Dr. Castrillon said.

In mammals, the ovaries go through a developmental stage after birth in which egg cells become nestled in dormant nests called primordial follicles. Later in development, the follicles become activated by a process that researchers dont fully understand, and at puberty, egg cells begin being released for fertilization. The researchers focused on a gene called Foxo3, which controls follicle activation. Normally, follicles are activated on a staggered schedule, so an ovary contains follicles at many different stages of development.

In female mice genetically engineered to lack Foxo3, the follicles are normal at birth, but later become activated all at the same time. This coordinated maturation meant that the genes controlling
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers discover master switch in cell death
2. UT Southwestern researchers develop screening test for cells that activate immune system
3. UT Southwestern researchers unravel control of growing blood vessels
4. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
5. UT Southwestern researchers find gene mutation that leads to broken hearts
6. Napoleons mysterious death unmasked, UT Southwestern researcher says
7. Researchers discover way to make cells in the eye sensitive to light
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Researchers Uncover Key Step In Manufacture of Memory Protein
10. NYU researchers simulate molecular biological clock
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
(Date:4/10/2015)... 10, 2015 Research and Markets ... "Security Competitive Profiles - NEC" report to ... NEC will continue to supply a range of ... with a company focus on the development of a ... Winning opportunities in the Asia-Pacific ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... , LAS VEGAS , April 27 In its third ... open to a more inclusive pool of contestants and takes place three times ... Championship) invites any company with tea inventory in North America to ... harvests of hot tea, as well as iced tea. , ...
... April 27 From international jetsetter to model to entrepreneur, ... resume as she unveils her debut collection for QVC. The Slovenian beauty is scheduled ... PM (ET) to debut the Melania™ Timepieces & Fashion Jewelry line ... , , ...
... with a volume equivalent to 40 Amazon Rivers has been ... in the Indian Ocean sector of the Southern Ocean, 4200 ... Nature Geoscience , the researchers described the current more ... important pathway in a global network of ocean currents that ...
Cached Biology News:World Tea Expo Throws Open Door to Tea Championship 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 3Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 4Massive Southern Ocean current discovered 2
(Date:4/30/2015)... 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" or ... contract R&D services provider, today announced that its board ... dated April 29, 2015, from a consortium (the "Consortium") ... founder, chairman and chief executive officer of the Company, ... a transaction (the "Transaction") involving the acquisition of all ...
(Date:4/30/2015)... SureClinical, a leader in cloud-based health science ... SureClinical’s executive team as Chief Financial Officer. ... with over 25 years in leadership roles ranging from ... Morris joins SureClinical from Marrone Bio Innovations (MBI), a ... MBI from its founding in 2006 until 2011, when ...
(Date:4/29/2015)... 30, 2015 According to a ... by Product (Portable & Non-Portable), Component (Accelerometer, Proximity ... Chemical, Metal & Mining, & Others), & Geography ... is expected to reach $1,453.76 Million by 2020, ... market data tables and 92 figures spread through ...
(Date:4/29/2015)... 2015   Doximity , the leading online medical ... as members, announced a new, instant method for physicians ... With one click, all US physicians can quickly submit ... for an open job opportunity, and a recruiter will ... seven percent of physicians are open to new jobs, ...
Breaking Biology Technology:WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Julie I. Morris Joins SureClinical as Chief Financial Officer 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2
... Wash.The world,s biggest Roman candle has got nothing on ... in the Earth or on a giant planet, Washington ... capable of storing vast amounts of energy. "If you ... of energy storage outside of nuclear energy," says Choong-Shik ...
... engineering school in Grenoble, France, and Virginia Tech is ... The students, work will help gene synthesis companies and ... DNA as harmful agents for bioterrorism. Synthetic biology ... production, agriculture, and other areas. For a few thousand ...
... Nanoscience has garnered billions of dollars of funding and ... Revolution. But, for such a richly anticipated field, ... us from odor-eating socks to cosmetics and medications ... with visions of nanotechnology as cornucopia or Armageddon. ...
Cached Biology Technology:iGEM team helps prevent rogue use of synthetic biology 2New resource examines questions about the role of nanoscience 2
... Rabbit polyclonal to BMP2 ... factor beta (TGFB) superfamily. Bone morphogenic ... a candidate gene for the autosomal ... progressiva. Immunogen: Synthetic ...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
...
... manual heat sealer ideal for low to medium ... seal a wide range of plates of differing ... element of the sealer is pre-set for optimal ... when used in conjunction with ABgenes sealing foil ...
Biology Products: