Navigation Links
UT Dallas study: Initial success for new tinnitus treatment
Date:11/21/2013

UT Dallas researchers have demonstrated that treating tinnitus, or ringing in the ears, using vagus nerve stimulation-tone therapy is safe and brought significant improvement to some of the participants in a small clinical trial.

Drs. Sven Vanneste and Michael Kilgard of the School of Behavioral and Brain Sciences used a new method pairing vagus nerve stimulation (VNS) with auditory tones to alleviate the symptoms of chronic tinnitus. Their results were published on Nov. 20 in the journal Neuromodulation: Technology at the Neural Interface.

VNS is an FDA-approved method for treating various illnesses, including depression and epilepsy. It involves sending a mild electric pulse through the vagus nerve, which relays information about the state of the body to the brain.

"The primary goal of the study was to evaluate safety of VNS-tone therapy in tinnitus patients," Vanneste said. "VNS-tone therapy was expected to be safe because it requires less than 1 percent of the VNS approved by the FDA for the treatment of intractable epilepsy and depression. There were no significant adverse events in our study."

According to Vanneste, more than 12 million Americans have tinnitus severe enough to seek medical attention, of which 2 million are so disabled that they cannot function normally. He said there has been no consistently effective treatment.

The study, which took place in Antwerp, Belgium, involved implanting 10 tinnitus sufferers with a stimulation electrode directly on the vagus nerve. They received two and a half hours of daily treatment for 20 days. The participants had lived with tinnitus for at least a year prior to participating in the study, and showed no benefit from previous audiological, drug or neuromodulation treatments. Electrical pulses were generated from an external device for this study, but future work could involve using implanted generators eliminating the need for clinical visits.

Half of the participants demonstrated large decreases in their tinnitus symptoms, with three of them showing a 44-percent reduction in the impact of tinnitus on their daily lives. Four people demonstrated clinically meaningful reductions in the perceived loudness of their tinnitus by 26 decibels.

Five participants, all of whom were on medications for other problems, did not show significant changes. However, the four participants who benefited from the therapy were not using any medications. The report attributes drug interactions as blocking the effects of the VNS-tone therapy.

"In all, four of the ten patients showed relevant decreases on tinnitus questionaires and audiological measures," Vanneste said. "The observation that these improvements were stable for more than two months after the end of the one month therapy is encouraging."

Researchers at the University Hospital Antwerp, Belgium, and MicroTransponder Inc. also contributed to the study.

A larger study involving four different centers will soon begin in the United States.


'/>"/>

Contact: Ben Porter
ben.porter@utdallas.edu
972-883-2193
University of Texas at Dallas
Source:Eurekalert

Related biology news :

1. UT Dallas computer scientists create 3-D technique
2. UT Dallas researchers find early success in new treatment for stroke recovery
3. UT Dallas researchers pushing the boundaries of virtual reality
4. UT Dallas researchers awarded $4.3 million to create next-generation technologies
5. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
6. Study: Metformin for breast cancer less effective at higher glucose concentrations
7. Study: Death by moonlight? Not always
8. Study: Acidity can change cell membrane properties
9. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
10. Rutgers study: Worms may shed light on human ability to handle chronic stress
11. UT study: Chemical in antibacterial soaps may harm nursing babies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... LONDON , March 18, 2016 ... Established Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical ... & security companies in the border security market and ... and Europe has led ... your companies improved success. --> defence & ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/9/2016)... , March 9, 2016 This BCC ... future states of the RNA Sequencing (RNA Seq) market ... such as instruments, tools and reagents, data analysis, and ... various segments of the RNA-Sequencing market such as RNA-Sequencing ... Identify the main factors affecting each segment and forecast ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... MedDay, a biotechnology company focused on the treatment ... Moukheibir as Chairman of its Board of Directors. ... , who contributed to the rapid development of the Company ... started her career in strategy consulting and investment banking in ... .  She held C-Suite level roles in some of ...
(Date:4/26/2016)... ... April 26, 2016 , ... ... that Ardy Arianpour has joined the company as Chief Business Officer. Arianpour, a ... innovative genomic technologies to market, was most recently Chief Commercial Officer of Pathway ...
(Date:4/26/2016)... ... 2016 , ... Mr. Palmer created the RPO business for Ceridian and lead ... managed services contract in the U.S. intelligence community with The SI (a Lockheed Martin ... Younger, founder of Accolo. “We are growing and his experience guiding our expansion ...
(Date:4/26/2016)... Washington (PRWEB) , ... April 26, 2016 , ... ... today announced receipt of a significant operating grant from 1Plus12 Corporation. The grant ... to commence pre-proposal activities as outlined on the organization's website http://www.ivsci.org ...
Breaking Biology Technology: