Navigation Links
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
Date:1/30/2009

DALLAS Jan. 30, 2009 Screening a chemical library of 200,000 compounds, researchers at UT Southwestern Medical Center have identified two new classes that can be used to study and possibly manipulate a cellular pathway involved in many types of cancer and degenerative diseases.

"The identification of these chemicals and their targets within this cellular pathway represents an important step in developing therapeutic agents," said Dr. Lawrence Lum, assistant professor of cell biology and senior author of the study, available at Nature Chemical Biology.

The researchers studied biochemical reactions within cells controlled by a class of proteins called Wnt (pronounced "wint"). Wnt proteins help control embryonic development in many animals, including humans. In adults, these proteins also sustain the vital supply of stem cells that replenish various body tissues. Misregulation of cellular responses to Wnt proteins, however, is associated with a broad range of diseases including Alzheimer's and polycystic kidney disease, cancer and type 2 diabetes.

In the current study, the researchers used cultured mouse cells that were engineered to glow green when Wnt-controlled pathways were active. A robotic device then tested 200,000 compounds to measure their effects on the cells.

Nine compounds that inactivated Wnt-controlled systems thus preventing the cells from glowing were earmarked for further research. The researchers then found that five of these compounds stopped cells from responding to Wnt, and four prevented Wnt from being produced in the first place.

"The ability to attack this disease pathway at two distinct regulatory steps is an important step toward realizing personalized medicine that aims to tailor the use of drugs for specific genetic mutations," Dr. Lum said.

Importantly, the action of these compounds is reversible, the researchers found. "This may allow us to target diseased cells w
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
2. UT Southwestern scientist honored among best in Texas research
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
6. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
7. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
8. Antidepressants need new nerve cells to be effective, UT Southwestern researchers find
9. Limiting fructose may boost weight loss, UT Southwestern researcher reports
10. UT Southwestern researchers identify new targets for RNAs that regulate genes
11. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
(Date:8/21/2014)... pancreas digesting itself resulting in severe abdominal pain, vomiting ... 20,000 patients are diagnosed with the disease resulting in ... is restricted to intravenous fluid and nutritional support. ... Sciences, who led the research, said "The major causes ... and excessive alcohol intake combined with a high fat ...
(Date:8/20/2014)... SALT LAKE CITY Researchers at Huntsman Cancer Institute (HCI) ... mutated forms of the gene that encodes BCR-ABL, the ... (CML). According to the American Cancer Society, nearly 6,000 ... , Drugs already in use, called tyrosine kinase inhibitors ... disease. They do not cure CML but control it ...
(Date:8/20/2014)... State University, the Wellcome Trust Sanger Institute and the ... Mycobacterium pinnipedii from skeletons found in Peru ... is a relative of the TB bacterium that affects ... These researchers assume that seals carried the pathogens from ... lions was unexpected" comments Sebastien Gagneux, from the Swiss ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... heart having limited ability to regenerate following injury, heart disease ... developed world. Research impacting strategies for heart repair will be ... Houston (UH). Eric N. Olson, a molecular biologist ... "Heart Making and Heart Breaking: New Strategies for Heart Repair." ...
... Tampa, Fla. (May. 8, 2012) Two studies appearing ... (20:11-12), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ , ... that may make them therapeutically useful and appropriate for ... immature dental pulp stem cells , A ...
... Angeles, CA (May 8, 2012) A new study from ... when men chair committees that select scientific awards recipients, males ... new study also reports that while in the past two ... scientific achievements, compared to men, they win more service and ...
Cached Biology News:New heart repair strategies discussed at UH lecture May 15 22 Cell Transplantation studies impact dental stem cell research for therapeutic purposes 22 Cell Transplantation studies impact dental stem cell research for therapeutic purposes 3Women's scientific achievements often overlooked and undervalued 2
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
(Date:8/20/2014)... 20, 2014 The 6th Annual ... held on October 29-30 in San Francisco, CA. This ... and government researchers and clinicians focused on addressing and ... , In the twelve years since the sequencing of ... been introduced with pharmacogenetic information in the label and ...
(Date:8/20/2014)... in your ear could improve the health of your ... University of Leeds used a standard TENS machine like ... pulses to the tragus, the small raised flap at ... the ear canal. , The stimulation changed the influence ... the nervous signals that can drive failing hearts too ...
(Date:8/19/2014)... Piscataway, NJ (PRWEB) August 20, 2014 ... engineering and regenerative medicine is an inadequate vascular ... engineered constructs and decellularized tissues is critical for ... Researchers have attempted to mitigate deficiencies in vascularization ... including adding scaffold bioactivity, optimizing scaffold design and ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2
... 11, 2008 RiverVest Venture Partners,announced today that ... Venture Fund II, L.P., with total committed capital ... which was licensed,as a Small Business Investment Company, ... tier of leverage from the Small Business Administration., ...
... CAMBRIDGE, Mass., April 11 Biopure,Corporation (Nasdaq: ... United Kingdom,s,Medicines and Healthcare products Regulatory Agency ... to be in general compliance,with the principles ... in the Commission Directives. The company received ...
... Renowned Clinic Invests in Extracranial Radiosurgery, SUNNYVALE, ... ), a global leader in the field of ... part of the renowned,Hirslanden group of private hospitals, ... System sold in Switzerland, allowing patients greater,access to ...
Cached Biology Technology:RiverVest Venture Partners(R), a St. Louis-Based Venture Capital Firm Focusing on Life Sciences, Closes on Fund II, Names John P. McKearn, Ph.D., Venture Partner 2RiverVest Venture Partners(R), a St. Louis-Based Venture Capital Firm Focusing on Life Sciences, Closes on Fund II, Names John P. McKearn, Ph.D., Venture Partner 3Biopure Operations Compliant With U.K. Manufacturing Guidelines 2Biopure Operations Compliant With U.K. Manufacturing Guidelines 3First CyberKnife System Sold in Switzerland 2First CyberKnife System Sold in Switzerland 3First CyberKnife System Sold in Switzerland 4
GRADIENT MAKER, 30 ML, 1 EA. Category: Protein Vertical Instruments....
Recombinant Rat Leptin, CF...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
...
Biology Products: