Navigation Links
UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
Date:5/11/2010

two types of EHEC into the rumens of eight grain-fed adult cows. One mutant version lacked SdiA and could not detect the signal in the rumen. Another strain produced an enzyme that destroyed the chemicals in the rumen sensed by SdiA.

The researchers found that colonization diminished significantly when these EHEC strains were unable to sense the rumen chemicals. The process prevented the bacteria from moving on through the stomach and colonizing.

"If there's no signal, then there's no acid resistance, a requirement for the pathogen to make it to the recto-anal junction," Dr. Sperandio said. "Everybody had thought that this type of signaling occurred naturally in the gastrointestinal tract of mammals. Our finding serves as a proof-of-principle that we might be able to target this system to prevent food contamination."

EHEC, like other E coli strains, is usually transmitted through contaminated food. Recent outbreaks in the U.S. have been found in ground beef, spinach and raw sprouts. EHEC is responsible for outbreaks throughout the world of bloody diarrhea and hemolytic uremic syndrome a condition that can lead to renal failure and death. Severe symptoms are most common in children, the elderly and immune-suppressed people.

Cattle are the primary source for most E coli infections in the U.S. When cattle waste reaches water sources near food crops, contamination can occur. Unsanitary slaughtering of cattle also can lead to cross-contamination of the beef itself, and shipment of infected food speeds the rate at which the public can become ill.

Dr. Sperandio said the next step is to assess what happens to cows fed a grass-based, rather than grain-based, diet.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers identify key molecular step to fighting off viruses
2. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
3. New brain nerve cells key to stress resilience, UT Southwestern researchers find
4. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
5. UT Southwestern researchers find clues to TB drug resistance
6. American pika are thriving in the Sierra Nevada and southwestern Great Basin
7. Insect wranglers invade the garden at Southwestern science EXPO
8. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
9. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
10. The impact of the diffusion of maize to the Southwestern United States
11. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... fish purchased at retail seafood counters in 10 ... can expose consumers to unexpectedly high levels of ... falsely present a fish of the same species, ... dangerous mislabeling offense, according to new research by ... labeling of seafood is essential to allow consumers ...
(Date:8/19/2014)... -- ( Aug. 19, 2014 ) -- Scientists at ... to pick up and transfer single cells using a ... slightly. They describe this engineering feat and preliminary test ... of the American Chemical Society . , "Studying single ... in current biomedical research," said nanomedicine department. faculty member ...
(Date:8/19/2014)... who has ever had a glass of fizzy soda ... air. But in a finding with wide industrial applications, ... some particles down into the liquid as well. , ... droplets, so we were surprised, and fascinated, to discover ... same process injected tiny oil droplets into the water," ...
Breaking Biology News(10 mins):Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3Moving single cells around -- accurately and cheaply 2Bubbling down: Discovery suggests surprising uses for common bubbles 2Bubbling down: Discovery suggests surprising uses for common bubbles 3
... Washington DC (February 11, 2010) While many adults consider ... to be obese teens, saddling them with Type-2 diabetes, elevated ... this month in the journal Clinical Pediatrics (published ... point" in obesity often occurs before two years of age, ...
... Sultan, assistant professor of aerospace and ocean engineering at Virginia ... learn he has received a National Science Foundation (NSF) Faculty ... list of more than 70 Virginia Tech CAREER award winners, ... of Engineering since the award was created in 1994. He ...
... modifications to proteins called histones, which are found in ... which DNA is wound, can be used to predict ... pancreatic cancer, a study by researchers at UCLA,s Jonsson ... two specific histone modifications in tumor cells of patients ...
Cached Biology News:2 years old -- a childhood obesity tipping point? 2Engineer studies tensional integrity of biological structures 2Engineer studies tensional integrity of biological structures 3Predicting prognosis and treatment response in a subset of pancreatic cancer patients 2Predicting prognosis and treatment response in a subset of pancreatic cancer patients 3
(Date:8/19/2014)... , Aug. 19, 2014   Synthetic Biologics, ... developing novel anti-infective biologic and drug programs targeting ... announced today that its novel C. difficile ... 54 th Interscience Conference on Antimicrobial Agents ... Washington D.C. Synthetic Biologics, ...
(Date:8/18/2014)... -- A new therapy developed by researchers at ... of Medicine and Columbia University Medical Center (CUMC) ... cardiovascular disease treatment. , The researchers demonstrated ... therapy could selectively inhibit blood vessel re-narrowing and ... using a balloon catheter to open narrowed or ...
(Date:8/18/2014)... unprecedented efficiency and data storage may someday ... electric polarizations to read and write digital ... data-driven technology. But ferroelectrics must first overcome ... curious habit of "forgetting" stored data. ... of Energy,s Brookhaven National Laboratory have discovered ...
(Date:8/18/2014)... 2014 TNI BioTech, Inc. (OTC-BB: TNIB) ("we" ... and marketing of innovative therapies for autoimmune diseases in ... a second notice of TNI BioTech,s annual meeting of ... Noreen Griffin , founder and CEO of TNI ... participation in the Annual Meeting. On behalf of our ...
Breaking Biology Technology:Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 2Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 3Synthetic Biologics Announces Late-Breaking Poster Presentation for C. difficile Program at 54th ICAAC 4Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4
... N.C., Feb. 25 Attagene Inc., a,biotechnology ... analysis, announced today that one of the ... FACTORIAL(TM). In,advance online publication on Nature Methods, ... novel and remarkably consistent method for,simultaneously reporting ...
... 25 t2cure, a clinical,stage biopharmaceutical company developing ... today that it has appointed,Dr. Petra Rueck Head ... have Petra join our company", said Manfred Ruediger,CEO ... project,management will be of critical importance to t2cure ...
... ADVENTRX Pharmaceuticals,Inc. (Amex: ANX ) announced today that ... President of ImClone Systems Incorporated, will,join its Board of ... size of its Board from six to seven directors., ... Board of Directors. He brings,tremendous knowledge and expertise within ...
Cached Biology Technology:Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods 2Attagene's Breakthrough Transcription Factor Profiling Technology to be Described in Nature Methods 3Stem Cell Company t2cure Appoints Dr Rueck Head of Clinical Operations 2Eric K. Rowinsky Joins ADVENTRX Board of Directors 2Eric K. Rowinsky Joins ADVENTRX Board of Directors 3Eric K. Rowinsky Joins ADVENTRX Board of Directors 4