Navigation Links
UT Southwestern research reveals how cancer-driving enzyme works
Date:5/6/2011

DALLAS May 6, 2011 Cancer researchers at UT Southwestern Medical Center are helping unlock the cellular-level function of the telomerase enzyme, which is linked to the disease's growth.

Their latest findings, published today in Molecular Cell, demonstrate that telomerase repairs chromosomes in one of two ways depending on whether a cell is dividing normally or if the cell is under stress from enzyme inhibition and could lead to new or improved cancer-fighting therapies that promote inhibition of this enzyme.

"It's a significant advance in our understanding of how telomerase works," said Dr. Woodring Wright, professor of cell biology and senior author of the study. "Our goal is to identify new targets for inhibiting telomerase."

The number of times a cell divides is determined by telomeres, protective caps on the ends of chromosomes that indicate cell age. Every time a cell divides, the telomeres shorten. When telomeres shrink to a certain length, the cell either dies or stops dividing. In cancer cells, the enzyme telomerase keeps rebuilding the telomeres, so the cell never receives the cue to stop dividing.

Although telomerase was discovered in 1985, exactly how this enzyme repairs telomeres to enable cancer cells to divide and grow was largely unknown. Until now, researchers didn't know how many telomerase molecules went into action at the telomeres and under what conditions.

"It's a single molecule under normal cancer growth conditions, but if you shorten telomeres artificially by inhibiting telomerase, now it's more than one molecule acting on the ends of the telomeres," Dr. Wright said of the study's findings.

When acting as a single molecule at the telomeres, telomerase adds about 60 nucleotide molecules "in one fell swoop to the end of the chromosome," Dr. Wright said.

Researchers also discovered that structures in cells called Cajal bodies help process telomerase during chromosome
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Signaling path in brain may prevent that Im full message, UT Southwestern scientists discover
2. Team of scientists predicts continued death of forests in southwestern US due to climate change
3. UT Southwestern researchers uncover culprits in life-threatening clotting disorder
4. Alcohol consumers are becoming the norm, UT Southwestern analysis finds
5. UT Southwestern researchers find key step in bodys ability to make red blood cells
6. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
7. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
8. UT Southwestern researchers identify key molecular step to fighting off viruses
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. New brain nerve cells key to stress resilience, UT Southwestern researchers find
11. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... October 16, 2014 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... technologies including Wocket™, the Smart Wallet, at the 13 ... is a leading global conference on the intersection of ... Mark Anderson , founder and publisher of the ...
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... This release is also available in Chinese ... (September 28, 2010) -- The second law of thermodynamics is ... its implicit existential crunch. The tendency of a closed systems ... removed is a popular, if not depressing, "things fall apart" ...
... MT. ROYAL, NJ (September 28, 2010) "Migraine feels ... face," says author Andrew Levy in his interview on the ... of Our Heads". "It,s a metaphysical crisis." In the ... his personal experience with managing the pain of migraine, how ...
... (Sept. 28, 2010) -- A new book, RNA ... reviews our understanding of two RNA worlds: the primordial RNA ... and biocatalyst; and the contemporary RNA world, in which mRNA, ... operate. "[T]he plasticity of RNA stemming from ...
Cached Biology News:Tiny generators turn waste heat into power 2American Migraine Foundation launches new podcast series 2New book reviews ancient and modern worlds of RNA 2
(Date:10/20/2014)... -- GenVec, Inc. (NASDAQ: GNVC ) today announced the ... board of directors effective on October 24, 2014.   Dr. Horovitz ... its chairman from June 2006 to November 2013.  During his ... and Audit Committees of the board.  "We ... service to GenVec, and its stockholders," said Wayne T. ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... October 19, 2014 The Asian Automatic ... Asian with analysis and forecast of revenue. The Automatic ... to around $463.9 million by 2018, at a developing ... through the TOC of the Asian Automatic patient billing ... provided. This also provides a glimpse of the segmentation ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Pharmos Corporation,(Nasdaq: PARS ) announced today that ... from the Company., Mr. Rubino joined Pharmos ... acquisition and the subsequent integration of Vela,Pharmaceuticals completed ... has been focused on key business development priorities ...
... Synthetech, Inc. (OTC,Bulletin Board: NZYM) has earned ... outstanding accomplishments in environmental, health,safety and security ... by,the Synthetic Organic Chemical Manufacturers Association (SOCMA) ... awards are highly,regarded and demonstrate Synthetech,s level ...
... Dec. 18 January 1, 2008 will mark the,ritualistic day ... The New,Year also brings added pressure to smokers as January ... For those resolving to make 2008 the start of a ... Laser Therapy,provided by Achieve Laser, is quickly becoming a very ...
Cached Biology Technology:Pharmos Corporation Announces President & COO Alan L. Rubino to Leave Company 2Synthetech Earns National Recognition for Performance Improvement Program 2Synthetech Earns National Recognition for Performance Improvement Program 3Laser Therapy Gives Smokers Hope for Successful New Year's Resolution 2
... SYBR Safe DNA gel stain was developed ... than ethidium bromide for staining DNA in agarose ... only less mutagenic than ethidium bromide but SYBR ... of ethidium bromide. SYBR Safe stain comes as ...
... Service enables scientists who do not have access ... to have their biological samples tested for the ... easy as 1-2-3 Chose the analytes ... from the S&S antibody menu. Send your ...
... I nucleic acid gel stain is an ... bright fluorescence when bound to dsDNA and low ... dsDNA in gels using laser scanners or standard ... has also found uses in capillary electrophoresis, real-time ...
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic gel acid stain has also found ... bandshift assays. One mL stains 100 minigels. A ...
Biology Products: