Navigation Links
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
Date:12/19/2008

normally responsible for producing the telomerase enzyme, which elongates the lengths of DNA at the ends of chromosomes, called telomeres. In normal cells, telomeres shorten each time the cell divides. When they reach a certain length, the cell stops dividing. In most cancerous cells, telomeres don't shorten during cell division, allowing the cells to remain effectively immortal. Mutations in either of these two genes can be found in almost 15 percent of those with familial IPF. Up to 40 percent have short telomere lengths and evidence of telomerase dysfunction.

"But we were still left with a big question mark," Dr. Garcia said. "What about the rest of the families that have normal telomere lengths? What was causing their lung disease?"

In the current study, Dr. Garcia and her team focused on families that did not have TERC or TERT mutations. By using a genomic linkage approach a technique that scans the entire human genome for regions of DNA that are shared in common by all the individuals with the disease they were led to mutations in a gene called SFTPA2. The protein produced by this gene, surfactant protein A2, is found in the fluid of the lungs and helps protect the organ from invading pathogens.

Many of the individuals in this family who carried this mutation had not only IPF but also lung cancer, especially adenocarcinoma, with features of bronchioloalveolar cell carcinoma. It is known that people with IPF have a higher risk for developing lung cancer, and Dr. Garcia suspects that mutations in the SFTPA2 gene are associated with both IPF and lung cancer. Another family harboring a different mutation in the SFTPA2 gene also had members that exhibited IPF and lung cancer.

Dr. Garcia and her team are now working on molecular studies in cells to determine why these gene mutations put patients at risk for either of these diseases. They are also working to develop an animal model in order to determine the specific effects of
'/>"/>

Contact: Connie Piloto
connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UT Southwestern researchers identify hundreds of genes controlling female fertility
2. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
3. UT Southwestern secures $5 million NIH grant for lupus research
4. UT Southwestern scientist honored among best in Texas research
5. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
6. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
7. UT Southwesterns Mangelsdorf elected to National Academy of Sciences
8. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
9. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
10. Geology and biology meet in the history of US southwestern desert surface waters
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
(Date:7/9/2014)... Indiana state parks have helped restore the health of ... populations of white-tailed deer, a Purdue study shows. , ... of forest ecology, found that a 17-year-long Indiana Department ... parks has successfully spurred the regrowth of native tree ... , Jenkins said that while hunting may be ...
(Date:7/9/2014)... to species, selection for traits that are attractive to ... enhances opportunities to mate, the tail of male peacocks ... of California, Riverside have now found that sexual selection ... are linked. Describing the life histories of more than ... researchers found that species with placentas tend to have ...
(Date:7/9/2014)... New Rochelle, NY, July 9, 2014Biofuels derived from the ... alternative to fossil fuels. To achieve this goal, optimization ... as in open pond systems, is needed. Sapphire Energy ... contamination of open pond algae cultivation systems, described in ... Ann Liebert, Inc., publishers. The article is available on ...
Breaking Biology News(10 mins):Hunting gives deer-damaged forests in state parks a shot at recovery 2Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Controlling contamination in open algae ponds for biofuels 2
... backdrop of the Montreal Summit on global climate being ... monsoons, by a University of California, Santa Barbara scientist ... the journal Geology, underlines concern about the effects of ... vegetation have an important effect on African monsoon systems, ...
... south and central America such as the Amazon rainforest are ... around 65 species in Britain. UCL scientists have ruled out ... climate change, in a paper published on 7th December by ... , Instead, scientists believe that biology played a far ...
... uncovered new details about how estrogen can activate natural pathways ... raise the possibility that estrogen therapy may overcome resistance to ... December 7 issue of the Journal of the ... treatments such as chemotherapy or hormonal therapy fail to cause ...
Cached Biology News:Tropical Atlantic cooling and African deforestation correlate to drought, report scientists 2Why the Amazon rainforest is so rich in species 2Why the Amazon rainforest is so rich in species 3 Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer 2
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... Berkeley -- Engineers at the University of California, Berkeley, ... that could revitalize optical lithography, a patterning technique that ... lenses that focus light through the excitation of electrons ... a "flying head" that resembles the stylus on the ...
... 28, SAN DIEGO, Oct. 22 Neurocrine Biosciences,Inc. ... will report its third,quarter 2008 financial results after the ... host a live conference call and webcast,to discuss its ... 28, 2008 at 5:00 p.m. Eastern Time (2:00 p.m. ...
... Billion, Third Quarter 2008 GAAP Earnings Per Share were $1.09, an Increase ... GAAP Earnings Per Share of $0.18, Full Year Revenue Guidance Raised from ... ... - $4.45 to $4.45 - $4.55, THOUSAND OAKS, Calif., Oct. 22 ...
Cached Biology Technology:Denser, more powerful computer chips possible with plasmonic lenses that 'fly' 2Denser, more powerful computer chips possible with plasmonic lenses that 'fly' 3Denser, more powerful computer chips possible with plasmonic lenses that 'fly' 4Neurocrine Biosciences Announces Conference Call and Webcast to Present Third Quarter 2008 Financial Results 2Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 2Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 3Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 4Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 5Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 6Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 7Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 8Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 9Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 10Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 11Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 12Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 13Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 14Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 15Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 16Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 17Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 18Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 19Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 20Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 21Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 22Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 23Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23 24
... for ambient HPLC. Contains connections and ... two external devices such as RI ... analog output from the 90 detector ... Includes an input for synchronization with ...
... The FDSS6000 System is an ... assays, assay development and high throughput ... and luminescence modalities., The Hamamatsu light ... highlight our companys decades-long experience in ...
... StdSens reagents and supplies, for 10 ... sufficient to perform standard-sensitivity RNA analysis ... the Experion automated electrophoresis system. Supplied ... microliters RNA StdSens stain, 20 microliters ...
... 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide White solid. ... GAS. A cell-permeable sulfanamido-benzbromarone compound that ... non-competitive allosteric inhibitor of PTP1B (IC ... 8 μM for PTP1B 403 ...
Biology Products: