Navigation Links
UT Southwestern research reveals that significantly more genetic mutations lead to colon cancer
Date:7/17/2011

DALLAS July 18, 2011 Researchers at UT Southwestern Medical Center say there are at least 70 genetic mutations involved in the formation of colon cancer, far more than scientists previously thought.

Based on the study, published in the July 2011 Cancer Research (Priority Reports), researchers are suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously. Current cancer treatments target just one or two known cancer-driver genes believing this would be beneficial to patients. While patients may get transient tumor burden reduction, almost universally tumor growth returns.

The UT Southwestern research contradicts previous thinking that only a few mutated genes are important in the development of cancerous tumors.

"The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.

Under the old model, scientists believed there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.

"Those numbers are dead wrong," Dr. Shay said. According to UT Southwestern's research, there are 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor-suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.

The next step is further research to classify more accurately which genes drive cancer and which are merely passengers.


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1

Related biology news :

1. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
2. UT Southwestern researchers find protein that might be key to cutting cancer cells blood supply
3. UT Southwestern research reveals how cancer-driving enzyme works
4. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
5. Team of scientists predicts continued death of forests in southwestern US due to climate change
6. UT Southwestern researchers uncover culprits in life-threatening clotting disorder
7. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
8. UT Southwestern researchers find key step in bodys ability to make red blood cells
9. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
10. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
11. UT Southwestern researchers identify key molecular step to fighting off viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... body. Battles are won, lost or sometimes end ... as tumor dormancy—can last up to 25 years ... poorly understood. , A new computational model ... Professor of Chemistry at Princeton University, may help ... switch to a malignant state. Published today in ...
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
Breaking Biology News(10 mins):Sperm wars 2Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2
... is a dancer,s instrument, but is it attuned to the ... suggests that professional ballet and modern dancers are not as ... regularly practice meditation. UC Berkeley researchers tracked how closely ... changes such as breathing and heart rates. They found ...
... A team involving University of Tennessee, Knoxville, researchers ... algal bloom (HAB) species, cracking the genome of the ... Brown tides decimated the scallop industries of New ... and continue to plague the waters off North America ...
... is central to cell function, as it converts the information ... which then program protein synthesis. The enzyme RNA polymerase II ... prone to transcriptional arrest. The biochemist Professor Patrick Cramer, Director ... have now shown for the first time and captured ...
Cached Biology News:Meditation beats dance for harmonizing body and mind 2UT researchers crack code to harmful brown tides 2Stop and go 2
(Date:10/22/2014)... -- Nuvilex, Inc. (OTCQB: NVLX) – According to the ... living with diabetes, with  that number expected to grow ... for diabetes treatments is approximately $500 billion.  ... pancreatic cancer.  Pancreatic cancer is the fourth most common ... the United States , and according to a ...
(Date:10/20/2014)... Oct. 20, 2014 Mapp Biopharmaceutical,s valiant ... antibody therapeutic to fight the Ebola outbreak will ... time-consuming the production of pharmaceuticals can be, according ... said that while some may be taken aback ... those with industry knowledge are well aware of ...
(Date:10/20/2014)... , October 20, 2014 ... gastrointestinal (GI) disorders and the delivery of care has ... diseases and worrying inequalities in the provision of healthcare ... which was commissioned by United European Gastroenterology (UEG), have ... political and public awareness of the burden of GI ...
(Date:10/20/2014)... Virginia (PRWEB) October 20, 2014 ... NDA Partners LLC, announced today that Ellen Teplitzky, ... legal support for the pharmaceutical industry, has joined ... manager of its legal services practice. NDA ... and expert witness and testimony, to top law ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... Life Length®, the world,s leading telomere testing ... Inc ("ADL") of Boca Raton, Florida to offer its test ... tissue samples to be forwarded to Life Length,s lab in ... Length said, "We are delighted to partner with ADL. This ...
... Inc. today announced that two studies of SL-401, a ... malignancies, have also demonstrated preclinical activity against a variety ... at the upcoming 53rd Annual Meeting of the American ... Diego, CA from December 10-13, 2011. ...
... RATON, Fla., Dec. 7, 2011 /PRNewswire-iReach/ -- ... Herb Pharma, Switzerland: the best and most powerful weapons ... Although aging is a natural process, no-one ... neck and decolletage, which are on display most of ...
Cached Biology Technology:Life Length Telomere Test Available Nationwide 2Stemline Therapeutics, Inc. Announces Two Poster Presentations of SL-401 Efficacy Data Against Lymphoid Cancers at the 53rd Annual Meeting of the American Society of Hematology (ASH) 2Stemline Therapeutics, Inc. Announces Two Poster Presentations of SL-401 Efficacy Data Against Lymphoid Cancers at the 53rd Annual Meeting of the American Society of Hematology (ASH) 3Stemline Therapeutics, Inc. Announces Two Poster Presentations of SL-401 Efficacy Data Against Lymphoid Cancers at the 53rd Annual Meeting of the American Society of Hematology (ASH) 4Fytofontana Cosmeceuticals: The Swiss Secret For Incredibly Young And Beautiful Skin 2
... MiniPrep series of robotic workstations is designed ... MiniPrep is the ideal automation platform for ... routine laboratory procedures, improving throughput, process consistency ... for MiniPrep software allows you to control ...
Mouse polyclonal antibody to TNPO2 - transportin 2 (importin 3, karyopherin beta 2b)...
...
... HDAC4 - ChIP Grade HDAC4 is ... histone deacetylases, which consists of 1084 amino ... similar to the deacetylase domain of yeast ... the nucleus and cytoplasm in a process ...
Biology Products: