Navigation Links
UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
Date:5/23/2011

already starting to have problems. So we know genetic and environmental factors contribute to this," Dr. Word said.

Using mice, researchers tested how fibulin-5, a protein that is essential for elastic fiber assembly, regulated the activity of matrix metalloprotease-9 (MMP-9), a group of enzymes that break down the matrix of collagen and elastic fibers, leading to a loss of the structural support of the vaginal wall.

Researchers used a fibulin-5 deficient rodent model and a new domain-specific mutant of fibulin-5 to demonstrate that fibulin-5-mediated elastogenesis (development of elastic fibers) is essential to support the pelvic organs. They also showed that prolapse of the vaginal wall requires an increase in MMP-9, but that fibulin-5 inhibits activation of this protease in a tissue-specific manner.

"Matrix assembly of the vaginal wall is a very complicated process," said Dr. Hiromi Yanagisawa, assistant professor of molecular biology and the study's other co-senior author. "We need to decode what is necessary in this process, but degrading enzymes are the main therapeutic focus."

Dr. Word said, "The bottom line is the whole matrix is maintained by a balance between synthesis and degradation. Our goal is to optimize pelvic organ support and target these proteases that degrade the matrix."


'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
2. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
3. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
6. UT Southwestern scientist honored among best in Texas research
7. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
8. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
9. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
10. Two UT Southwestern researchers awarded Sloan fellowships
11. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from Ume University, Sweden, have explored two different ... reaction sequence leading to the formation of oxygen ... published in the scientific journal Nature Communications ... present day synthetic catalysts for water oxidation, which ... for the direct storage of solar energy in ...
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... electronic skin, or e-skin, and electronic eye implants or ... Researchers with Berkeley Lab and the University of California ... of carbon nanotubes and silver nanoparticles similar to the ... e-whiskers respond to pressure as slight as a single ...
... of men,s bones - but only if they marry when they,re ... In a study published online in the peer-reviewed journal Osteoporosis ... were younger than 25 had lower bone strength than men who ... In addition, men in stable marriages or ...
... climate. Take, for example, the Mayans, who, throughout the ... their major ceremonial centers after a series of multi-year droughts, ... forests. Much later, in the late 20th century, frequent droughts ... migrate from the dry north to the wetter south where ...
Cached Biology News:E-whiskers 2Guys: Get married for the sake of your bones, but wait until you're 25 2Guys: Get married for the sake of your bones, but wait until you're 25 3Princeton model anticipates ecological impacts of human responses to climate 2Princeton model anticipates ecological impacts of human responses to climate 3
(Date:7/14/2014)... 14, 2014 Throughout this past ... the clinical trials space, representing 38 countries globally, ... entitled “Optimizing Patient Participation in Clinical Trials. Attract. ... with internationally renowned R&D expert, Ken Getz, of ... Reinventing Drug Development through Patient Centricity. , Throughout ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... , for routine high fidelity amplification of up to 3.5 kb , ... 100 units , Cat. No. 1 664 955 ... , , Description , , , ... archaebacterium Pyrococcus woesei. The enzyme has a molecular weight of , ...
... , for routine amplification of up to 3 kb genomic DNA ... , , , , , ... contains 10 vials of 2x concentrated PCR reaction , mix (Taq ... dNTPs) plus water PCR grade (for dilution), sufficient for 100 , ...
... for amplification of up to 5 kb targets from genomic DNA ... , , , , , ... concentrated High Fidelity PCR Master contains all necessary , reagents ... a unique enzyme blend of Taq DNA Polymerase and Pwo DNA Polymerase[a thermostable , ...
Cached Biology Technology:Pwo DNA Polymerase 2Pwo DNA Polymerase 3PCR Master 2PCR Master 3High Fidelity PCR Master 2