Navigation Links
UT-Houston's Northrup and colleagues uncover genetic link to spina bifida
Date:12/18/2007

HOUSTON (Dec. 18, 2007)Researchers at The University of Texas Medical School at Houston have discovered an association between genes regulating glucose metabolism and spina bifida. The decade-long study looked at more than 1,500 DNA samples from parents and their children with that birth defect.

UT Medical School researchers tested variants in a dozen genes that take part in glucose metabolism to look for a link between genetic variation in affected children and spina bifida. Each affected childs parents were also studied, as well as DNA from unaffected control samples. The samples were gathered from study participants in Houston, Los Angeles and Toronto.

Published in the Jan. 2008 issue of the journal Reproductive Sciences, the study titled Genes in Glucose Metabolism and Association with Spina Bifida, found an association between variants in three glucose metabolism genes and spina bifida. Glucose metabolism is the way the body uses its major fuel, which is sugar.

We are trying to find out what causes this neural tube defect. It has been recognized through epidemiological studies for a number of years that there was a connection between high glucose levels, either due to maternal diabetes or obesity and having a child with spina bifida, said co-author Hope Northrup, M.D., professor and director of medical genetics in the Department of Pediatrics at the UT Medical School. Our goal is to identify variations in specific genes of glucose metabolism that are important in the process, thus enabling us to more specifically determine the underlying problem.

Spina bifida is the most common permanently disabling birth defect in the United States, according to the Spina Bifida Association. It happens when the spine of the baby fails to close during the first months of pregnancy. It occurs in seven out of 10,000 births in the United States. According to the Spina Bifida Association of Texas, a Hispanic woman is twice as likely
'/>"/>

Contact: Melissa McDonald
Melissa.E.McDonald@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston  
Source:Eurekalert

Page: 1 2

Related biology news :

1. St. Jude influenza survey uncovers key differences between bird flu and human flu
2. 454 Sequencing uncovers a genetic basis for different social behaviors in wasp
3. Joslin researchers uncover potential role of leptin in diabetes
4. Agent that triggers immune response in plants is uncovered
5. UD plant biologists uncover top wetland plants hidden weapon
6. Massive microRNA scan uncovers leads to treating muscle degeneration
7. Scientists uncover how hormones achieve their effects
8. New study uncovers secrets behind butterfly wing patterns
9. Hemoglobin uncovered
10. UVa Health System team uncovers genes role in type 1 diabetes
11. Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT-Houston's Northrup and colleagues uncover genetic link to spina bifida
(Date:7/25/2014)... N.Y., July 25, 2014 In the first broad-scale estimate ... Service scientists and collaborators calculated that trees are saving ... 670,000 incidences of acute respiratory symptoms. , While trees, ... of less than 1 percent, the impacts of that ... of the reduced air pollution at nearly $7 billion ...
(Date:7/25/2014)... Before the colonial era, 100,000s of people lived on ... cultures manipulated fire to control the availability of plants ... tribes continue to use fire to maintain desired habitat ... the U.S. Forest Service,s Pacific Southwest Station, will lead ... National Wildfire Refuge during the Ecological Society of America,s ...
(Date:7/25/2014)... the Terra satellite show the different areas that have been ... The burn scars show up as reddish-brown splotches of ... across the remote parts of Eastern Russia in the Sakha ... instrument, it is still possible to see the smoke ... noted below show the devastating number of fires that have ...
Breaking Biology News(10 mins):First national study finds trees saving lives, reducing respiratory problems 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3
... evolution is a current and intriguing topic that evolutionary ... and chitons in particular, chromosome studies are ... mostly with simple methods. Only 2,5% of about ... karyologically investigated, all of them in the same order ...
... A new strategic report, The Human Brain From ... has been published today by the European Science Foundation ... the population is affected by a disorder of the ... support to research in all areas of neuroscience. ...
... for Ultrasound in Medicine and Biology (SIUMB) have agreed to ... , starting in 2013 with Volume 16. Appearing quarterly, the ... SIUMB. It will be available exclusively in electronic format on ... The Journal of Ultrasound deals with significant advances ...
Cached Biology News:Pan-European organizations call for an advanced understanding of the human brain 2Springer will collaborate with the Italian Society for Ultrasound in Medicine and Biology 2
(Date:7/25/2014)... THOUSAND OAKS, Calif. , July 25, 2014 /PRNewswire/ ... its Board of Directors today declared a $0.61 per ... dividend will be paid on Sept. 5, 2014, to ... business on Aug. 14, 2014.  About ... biology for patients suffering from serious illnesses by discovering, ...
(Date:7/25/2014)... of bacteria live in each person,s digestive tract. Scientists ... and stave off harmful infections, but their role in ... shed light on the role of these bacteria, a ... Alm recently tracked fluctuations in the bacterial populations of ... described in the July 25 issue of the journal ...
(Date:7/25/2014)... from the University of Leicester has furthered our ... potential to create new materials using nanosized ,building ... in the prestigious academic journal Physical Review ... examine in rich detail the structure and internal ... acetylene molecule and a single helium atom. , ...
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... targeted industries and geographic markets. , ... Englewood, CO ... company, onTargetjobs Inc. (OTJ), has announced new solutions for ... focused industries and into specific, geographically localized markets. , , , ...
... 21 Jubilant Organosys Ltd,headquartered in Noida near ... Ltd., based in Bangalore, has developed a next ... the process of,high throughput screening, accelerating global drug ... US and Europe initially, allows scientists to capture,store, ...
... CryoLife, Inc. (NYSE: CRY ) , ... it received tissue from its 100,000th individual donor. ... Kansas-based organ and tissue procurement organization.Since 1984, through the ... the organ and tissue procurement organizations, CryoLife has been ...
Cached Biology Technology:onTargetjobs Offers Employers New Recruitment Solutions to Reach Local Career Candidates 2Jubilant Biosys Launches Legend NGSS(TM) Advanced Software Solution for High-Throughput Drug Molecule Screening 2CryoLife, Inc. Receives Tissue From 100,000th Donor, Marking Industry Milestone 2
Purified anti-human CD182 (CXCR2)...
Polyclonal Antibody to AGAP1 / Centaurin, gamma 2...
Mouse monoclonal [b/e4 (9.20)] to Cytochrome P450 2B1 + 2B2 ( Abpromise for all tested applications)....
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Biology Products: