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UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
Date:10/22/2008

d, they will be attached to "carriers" and tested in mice to determine whether they can actually elicit antibodies that neutralize the pathogen. Dr. Vitetta said the challenge and novelty of this approach is to demonstrate that these anti-peptoid antibodies can mimic those the body produces against the actual native pathogen and confer protective immunity.

"This is high-risk, high-impact research, meaning that there is a high risk of failure," Dr. Vitetta said. "But if our experiments are successful, we hope to identify peptoid mimetics that recognize all variants of HIV, and if we are extremely lucky, we will have a useful vaccine for HIV, which will have tremendous impact. Our work could also open the door for vaccines against other pathogens, such as West Nile virus, hepatitis C and influenza. Even if we fail entirely, we will gain a great deal of insight into what we need to do to make mimetic vaccines work."


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Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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