Navigation Links
UT Southwestern researchers create molecule that nudges nerve stem cells to mature
Date:6/15/2008

DALLAS June 15, 2008 Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture.

This finding might someday allow a person's own nerve stem cells to be grown outside the body, stimulated into maturity, and then re-implanted as working nerve cells to treat various diseases, the researchers said.

"This provides a critical starting point for neuro-regenerative medicine and brain cancer chemotherapy," said Dr. Jenny Hsieh, assistant professor of molecular biology and senior author of the paper, which appears online today and in the June 17 issue of Nature Chemical Biology.

The creation of the molecule allowed the researchers to uncover some of the biochemical steps that happen as nerve cells mature. It also showed that large-scale screening of compounds can provide starting points for developing drugs to treat disorders such as Huntington's disease, traumatic brain injury or cancer.

The scientists began this project as a result of a separate study in which they were screening 147,000 compounds to see which could stimulate stem cells cultivated from rodent embryos to become heart cells. Unexpectedly, five molecules stimulated the cells to transform into forms resembling nerve cells. The researchers then created a variation of these molecules, a new compound called Isx-9 (for isoxazole-9). Isx-9 was easier to use than its initially discovered relatives because it worked at a much lower concentration and also dissolved more easily in water.

"It was completely serendipitous that we uncovered this neurogenic [nerve-creating] small molecule," Dr. Hsieh said. "I think it's one of the most powerful neurogenic small molecules on the planet. In theory, this molecule could provoke full maturation, to the point that the new nerve cells could fire, generating the electric
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Geology and biology meet in the history of US southwestern desert surface waters
2. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
3. Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
4. UT Southwesterns Mangelsdorf elected to National Academy of Sciences
5. NIH awards $6.5 million grant to UT Southwestern to develop new antibiotic
6. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
7. UT Southwestern scientist honored among best in Texas research
8. UT Southwestern secures $5 million NIH grant for lupus research
9. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
10. UT Southwestern researchers identify hundreds of genes controlling female fertility
11. Researchers reveal insights into hidden world of protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/143028 for MINIATURE, MULTI-PURPOSE ... TRANSFER  NXT-ID introduces a new revolutionary ... patent surrounds the use of miniature antenna modules ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... smart wallets is underway to early access pre-order customers. ... includes usage at retail outlets including Walmart, Target, AT&T, ... report Wocket was accepted at all outlets and very ...
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... a study in her lab showed that mate (mah ... the activity of an enzyme that promotes HDL (good) ... scientist Elvira de Mejia headed for Argentina where mate ... She returned with a five-year agreement signed by ...
... rare Amur leopard (Panthera pardus orientalis), one of only ... captured and health-checked by experts from a consortium of ... group of organizations, including the Russian Academy of Sciences ... (WCS) and the Zoological Society of London (ZSL) captured ...
... more than 50 Earth Observation satellites is increasing ... synoptic views of our planet. Because these satellites ... analysis and environmental monitoring can be difficult, making ... Calibration and Validation processes. More than 50 ...
Cached Biology News:More on mate tea: lower cholesterol and an international agreement 2Critically endangered Amur leopard captured 2A roadmap for calibration and validation 2
(Date:5/1/2015)... DIEGO , May 1, 2015 ... company engaged in the development of biosimilar therapeutics ... announced today that its first quarter 2015 financial ... 2015, before the open of market. At 8:30 am ... call to discuss the financial results and provide ...
(Date:5/1/2015)... 2015 A new report by  ... will reach $22.4bn in 2019. That revenue forecast and ... Market Prospects 2015-2025 ,  published in March ... to provide forecasts and qualitative analyses of the antithrombotic ... consultancy in London, UK . It ...
(Date:5/1/2015)... N.Y. , May 1, 2015 Albany ... that William S. Marth , AMRI,s President and ... America Merrill Lynch 2015 Health Care Conference on Wednesday, ... A live audio webcast of the presentation can be ...          The webcast will be archived ...
(Date:5/1/2015)... Md. and RESEARCH TRIANGLE PARK, N.C. ... UTHR ) announced today that Roger Jeffs , ... provide an overview and update on the company,s business at ... in Boston, Massachusetts . The ... 3:30 PM Eastern Time, and can be accessed via a ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2
... Household planning will accomplish more in preparing for the ... than will any reliance on information technology, attendees of ... , ,Panelists talked about being three years late in ... effects of a flu pandemic, which would cause significant ...
... Carlos Santiago that research projects on his campus will ... probably laugh at you. , ,"Let's get real," Santiago ... future of higher education in Wisconsin. "(UW-Milwaukee research programs) ... different periods of their evolution." , ,Likewise, don't suggest ...
... ruled in favor of an American computer giant in its long-running ... Beatles established in the 1960s to protect their commercial interests. , ... entitled to use the apple logo on its iTunes Music Store, ... on a 1991 agreement, offers nothing new of any legal significance ...
Cached Biology Technology:IT may take a back seat in fighting avian flu 2IT may take a back seat in fighting avian flu 3IT may take a back seat in fighting avian flu 4Why Milwaukee needs its own thriving research base 2Why Milwaukee needs its own thriving research base 3Apple Computer may use Apple logo on iTunes 2
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
... monitoring Aldolase tests. 2 levels of ... manufacturing values at 4 ± 2 ... 30-day shelf life once opened ... 1: 3 x 3 ml; Level ...
Human VEGF-D Biotinylated MAb (Clone 78923)...
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
Biology Products: