Navigation Links
UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
Date:5/11/2010

DALLAS May 11, 2010 Microbiologists at UT Southwestern Medical Center, working with the Department of Agriculture, have identified a potential target in cattle that could be exploited to help prevent outbreaks of food-borne illnesses caused by a nasty strain of Escherichia coli.

In the study, available online and in an upcoming issue of the Proceedings of the National Academy of Sciences, researchers interfered with a genetic sensing mechanism that allows the E. coli strain known as enterohemorrhagic O157:H7, or EHEC, to form colonies within cattle, causing the bacteria to die off before they could reach the animals' recto-anal junction, the primary site of colonization. Most other strains of E coli gather in the colon.

"We're diminishing colonization by not letting EHEC go where it needs to go efficiently," said Dr. Vanessa Sperandio, associate professor of microbiology and biochemistry at UT Southwestern and senior author of the study. "If we can find a way to prevent these bacteria from ever colonizing in cattle, it's possible that we can have a real impact on human disease.

"This could be something as simple as including some sort of antagonist in cattle feed, which would result in less shedding of the bacteria in fecal matter with less contamination down the road in food products."

Dr. Sperandio said the finding is important because an estimated 70 percent to 80 percent of the cattle herds in the U.S. carry EHEC.

Although EHEC can be a deadly pathogen to humans, the bacterium is part of cattle's normal gastrointestinal flora. EHEC harbors a gene called sdiA, which makes the SdiA protein. The SdiA protein senses a chemical made by microbes in the animal's rumen, the first of a cow's four stomachs, which serves as a large fermentation chamber. Detecting this signal allows EHEC to pass through the rumen and colonize the recto-anal junction.

For the study, the researchers injected
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers identify key molecular step to fighting off viruses
2. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
3. New brain nerve cells key to stress resilience, UT Southwestern researchers find
4. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
5. UT Southwestern researchers find clues to TB drug resistance
6. American pika are thriving in the Sierra Nevada and southwestern Great Basin
7. Insect wranglers invade the garden at Southwestern science EXPO
8. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
9. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
10. The impact of the diffusion of maize to the Southwestern United States
11. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the fourth quarter ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, ... ), the leading developer of human interface ... authentication technology, the industry,s first fully hardware ... innovative Match-in-Sensor secure authentication technology is literally ... pattern storage and biometric matching within the ...
(Date:7/8/2015)...  Trovagene, Inc. (NASDAQ: TROV ), a ... launch of a study that aims to determine ... technology for predicting response to treatment in advanced ... the novel immunotherapy agents Yervoy® (ipilumumab), a CTLA-4 ... 50-patient study will be led by researchers at ...
Breaking Biology News(10 mins):Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... poisonous frog was recently discovered in a remote mountainous ... supported by the Conservation Leadership Programme (CLP). The new ... given the name the ?golden frog of Supat. ... to several other common species in the area. However, ...
... of highly organized epithelial cells line all the cavities ... the movement of liquids,and cells in the body organs. ... serve as a barrier against cancer, according to a,study ... week in,the online edition of the Proceedings of the ...
... today by the Health Department shed new light on the ... who responded to the World Trade Center disaster on September ... Health Registry, show that 3.6% of the 25,000 rescue and ... working at the site. That rate is 12 times what ...
Cached Biology News:Cells united against cancer 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 2Survey finds elevated rates of new asthma among WTC rescue and recovery workers 3
(Date:8/3/2015)... ... August 03, 2015 , ... Sterlitech Corporation introduces ... comprehensive line of analytical laboratory equipment. With optimized features, such as PTFE-coated contact ... chemically resistant and maintenance-free solution for a broad range of vacuum filtration applications. ...
(Date:7/31/2015)... , July 31, 2015 In ... resources that help them drive positive health outcomes, ... vital source of patient care in their communities. ... annual tradeshow and conference, AmerisourceBergen announced a new ... Pharmacy Services Administration Organization and help independent pharmacies ...
(Date:7/31/2015)... ... 31, 2015 , ... Global Resorcinol Market 2015-2019 is a ... the global resorcinol industry. The report highlights the various growth prospects and the ... analysis of primary and secondary inputs from the existing players of the resorcinol ...
(Date:7/31/2015)... July 31, 2015 China Cord Blood Corporation ... leading provider of cord blood collection, laboratory ... services, today announced that the Company has filed its ... and Exchange Commission. The filed Form 20-F includes audited ... 2015. The Form 20-F can be accessed by visiting ...
Breaking Biology Technology:Sterlitech Launches New Line of Vacuum Pumps 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 2Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 3Resorcinol Market to Grow at 6% CAGR to 2019 Says New Research Report at ReportsnReports.com 4China Cord Blood Corporation Files Its Annual Report on Form 20-F 2
... Research conducted at The,Walter and Eliza Hall ... licensing agreement signed between Australian biotechnology company,Bionomics, ... Under the Development and Licensing Agreement, Merck ... multiple sclerosis (MS) and other autoimmune,conditions. These ...
... -- WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology ... operations in China and the United,States, today announced ... Vice President,of Human Resources., (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... Mr. Zhu worked as Head of Asia Human,Resources ...
... Antonio (June 30, 2008) Researchers at The University of ... Infectious Diseases and The University of Texas Health Science Center ... to play a role in controlling the early infectious process ... agent that is the cause of tularemia. The findings will ...
Cached Biology Technology:MS Drug Development Agreement Based on WEHI's Medicinal Chemistry 2WuXi PharmaTech (NYSE: WX) Appoints Mr. Bob Zhu as VP of HR 2UTSA/UTHSCSA publish results on bio-threat agent 2