Navigation Links
UT Public Health researchers find link to severe Staph infections

Researchers at The University of Texas School of Public Health recently described studies that support the link between the severity of community-acquired antibiotic-resistant Staphylococcus aureus (CA MRSA) infections and the Panton Valentine leukocidin (PVL).

The Panton Valentine leukocidin is made up of two components - LukF-PV and LukS-PV - and is typically produced by community-acquired methicillin-resistant S. aureus (CA MRSA). In the United States this strain is the most common CA MRSA isolate and can cause severe skin infections, pneumonia, bloodstream infections and surgical wound infections.

This work has identified using animal models that the PVL leukotoxin can be used as a vaccine against infections caused by CA MRSA. Results from the research will be published in the December issue of Clinical Microbiology and Infection.

According to the Centers for Disease Control and Prevention, the antibiotic-resistant USA300 CA MRSA strain is typically acquired by persons through contact with the bacteria. This Staph strain is not typically associated with hospitalizations or medical procedures.

Eric Brown, Ph.D., assistant professor of infectious diseases at the UT School of Public Health and colleagues also tested the virulence of PVL in CA MRSA by using clinical strains of USA300 that did and did not contain the pore-forming toxin.

"The bacteria is not the same as it was several years ago. It has all of the weapons and toxins that other strains don't have, which makes it easier for this strain to survive efficiently inside of cells," Brown said.

"Immunity directed against LukS was more efficient in protecting mice against a USA300 infection compared to mice vaccinated with LukF-PV or alpha toxin," Brown said. His research found that LukS-PV was effective at protecting against certain types of infections reinforcing the importance of this virulence factor in the disease process. LukS-PV given through the nose protected the mice against pneumonia, conversely if administered subcutaneously it protected against skin infections.

Brown said, "The [vaccination] route and infection routes correlated with each other i.e., intranasally-immunized mice were better protected against pneumonia than subcutaneously vaccinated mice and subcutaneously-vaccinated mice were better protected against a skin infection than against pneumonia. This in part may be related to the type of immune response generated at the skin compared to the lung."

In addition, Brown and colleagues have examined the anti-PVL antibody responses in pediatric patients diagnosed with Staph infections compared to antibody responses to other USA300 virulence factors. The study found patients who had Staph infections caused by PVL-positive strains had a dominant response to the LukS and LukF proteins.


Contact: Jade Waddy
University of Texas Health Science Center at Houston

Related biology news :

1. International public-private partnership offers new paradigm for medicinal chemistry
2. VCU survey: US public supports genetic research, testing and government spending on research
3. New national survey says public reveres bison
4. 2008 Ullyot Public Affairs Lecture
5. Bridging public and private research on bioinformatics and proteomics
6. Indiana University research at American Public Health Association meeting
7. BIO-key(R) Announces Additional $245,000 in Third Quarter Public Safety Orders
8. Stevens strengthens Dominican Republics Early Warning System for Inundations
9. American Physical Society announces Physics, a new, free, online publication
10. FAS honors Mark D. Levine with 2008 Public Service Award
11. Healthy Minds Across America features 48 public forums on mental health research, Sept. 14
Post Your Comments:
(Date:11/17/2015)... PARIS , November 17, 2015 ... November 2015.   --> Paris from ... --> DERMALOG, the biometrics innovation leader, has invented the ... and fingerprints on the same scanning surface. Until now two ... fingerprints. Now one scanner can capture both on the same ...
(Date:11/17/2015)...  Vigilant Solutions announces today that Mr. Dick ... --> --> Mr. ... partnership at TPG Capital, one of the largest global ... in revenue.  He founded and led TPG,s Operating Group, ... from 1997 to 2013.  In his first role, he ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. ... human interface solutions, today announced expansion of its ... ™ touch controller and display driver integration ... of smartphones. These new TDDI products add to ... (HD resolution), TD4302 (WQHD resolution), and TD4322 (FHD ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... , ... November 30, 2015 ... ... today announced tighter software integration with MarkLogic, the Enterprise NoSQL database platform ... information to drive change. , Smartlogic’s Content Intelligence capabilities provide a robust ...
(Date:11/28/2015)... ... 28, 2015 , ... • Jeon Jin Bio Corp, a Korean Biotech venture ... , Bird Free, an oil-based, gel formula ... modalities including visual, smell, taste and touch, enabling safe, effective avian control without toxic ...
(Date:11/27/2015)... ... November 27, 2015 , ... Pittcon is pleased to announce ... offered in symposia, oral sessions, workshops, awards, and posters. The core of ... applications such as, but not limited to, biotechnology, biomedical, drug discovery, environmental, food ...
(Date:11/26/2015)... November 26, 2015 ... Accutest Research Laboratories, a leading ... Organization (CRO), has formed a strategic ... - Temple Health for joint work ... (Photo: ) , --> ...
Breaking Biology Technology: