Navigation Links
UT Southwestern researchers examine mechanisms that help cancer cells proliferate
Date:9/1/2009

DALLAS Sept. 1, 2009 A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell.

Most cells in the human body divide only a certain number of times, via a countdown mechanism that stops them. When the controlling process goes wrong, the cells divide indefinitely, contributing to cancer growth.

The number of times a cell divides is determined by special segments of DNA called telomeres, which are located at the ends of each chromosome. Every time a cell divides, the telomeres get shorter. When they are reduced to a certain length, the cell stops dividing.

In the new study, UT Southwestern researchers used both normal and cancerous human cells to examine closely how telomeres behave during cell division.

As a cell prepares to divide into two new cells, its ladder-shaped DNA "unzips," creating two halves, each resembling a single upright of a ladder with a set of half-length rungs. Fresh genetic material then fills in the rungs and a second upright. This process creates two identical sets of chromosomes that will be allotted between the two cells.

From earlier studies on model organisms such as yeast, scientists thought that all telomeres replicated late in the stage of overall DNA replication, and by the same processes. The new study suggests that telomeres replicate at various times during this stage, except for a final step that is not completed until the very end, via a different, unknown mechanism.

"Interfering with replication of telomeres might provide a way to halt uncontrolled spread of cancer cells," said Dr. Woodring Wright, professor of cell biology at UT Southwestern and co-senior author of the paper.

The researchers also examined an enzyme called telomerase, which "rebuilds" telomere
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researchers identify hundreds of genes controlling female fertility
2. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
3. UT Southwestern secures $5 million NIH grant for lupus research
4. UT Southwestern scientist honored among best in Texas research
5. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
6. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
7. UT Southwesterns Mangelsdorf elected to National Academy of Sciences
8. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
9. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
10. Geology and biology meet in the history of US southwestern desert surface waters
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Sept. 18, 2014 -- Arizona turned its newborn screening program ... few short months, earning it the first-ever Newborn Screening Quality ... of Dimes presented Will Humble, M.P.H., Arizona,s Department of Health ... today. Mr. Humble established a policy of full transparency for ... newborn blood samples to the lab for analysis, and set ...
(Date:9/18/2014)... of carbon and nitrogen comprise all spheres of ... systems have caused imbalances and perturbations that resulted ... Increased GHGs result in climate changes which influence ... and the atmosphere. Understanding these feedback mechanisms has ... environmental science during the past three decades. , ...
(Date:9/18/2014)... can swim up to 400 kilometres in search of a ... change. , Clownfish spend their entire adult lives under the ... wander the open ocean, says study co-author, Dr Hugo Harrison ... (Coral CoE) at James Cook University. , "In the past ... given a rare glimpse into how far they can swim, ...
Breaking Biology News(10 mins):March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3Greenhouse gas research enters a new era 2Nemo's epic journey to find a new home 2
... A team led by researchers at the University ... the "superbug" methicillin-resistant Staphylococcus aureus (MRSA) is ... is well known for causing difficult-to-treat and potentially fatal ... 1990s it has also been infecting otherwise healthy people ...
... study shows for the first time that episodes of ... the 2001-02 drought, greatly accelerated development of the mountain ... to chart the evolution of the current pine beetle ... beetle outbreak in the two primary host species, the ...
... a daily multivitamin, but little is known about a multivitamin,s ... Brigham and Women,s Hospital (BWH) finds that daily multivitamin use ... A similar BWH study, announced last month, found daily ... 8 percent. The cardiovascular disease findings will be presented ...
Cached Biology News:Superbug MRSA identified in US wastewater treatment plants 22001-2002 drought helped propel mountain pine beetle epidemic, says CU study 22001-2002 drought helped propel mountain pine beetle epidemic, says CU study 32001-2002 drought helped propel mountain pine beetle epidemic, says CU study 4Daily multivitamin use does not reduce cardiovascular disease risk in men 2
(Date:9/19/2014)... , Sept. 19, 2014 Pfenex Inc. ... the development of high-value and difficult to manufacture proteins ... presenting at the 21 st Annual NewsMakers in ... . Bertrand Liang , chief executive officer ... development programs and business strategy on Friday, September 26, ...
(Date:9/19/2014)... September 19, 2014 Barnhardt Manufacturing ... Label for its Organic Cotton . The USDA ... of renewable biobased ingredients meets or exceeds levels set ... composed in whole or in significant part of agricultural, ... allow our Organic cotton to be immediately identified as ...
(Date:9/19/2014)... , September 19, 2014 ... Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition of ... Columns"  report to their offering.       ... is one of the fastest-growing segments in the ... billion in 2013, and expected to reach $2.0 ...
(Date:9/19/2014)... September 19, 2014 The new , ... , available today on PharmaBoardroom.com for ... crisis that rocked the Spanish economy in 2009, and the ... community has remained pragmatic in times of trouble. ... the fifth biggest European market, and the general conditions to ...
Breaking Biology Technology:Pfenex to Present at Upcoming Industry Conference on September 26 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3
... (Nasdaq: SGMO ) today reported second quarter 2011 ... quarter ended June 30, 2011, Sangamo reported a consolidated net ... a net loss of $3.9  million, or $0.09 per share, ... 2011, the company had cash, cash equivalents and marketable securities ...
... 2011 Once routinely discarded during the birth process, ... life-saving stem cells that can be collected and stored ... and vast medical potential, published data shows that three ... about cord blood banking. In connection with ...
... Calif., July 26, 2011 Synterra Energy, Inc. ... and assets for waste biomass conversion from Pacific ... Lion Bio-Energy (Toledo, Ohio).  With the merger, Synterra ... bio-refineries for the economic production of renewable fuels, ...
Cached Biology Technology:Sangamo BioSciences Reports Second Quarter 2011 Financial Results 2Sangamo BioSciences Reports Second Quarter 2011 Financial Results 3Sangamo BioSciences Reports Second Quarter 2011 Financial Results 4Sangamo BioSciences Reports Second Quarter 2011 Financial Results 5Sangamo BioSciences Reports Second Quarter 2011 Financial Results 6Sangamo BioSciences Reports Second Quarter 2011 Financial Results 7Parent's Guide to Cord Blood Foundation Launches Nation's First Searchable Map of U.S. Sites for Donating Umbilical Cord Blood 2Parent's Guide to Cord Blood Foundation Launches Nation's First Searchable Map of U.S. Sites for Donating Umbilical Cord Blood 3Synterra Energy Merges Key Technologies to Commercialize Next Generation Integrated Bio-refinery 2
... SNPstream System Delivers 4,600 to Over 3 ... Genotyping System is capable of performing 4,600 ... Part of the GenomeLab family of products*, ... up to 48 SNPs in each well ...
Mouse monoclonal antibody to ACP2 - acid phosphatase 2, lysosomal...
Mouse monoclonal antibody to DCAMKL2 - doublecortin and CaM kinase-like 2...
... Tube Disperser System from IKA Works is the ... cleaner, safer, and more efficient way to disperse ... 2 to 15 ml inside sealed tubes. Depending ... of 4 different tube types. Each tube is ...
Biology Products: