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UT Southwestern research reveals how cancer-driving enzyme works
Date:5/6/2011

-repair activity. Cajal bodies assemble ribonucleic acid (RNA) within proteins.

"Telomerase uses this RNA in order to add the sequences onto the end, and this complex is assembled or modified in some way in these Cajal bodies," Dr. Wright said.

UT Southwestern scientists next will work to pinpoint the precise molecules that bring telomerase to telomeres for potential development of inhibitors that would be new cancer drugs.

"We now need to find the molecules that are doing that as targets for additional inhibitors," Dr. Wright said. "We have identified the step, but we haven't yet identified the molecules involved."

One drug that blocks telomerase, Imetelstat or GRN163L, was developed by the biotechnology company Geron with help from Drs. Wright and Jerry Shay, professor of cell biology. That drug, tested at UT Southwestern, is currently in clinical trials for treatment of several types of cancer.


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Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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