Navigation Links
UT Southwestern researchers identify hundreds of genes controlling female fertility
Date:9/21/2007

DALLAS Sept. 21, 2007 Researchers at UT Southwestern Medical Center have found nearly 350 genes related to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility.

This study gives us a way to begin to understand the causes of female infertility, said Dr. Diego Castrillon, assistant professor of pathology and senior author of a study appearing in the September issue of the journal Genetics. It gives us a much more complete list of candidate genes to explore. Before, we didnt even know where to look.

The study was done in mice, but at the molecular level, ovarian biology is very similar in mice and humans, Dr. Castrillon said.

These discoveries might lead the way to eventually allowing clinicians to test whether an infertile woman has problems with a specific gene, allowing for improved diagnostic tests and tailored therapy in the future, said Dr. Castrillon, a specialist in the diagnosis of infertility and other diseases of women.

About 13 percent of women suffer from infertility, with the most common cause being dysfunction of the ovary. Researchers suspected genetic links in many cases, Dr. Castrillon said.

In mammals, the ovaries go through a developmental stage after birth in which egg cells become nestled in dormant nests called primordial follicles. Later in development, the follicles become activated by a process that researchers dont fully understand, and at puberty, egg cells begin being released for fertilization. The researchers focused on a gene called Foxo3, which controls follicle activation. Normally, follicles are activated on a staggered schedule, so an ovary contains follicles at many different stages of development.

In female mice genetically engineered to lack Foxo3, the follicles are normal at birth, but later become activated all at the same time. This coordinated maturation meant that the genes controlling follicle growth were all turned on at the same time, making it easier to detect these genes.

The researchers employed a method known as expression profiling to identify the active genes. They found 348 genes that were active in ovaries in the mice lacking Foxo3, but not in other tissues, indicating that they could function specifically in follicle growth.

Some of the genes the researchers found were already known to be involved in infertility, which helped validate the experimental method. Most, however, were previously unknown, Dr. Castrillon said.

The researchers also randomly selected a small number of genes from the 348 and looked for them in human ovaries. Those specific genes proved to be active in early development of the human ovary.

Future work will focus on finding out how these genes communicate with each other to control follicle development, and study their contribution to female infertility, Dr. Castrillon said.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related biology news :

1. UT Southwestern researchers discover master switch in cell death
2. UT Southwestern researchers develop screening test for cells that activate immune system
3. UT Southwestern researchers unravel control of growing blood vessels
4. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
5. UT Southwestern researchers find gene mutation that leads to broken hearts
6. Napoleons mysterious death unmasked, UT Southwestern researcher says
7. Researchers discover way to make cells in the eye sensitive to light
8. Researchers find how protein allows insects to detect and respond to pheromones
9. Researchers Uncover Key Step In Manufacture of Memory Protein
10. NYU researchers simulate molecular biological clock
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... , ... Parallel 6 , the leading software as a service (SaaS) ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication between ... Using the CONSULT module, patients and physicians can schedule a face to face virtual ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is pleased to announce the launch of their brand, UP4™ Probiotics, into Target ... over 35 years, is proud to add Target to its list of well-respected ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: