Navigation Links
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
Date:1/30/2009

DALLAS Jan. 30, 2009 Screening a chemical library of 200,000 compounds, researchers at UT Southwestern Medical Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases.

"The identification of these chemicals and their targets within this cellular pathway represents an important step in developing therapeutic agents," said Dr. Lawrence Lum, assistant professor of cell biology and senior author of the study, available at Nature Chemical Biology.

The researchers studied biochemical reactions within cells controlled by a class of proteins called Wnt (pronounced "wint"). Wnt proteins help control embryonic development in many animals, including humans. In adults, these proteins also sustain the vital supply of stem cells that replenish various body tissues. Misregulation of cellular responses to Wnt proteins, however, is associated with a broad range of diseases including Alzheimer's and polycystic kidney disease, cancer and type 2 diabetes.

In the current study, the researchers used cultured mouse cells that were engineered to glow green when Wnt-controlled pathways were active. A robotic device then tested 200,000 compounds to measure their effects on the cells.

Nine compounds that inactivated Wnt-controlled systems thus preventing the cells from glowing were earmarked for further research. The researchers then found that five of these compounds stopped cells from responding to Wnt, and four prevented Wnt from being produced in the first place.

"The ability to attack this disease pathway at two distinct regulatory steps is an important step toward realizing personalized medicine that aims to tailor the use of drugs for specific genetic mutations," Dr. Lum said.

Importantly, the action of these compounds is reversible, the researchers found. "This may allow us to target diseased cells without permanently altering the function of normal stem cells," Dr. Lum said.

Despite these encouraging results, there is a long way to go before these compounds could be the basis of new drugs, Dr. Lum said. The researchers plan to make variations of these compounds to see if they can be effective at lower doses, and they also will perform additional studies in whole animals, he said.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. UT Southwestern scientist honored among best in Texas research
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
6. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
7. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
8. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
9. Limiting fructose may boost weight loss, UT Southwestern researcher reports
10. UT Southwestern researchers identify new targets for RNAs that regulate genes
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
(Date:2/1/2016)...  Today, the first day of American Heart Month, ... a first of its kind workplace health solution that ... the first application of Watson ... and Welltok will create a new offering that combines ... delivered on Welltok,s health optimization platform. The effort is ...
(Date:1/25/2016)... -- Glencoe Software, the world-leading supplier of image data management ... the data management solution OMERO Plus for the newly ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... Phenotypic analysis measures the characteristics and behavior of cells, ... such as health and disease, the presence or absence ...
(Date:1/20/2016)... Minn. , Jan. 20, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... 2015. MedNet,s significant achievements are the result of the ... iMedNet eClinical , it,s comprehensive, easy-to-use ... --> --> Key MedNet growth achievements ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 11, 2016   BioInformant announces the February ... Research Products, Opportunities, Tools, and Technologies – Market Size, ... The first and ... cell industry, BioInformant has more than a decade of ... market, by stem cell type. This powerful 175 page ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... a new agreement with Bankok,Thailand-based Global Stem Cells Network (GSCN) to distribute exosome ... Latin American countries, including Mexico, Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, ...
(Date:2/10/2016)... MONTREAL , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. ... is pleased to announce that Mitsui & Co. Ltd., ... bio-based succinic acid plant, is investing an additional CDN$25 ... equity, increasing its stake from 30% to 40%.  Mitsui ... of bio-succinic acid produced in Sarnia ...
(Date:2/10/2016)... Feb. 10, 2016  The Maryland House of Delegates ... announced that University of Maryland School of Medicine Dean ... University of Maryland Medical System President and CEO ... Medallion," the highest honor given to the public by ... Dean Reece and Mr. Chrencik for their ...
Breaking Biology Technology: