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UT Southwestern research could lead to new treatments for IBD, viral infections
Date:10/19/2011

irus more efficient, Dr. Pfeiffer and colleagues incubated viruses in different warm environments to see how long they took to decay.

Virus incubated in salt water decayed over time, as expected. In contrast, virus incubated in any of several strains of bacteria became up to five times more infectious.

"Bacteria are literally activating the virus. There is nothing in that test tube that the virus can use for replication, so it must be increasing the viral infectivity," she said.

But the researchers wanted to delve deeper. They found that two different carbohydrates (polysaccharides) on the bacterial cell surface lipopolysaccharide (LPS) and peptidoglycan were able to spike poliovirus infectivity even in the absence of bacteria.


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Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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