Navigation Links
UT Southwestern researchers find protein that might be key to cutting cancer cells' blood supply
Date:5/11/2011

DALLAS May 12, 2011 UT Southwestern Medical Center researchers have discovered a protein that guides blood vessel development and eventually might lead to a treatment to keep cancer cells from spreading.

The researchers showed in mice that the Ras interacting protein 1 (Rasip1) is so specific and central to so many cellular processes that without it new blood vessels simply cannot form, said Dr. Ondine Cleaver, assistant professor of molecular biology at UT Southwestern and senior author of the study in the April issue of Developmental Cell.

"What we've found is really the first factor that is important in all blood vessels for inner channel formation and tubulogenesis, i.e., the transformation of something that looks like a rope into something that looks like a garden hose," Dr. Cleaver said.

Cancer cells depend on the body's creation of new blood vessels to deliver the nutrients that fuel cancer's rapid growth. Cancerous tumors also use the circulatory system as a superhighway through which they send malignant cells to colonize other parts of the body. A Rasip1-blocking drug conceivably could fight cancer on two fronts: by starving the cancerous cells and by cutting off their transport routes, Dr. Cleaver said.

During fetal development the body creates many tube-shaped organs such as the intestines of the digestive system and the vessels of the cardiovascular system. The mechanisms by which blood vessel progenitor cells transform into tubes that can carry blood are only beginning to be understood, she said.

Scientists have found many regulatory molecules important in different tissues and even in other aspects of blood vessel formation or maintenance, but all of them are active in multiple body tissues. Rasip1 is the first blood vessel-specific regulator of molecular switches called GTPases, she said. The protein appears to be active only in the endothelium, the layer of cells that line the blood vessels,
'/>"/>

Contact: Deborah Wormser
deborah.wormser@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern research reveals how cancer-driving enzyme works
2. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
3. Team of scientists predicts continued death of forests in southwestern US due to climate change
4. UT Southwestern researchers uncover culprits in life-threatening clotting disorder
5. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
6. UT Southwestern researchers find key step in bodys ability to make red blood cells
7. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
8. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
9. UT Southwestern researchers identify key molecular step to fighting off viruses
10. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
11. New brain nerve cells key to stress resilience, UT Southwestern researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/8/2015)... 8, 2015 Summary Pancreatic cancer is ... most fatal, with a mortality rate of 10.9 deaths ... pancreatic cancer patients has highlighted a significant need for ... being met by the current market. A highly ... with varying molecule types and mechanisms of action, which ...
(Date:7/8/2015)... CORAL SPRINGS, Florida , July 8, 2015 ... is constantly evolving as this summer,s must have products such ... high in demand as popularity for biometrics based devices continues ... today are NXT-ID, Inc. (NASDAQ: NXTD ), Google Inc. ... Fitbit Inc. (NYSE: FIT ), GoPro, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6
... is available in Spanish . , Spoilage ... during fermentation may actually help clean up dyes in ... Agriculture (USDA) study. Some species of ... a yellow food-coloring agent used in the manufacture of ...
... New Rochelle, NY, September 17, 2010September is National Childhood ... obesity among children and adolescents in the United States. ... for effective weight management and should draw from the ... policy initiatives, all of which are presented and debated ...
... NY) As government support for personalized medicine grows, ... controversies. Direct-to-consumer genetic tests, privacy, targeted cancer therapies, and ... of the Hastings center Report ... the use of genetic information to individualize treatment, ...
Cached Biology News:Pickle spoilage bacteria may help environment 2With growing US support for personalized medicine, a look at ethical dilemmas 2
(Date:7/30/2015)... ... July 30, 2015 , ... ... field clinical study of its canine osteoarthritis stem cell product, currently under development ... City, KS) and will be marketed in the US by Aratana. This product, ...
(Date:7/30/2015)...  With over 60,000 customers across the globe, ISN improves the efficiency and effectiveness ... more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In ... Headquartered in Dallas, TX , ISN has additional ...
(Date:7/30/2015)... 30, 2015  Discovery Laboratories, Inc. (Nasdaq: ... the second $1.0M tranche under a previously awarded ... valued at up to $3.0 million to support ... as a potential medical countermeasure to mitigate acute ... awarded an initial $1.0 million under this grant ...
(Date:7/29/2015)... 30, 2015 Sanofi, a ... the second quarter of 2015. CEO Olivier ... its performance in different businesses. Watch ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered in the ... - Performance drivers - Diabetes ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... , ROCKVILLE, Md., July 21 Novavax, Inc. ... John J. Trizzino as Senior Vice President, International and Government ... report directly to Dr. Rahul Singhvi, Novavax,s President and Chief ... company,s international alliances with pharmaceutical companies and all governmental agencies, ...
... , LANSING, Mich., July 21 Neogen ... in revenues for its 2009 fiscal year, which ended May 31, ... , , Neogen,s revenues for FY ... year. The 2009 results reflect changes in currency exchange rates that ...
... , ST. JOSEPH, Mich.,. July ... company, announced today that they have recently donated 41 ... and Cytokine Research (www.isicr.org). These maps are constructed from ... Each map describes multi-step signaling covering the full spectrum ...
Cached Biology Technology:Novavax Announces Appointment of John J. Trizzino as Senior Vice President, International and Government Alliances 2Neogen Reports 16% Increase in Revenues 2Neogen Reports 16% Increase in Revenues 3Neogen Reports 16% Increase in Revenues 4Neogen Reports 16% Increase in Revenues 5Neogen Reports 16% Increase in Revenues 6GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR 2
Human Ig Lambda-chain, clone ICO-16, Monoclonal Antibody...
Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2). [Source:Uniprot/SWISSPROT;Acc:P19878] Antigen: Recombinant Protein E...
Rad51, N-terminal...
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: