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UT Arlington study links BPA and breast cancer tumor growth
Date:3/6/2014

AIR involved in tumor genesis in addition to tumor growth?

BPA has been widely used in plastics, such as food storage containers, the lining of canned goods and, until recently, baby bottles. It belongs to a class of endocrine disrupting chemicals, or EDCs, which have been shown to mimic natural hormones. These endocrine disruptors interfere with hormone regulation and proper function of human cells, glands and tissue. Previous studies have linked BPA to problems with reproductive development, early puberty, obesity and cancers.

Under normal circumstances, estrogen regulates HOTAIR, turning its expression on and off through interaction with molecules called estrogen-receptors, or ERs, and estrogen receptor-coregulators, or ER-coregulators. The new study found that BPA disrupts the normal function of the ERs and the ER-coregulators when estrogen was present and when it wasn't, potentially implicating it in tumor growth in a variety of cancers.

"Research work is at its best when results can shed light on issues of public concern. Dr. Mandal and his team are using their expertise to do just that. Their findings continue to advance what we know about how the chemicals in our environment could be affecting us in unseen ways," said Pamela Jansma, dean of the UT Arlington College of Science.

Researchers saw similar results when they exposed HOTAIR to a synthetic estrogen called diethylstilbestrol (DES). DES has been shown to increase risks of breast cancer and other health problems in women who used it and their daughters. It was formerly used as a hormone replacement and as an attempt to prevent pregnancy complications.


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Contact: Traci Peterson
tpeterso@uta.edu
817-521-5494
University of Texas at Arlington
Source:Eurekalert  

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