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UT Public Health researchers find link to severe Staph infections
Date:12/23/2008

in the disease process. LukS-PV given through the nose protected the mice against pneumonia, conversely if administered subcutaneously it protected against skin infections.

Brown said, "The [vaccination] route and infection routes correlated with each other i.e., intranasally-immunized mice were better protected against pneumonia than subcutaneously vaccinated mice and subcutaneously-vaccinated mice were better protected against a skin infection than against pneumonia. This in part may be related to the type of immune response generated at the skin compared to the lung."

In addition, Brown and colleagues have examined the anti-PVL antibody responses in pediatric patients diagnosed with Staph infections compared to antibody responses to other USA300 virulence factors. The study found patients who had Staph infections caused by PVL-positive strains had a dominant response to the LukS and LukF proteins.


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Contact: Jade Waddy
jade.waddy@uth.tmc.edu
713-500-3307
University of Texas Health Science Center at Houston
Source:Eurekalert

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