Navigation Links
UT Southwestern research could lead to new treatments for IBD, viral infections
Date:10/19/2011

oper and her colleagues showed for the first time how the protein works to police the intestinal demilitarized zone, preventing the naturally occurring bacteria from invading the wall of the intestine, where they can cause problems such as IBD.

"If too many bacteria invade this demilitarized zone, you get ramped up production of the protein RegIIIγ and it pushes them back," Dr. Hooper said.

In people with IBD in which inflammation and the body's response to it can result in painful ulcers and bloody diarrhea the demilitarized zone is compromised and more bacteria come in contact with the intestinal lining, she explained.

Dr. Hooper's four-year study, which compared the intestinal health of mice that lacked the protein with that of normal mice, found that mice lacking the protein also lacked the protected space between the bacteria and the intestinal lining.

The researchers have patented RegIIIγ as a potential antibiotic therapeutic, though further study is needed to determine if the protein could be developed to help people with IBD or related diseases.

In her study, Dr. Pfeiffer found that mice lacking the normal intestinal bacteria had half the death rate from polio as mice with intact gut bacteria. The findings were the opposite of what the researchers had expected because, like most people, they had expected the body's intestinal bacteria to offer protection from viral diseases as they have been shown to protect against bacterial infection, she explained.

So Dr. Pfeiffer's research team conducted a series of experiments to validate and expand that finding, all of which backed up the original conclusion. For instance, they found that virus exposed to bacteria could attach to human cells better than virus that lacked bacterial exposure.

Poliovirus is a very wasteful entity, with only about one in 200 viral particles able to cause infection. To determine whether bacteria could make poliov
'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Waste from gut bacteria helps host control weight, UT Southwestern researchers report
2. RSV may hide in the lungs, lead to asthma, UT Southwestern researchers report
3. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
4. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
5. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
6. UT Southwestern scientist honored among best in Texas research
7. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
8. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
9. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
10. Two UT Southwestern researchers awarded Sloan fellowships
11. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... evolution experiment scientists from GEOMAR Helmholtz Centre for ... Sea Fisheries have demonstrated for the first time, ... the world,s oceans, Emiliania huxleyi , can ... temperatures. In their study, the researchers found no ... to these two aspects of climate change would ...
(Date:9/15/2014)... that the proteins in our cells cooperate with one ... tens of thousands of different proteins find the correct ... human body, brain and nervous system. A recent breakthrough ... busted down the door and provided a look at ... , Professor emeritus Jens Jrgen Led of the University ...
(Date:9/15/2014)... September 15, 2014: Globally, cardiovascular disease (CVD) claims 17 ... pressure take an additional 9.4 million. 1 New ... Fed Lipid Congress in Montpellier, France on September 15, ... a beneficial role. , At the Milk ... association between milk and risk for hypertension and CVD ...
Breaking Biology News(10 mins):Small algae with great potential 2Small algae with great potential 3Protein courtship revealed through chemist's lens 2Protein courtship revealed through chemist's lens 3Dairy consumption linked to lower blood pressure and cardiovascular disease risk 2
... recognition of her ongoing support of the nation,s human ... 2012 recipient of the National Space Biomedical Research Institute,s ... was honored today during the official opening of a ... Baylor College of Medicine,s Center for Space Medicine (CSM). ...
... Wildlife Conservation Society, the ARC Centre for Excellence ... more than 40 coral reefs in the Indian ... between local communities, conservation groups, and governmentsprovides one ... The finding is the outcome of the largest ...
... ColdQuanta Inc. of Boulder and the University of Colorado ... physics research developed by CU-Boulder and SRI International. The ... new form of matter created just above absolute zero. ... be used to dramatically increase the performance of devices ...
Cached Biology News:Space research institute honors Sen. Hutchison with Pioneer Award 21 solution to global overfishing found 21 solution to global overfishing found 3Ultracold matter technology from CU and SRI International licensed to Boulder's ColdQuanta 2
(Date:9/16/2014)... Norris, TN (PRWEB) September 16, 2014 ... several new initiatives to position themselves for ... capabilities for labeling and encoding, Pharma Packaging ... adding new hardware and software and new ... on current Good Manufacturing Practices (cGMP), Pharma ...
(Date:9/16/2014)... 2014 Convoy Therapeutics, Inc., a ... products to treat patients directly at the site ... SPACE™ Technology Platform announced today that John Muraski, ... at the White Hat Life Science Investor Conference™ ... Phoenix. In addition, interested individuals can meet ...
(Date:9/16/2014)... , Sept. 16, 2014  LABSCO, the leading ... products to hospitals, physician office laboratories and alternate ... October 1, 2014, it will serve as Siemens ... market segments and as a semi-exclusive sales distributor ... contiguous United States . LABSCO ...
(Date:9/16/2014)... , Sept. 16, 2014 /PRNewswire-iReach/ -- Researchers found ... test identifies patients with bone fragility fracture when ... million people worldwide are at risk of fracture ... standard bone strength test, the DEXA bone density ... Society for Bone and Mineral Research Annual Conference ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 3ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 2ActiveLife's BMSi Test Provides Hope for 160 Million with Undetectable Risk of Bone Fracture 3
... May 25, 2011 SuperNova Diagnostics®, Inc., a ... health applications, today announced it has been selected ... Startup Entrepreneurs (SVASE) annual Launch: Silicon Valley 2011 ... June 7, 2011 at 1:15 p.m. PDT.  The ...
... 25, 2011 Otonomy, Inc., a ... diseases and disorders of the inner and middle ... as the company,s chief operations officer.  Mr. Wroblewski ... areas of manufacturing, product supply chain management, packaging ...
... (NPL), in collaboration with Linkping University, Sweden, have shown ... easily identified in ambient conditions using Electrostatic Force Microscopy ... only applicable to the material that consists of one ... of any number of layers is possible, the thicker ...
Cached Biology Technology:SuperNova Diagnostics® Selected to Present at Launch: Silicon Valley 2011 2Otonomy Appoints Gerald Wroblewski as Chief Operations Officer 2Otonomy Appoints Gerald Wroblewski as Chief Operations Officer 3
... new Adept CE 4100 high pressure ... flow precision, with software drive compensation, reducing ... 0.001-10mL/min are selectable in 0.001mL steps. , ... inert and bio-compatible., Pumps may be programmed ...
... The CHEF-DR III variable angle system, 220-240 ... greater than 6 Mb DNA fragments by pulsed ... electrophoresis cell, power module, variable-speed pump, 14 x ... comb holder, 15-well, 1.5 mm thick comb, screened ...
... membrane and filter paper sandwiches are composed ... two sheets of thick filter paper that ... filter paper sandwich. These 7 x 8.5 ... immunoblotting fit Ready Gel-sized gels and are ...
... Antibiotic isolated fromStreptomyces griseolusthat inhibits ... transferase activity in eukaryote ribosomes. Reported ... of cells including promyelocytic leukemia cells, ... adenocarcinoma cells. Initiates intracellular signals and ...
Biology Products: