Navigation Links
UT Southwestern research reveals how cancer-driving enzyme works
Date:5/6/2011

DALLAS May 6, 2011 Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.

Their latest findings, published today in Molecular Cell, demonstrate that telomerase repairs chromosomes in one of two ways depending on whether a cell is dividing normally or if the cell is under stress from enzyme inhibition and could lead to new or improved cancer-fighting therapies that promote inhibition of this enzyme.

"It's a significant advance in our understanding of how telomerase works," said Dr. Woodring Wright, professor of cell biology and senior author of the study. "Our goal is to identify new targets for inhibiting telomerase."

The number of times a cell divides is determined by telomeres, protective caps on the ends of chromosomes that indicate cell age. Every time a cell divides, the telomeres shorten. When telomeres shrink to a certain length, the cell either dies or stops dividing. In cancer cells, the enzyme telomerase keeps rebuilding the telomeres, so the cell never receives the cue to stop dividing.

Although telomerase was discovered in 1985, exactly how this enzyme repairs telomeres to enable cancer cells to divide and grow was largely unknown. Until now, researchers didn't know how many telomerase molecules went into action at the telomeres and under what conditions.

"It's a single molecule under normal cancer growth conditions, but if you shorten telomeres artificially by inhibiting telomerase, now it's more than one molecule acting on the ends of the telomeres," Dr. Wright said of the study's findings.

When acting as a single molecule at the telomeres, telomerase adds about 60 nucleotide molecules "in one fell swoop to the end of the chromosome," Dr. Wright said.

Researchers also discovered that structures in cells called Cajal bodies help process telomerase during chromosome
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
2. Team of scientists predicts continued death of forests in southwestern US due to climate change
3. UT Southwestern researchers uncover culprits in life-threatening clotting disorder
4. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
5. UT Southwestern researchers find key step in bodys ability to make red blood cells
6. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
7. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
8. UT Southwestern researchers identify key molecular step to fighting off viruses
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. New brain nerve cells key to stress resilience, UT Southwestern researchers find
11. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich report that ... cells more sensitive to chemotherapeutic drugs. They have ... a new target for anti-tumor agents. , ... Professor Stephan Sieber of the Technische Universitt Mnchen ... a potential new weapon in the fight against ...
(Date:9/30/2014)... news release is available in German . ... in their behavioural response to risky situations such as ... for Ornithology now found in a long-term study on ... with both metabolic rate and ambient temperature. High metabolic ... behaviour, as in these scenarios birds were more likely ...
(Date:9/30/2014)... People who suffer from asthma may think there,s not ... besides properly taking medications and avoiding allergic triggers. ... Annals of Allergy, Asthma and Immunology , the scientific ... Immunology (ACAAI), asthma sufferers can learn lessons about managing ... in the Annals article improved her asthma once she ...
Breaking Biology News(10 mins):Cancer therapy: Driving cancer cells to suicide 2Risky metabolism 2Asthma symptoms kicking up? Check your exposure to air pollution 2
... the publication of several commentaries in the scientific journal ... embryos it is safe and proper to place in a uterus, ... faced by all patients anxiously caught between no pregnancies at all ... place it is often all too easy to think that the ...
... German . The Deutsche Forschungsgemeinschaft (DFG, German ... Research Units and two Humanities Centres for Advanced Studies. This ... its July meeting in Bonn. The aim of the research ... devote their time to current and urgent questions in their ...
... Reserve University School of Medicine has received a $2.1 million ... the National Institutes of Health (NIH), to expand basic research ... is an inherited disease that causes thick, sticky mucus to ... NIH grant was awarded to Mitchell Drumm, PhD, and Craig ...
Cached Biology News:IVF treatment and multiple births: Free-market patient rights versus government regulation 2IVF treatment and multiple births: Free-market patient rights versus government regulation 3From bone metastases to water supply 2From bone metastases to water supply 3From bone metastases to water supply 4From bone metastases to water supply 5From bone metastases to water supply 6CWRU receives $2.1 million NIH grant to expand cystic fibrosis research models 2
(Date:9/30/2014)... September 30, 2014 SoundConnect, ... collaboration company is dedicated to supporting business communication ... Julie Power, a carrier services ... collaboration solutions stays connected and productive at all ... increased movement of businesses to cloud communications services. ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... the forefront of diagnostics today, with imaging techniques ... scanning, and NMR (nuclear magnetic resonance) increasing steeply ... of image resolution and quality still limit these ... A solution is hyperpolarization, which involves injecting the ... by following the distribution and fate of specific ...
(Date:9/29/2014)... - Portage Biotech Inc. ("Portage" or "the Company") (OTC: PTGEF, ... its three Promissory Note holders, two of whom are ... in July 2014 for a total of $ 300,000 ... into 3,500,001 restricted common shares. Notes were repayable within ... and the coupon were convertible into common shares to ...
Breaking Biology Technology:SoundConnect Expands Carrier Services Division 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Portage announces conversion of its debt into equity 2Portage announces conversion of its debt into equity 3
... On Wednesday, October,22, 2008, Wyeth (NYSE: WYE ) ... Company will hold a one-hour conference call with,research analysts ... Interested,investors and others may listen to the call live ... may be accessed by visiting our website,at http://www.wyeth.com ...
... BOCA RATON, Fla., Sept. 8 NovaVision today ... at the prestigious AdvaMed,2008: The MedTech Conference ... DC., During the presentation, which falls in ... appointed chief executive officer of,NovaVision, will address the ...
... 8 Human Genome,Sciences, Inc. (Nasdaq: HGSI ) ... 2008 Small Cap Healthcare Conference will be webcast and,may ... http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO ), A member of Human Genome ... Wednesday, September 10, 2008 at 10:15 am Eastern,Time., ...
Cached Biology Technology:NovaVision CEO Named Presenter at the AdvaMed 2008 Conference 2
EML1 (K-16)...
Bovine Coronary Artery Smooth Muscle Cells (BCASMC) (>500,000 cells)...
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
... adapter allows the Thermo-Fast® ... AB-1000) PCR plates to ... ABI PRISM® 3700 capillary ... for information on the ...
Biology Products: