Navigation Links
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

DALLAS Dec. 19, 2008 Researchers at UT Southwestern Medical Center have determined that a mutation in a gene known for its role in defending the lungs against invading pathogens is responsible for some inherited cases of a lethal lung disease affecting older adults. The same mutation may also be associated with lung cancer, the researchers said.

This is the third gene that UT Southwestern scientists have linked with idiopathic pulmonary fibrosis, or IPF. The study appears online this week and in the January issue of American Journal of Human Genetics.

In the U.S., about 200,000 patients have IPF, and about 40,000 patients die from the disease each year, according to the Pulmonary Fibrosis Foundation. The disease typically strikes people in their 50s and older, causing severe scarring of the lungs. Death usually occurs within three years of diagnosis.

"We don't have any medicines to treat this disease," said Dr. Christine Garcia, assistant professor in the Eugene McDermott Center for Human Growth and Development and of internal medicine at UT Southwestern and the study's senior author. "If a patient is younger than 65, lung transplantation is an option, but most people who develop IPF are older than that."

The ultimate goal, Dr. Garcia said, is to find or develop a medication that can stem the progression of this pulmonary condition.

About one in 50 IPF patients have an inherited form of the disease. It is this familial form of the disease that Dr. Garcia her colleagues are focused on.

"We've been trying to identify the genes and genetic variants that underlie this disease," Dr. Garcia said. "Now, we know there are multiple genes involved."

In 2007, Dr. Garcia and her research team studied two large families in which multiple individuals were affected with IPF to search for a gene causing the disease. This led to the discovery of mutations in genes called TERT and TERC. These two genes are

Contact: Connie Piloto
UT Southwestern Medical Center

Page: 1 2 3

Related biology news :

1. UT Southwestern researchers identify hundreds of genes controlling female fertility
2. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
3. UT Southwestern secures $5 million NIH grant for lupus research
4. UT Southwestern scientist honored among best in Texas research
5. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
6. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
7. UT Southwesterns Mangelsdorf elected to National Academy of Sciences
8. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
9. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
10. Geology and biology meet in the history of US southwestern desert surface waters
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
Related Image:
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
(Date:6/24/2015)... This report provides market analysis of the ... It contains an analysis of the drivers, challenges, and ... from the short, medium, and long term perspective landscapes. ... and technology trends that currently, prevail in the market. ... to efficiently manage the increasing marine traffic and increasing ...
(Date:6/24/2015)... , June 22, 2015 ... the addition of the "Huawei Ascend Mate ... report to their offering. Huawei,s technological ... the opposite direction than Apple,s and Samsung,s one. ... sensor developed by Fingerprint Cards, a main actor ...
(Date:6/23/2015)... , June 23, 2015   MedNet Solutions ... supports the entire spectrum of clinical research, is ... ™ , the company,s intuitive, flexible and ... a Silver 2015 Stevie® Award by the ... & Services Website category.  The American Business Awards ...
Breaking Biology News(10 mins):Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2
... scientists survey five New York flu seasons , On the ... for Genomic Research (TIGR) have captured influenza evolution in action. ... , the researchers report the first large-scale project to sequence ... the rapidly evolving flu virus in a human population--and a ...
... Using functional magnetic resonance imaging, or fMRI, researchers at the ... the act of recalling a memory is a bit like ... 23 edition of the journal Science, demonstrates that the same ... are activated when a person attempts to recall that event ...
... medical research team has identified a new gene linked ... a previously discovered gene known to increase the risk ... Edinburgh and Glasgow, together with scientists from the pharmaceutical ... of the second gene, phosphodiesterase 4B (PDE4B) in the ...
Cached Biology News:First big influenza genome study reveals flu evolution 2First big influenza genome study reveals flu evolution 3First big influenza genome study reveals flu evolution 4Researchers know what you were about to say; fMRI used to detect memory storage and retrieval 2Scientists move forward understanding of schizophrenia 2
(Date:7/24/2015)... 2015 Ryan & Maniskas, LLP that ... District Court for the Northern District of California ... purchased the common stock of Avalanche Biotechnologies, Inc. ("Avalanche" or ... and June 15, 2015, inclusive (the "Class Period"). ... the Court for appointment as a lead plaintiff of the ...
(Date:7/24/2015)... Agritech Limited (NASDAQ GS: SEED) ("Origin", or the "Company"), a ... , today announced that the Company will report results for ... before the market opens on Wednesday, August 5th, 2015. ... 2015, at 9:00 a.m. ET / 9:00 p.m. ... in the call, please dial the following numbers approximately 5 ...
(Date:7/23/2015)... ... July 23, 2015 , ... The health and wellness of brain ... management of a brain tumor diagnosis. The American Brain Tumor Association presents interactive sessions ... Patient and Family Conference, July 24-25 in Chicago. , “We have understood for ...
(Date:7/23/2015)... ... 2015 , ... The Pittcon 2016 Program Committee is extremely pleased to announce ... Professor, by courtesy, of Applied Physics at Stanford University, will present the Wallace ... Nanoscopy in Cells and Beyond” , Dr. Moerner’s lecture will focus on his ...
Breaking Biology Technology:Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 3Origin Agritech Limited to Announce Third Quarter Fiscal 2015 Unaudited Financial Results on August 5th, 2015 2Origin Agritech Limited to Announce Third Quarter Fiscal 2015 Unaudited Financial Results on August 5th, 2015 3Reframing the Caregiver and Patient Mindset: Coping with the ‘New Normal’ 2Reframing the Caregiver and Patient Mindset: Coping with the ‘New Normal’ 3The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 2The 2014 Nobel Prize in Chemistry Recipient W. E. Moerner, to Deliver Wallace H. Coulter Lecture at Pittcon 2016 3
... Appear in Sept. 9 Issue of the Journal Nature ... hits with,devastating effects in people with normal cholesterol levels, ... risk factors. A new,research discovery may help explain why ... Researchers at Cleveland Clinic,s Lerner Research Institute have,discovered ...
... CLAREMONT, Calif., Sept. 10 /Xinhua-PRNewswire-FirstCall/,-- Kiwa Bio-Tech Products ... China Green Food Association of the Agriculture Ministry,("CGFA") ... Food CGFA,Recommend Brands." The vice president of ... over 13 million hm2 (hectares) of planting area ...
... UBC ClinResearch to Expand Global Reach in Pioneering ... BioSource Corporation,(UBC) today announced the acquisition of an ... technology solutions and services for,flexible, or adaptive, clinical ... employees, ClinResearch has designed and implemented 80,adaptive programs ...
Cached Biology Technology:Cleveland Clinic-Led Research Uncovers New Mechanism That Heightens Risk of Heart Disease 2Cleveland Clinic-Led Research Uncovers New Mechanism That Heightens Risk of Heart Disease 3Kiwa Bio-Tech Named Recommended Brand by the China Green Food Association 2United BioSource Acquires Interest in Leading Adaptive Design Technology Service Provider 2
For the differentiation of mouse embryonic stem cells tooligodendrocytes....
Preadipocyte factor-1 [Pref-1, DLK-1], C-terminal...
IC50: 35 ng/ml · Limit of detection: 8 ng/ml...
, Glycerol 30%...
Biology Products: