Navigation Links
UT Arlington research may unlock enzyme's role in disease
Date:1/2/2014

A UT Arlington chemist doing National Science Foundation-funded research on enzymes that regulate human biology has uncovered characteristics that could be used to identify predisposition to conditions such as heart disease, diabetic ulcers and some types of cancer.

Brad Pierce, an assistant professor of chemistry/biochemistry at The University of Texas at Arlington, recently led a team that examined an oxygen utilizing iron enzyme called cysteine dioxygenase or CDO, which is found in high levels within heart, liver, and brain tissues. Enzymes are proteins that act as catalysts to enable metabolic functions, but under some circumstances these oxygen-dependent enzymes can also produce highly toxic side products called reactive oxygen species or ROS.

For the first time, Pierce's team found that mutations outside the CDO active site environment or "outer coordination sphere" have a profound influence on the release of ROS. Excess ROS has been linked to numerous age-onset human disease states.

"Most research in the past has focused on the active site inner coordination sphere of these enzymes, where the metal molecule is located," said Pierce. "What we're finding is that it's really the second sphere that regulates the efficiency of the enzyme. In essence, these interactions hold everything together during catalysis. When this process breaks down, the enzyme ends up spitting out high levels of ROS and increasing the likelihood of disease."

The study was published in December by the American Chemical Society journal Biochemistry. Pierce is corresponding author on the paper, with UT Arlington students Wei Li, Michael D. Pecore and Joshua K. Crowell as co-authors. Co-author Elizabeth J. Blaesi is a graduate research assistant at the University of Wisconsin.

Pierce believes the findings from the CDO enzyme could be applied to other oxygen-dependent enzymes, which make up about 20 percent of the enzymes in the hu
'/>"/>

Contact: Traci Peterson
tpeterso@uta.edu
817-521-5494
University of Texas at Arlington
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UT Arlingtons Nguyen named American Heart Association fellow
2. NSF awards to UT Arlington researchers will fuel sustainable solutions
3. 9 UT Arlington educators honored for teaching excellence
4. UT Arlington engineer to design prototype that predicts flash flooding
5. UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline
6. UT Arlington engineer to search for bad algal blooms
7. UT Arlington bioengineer to use hybrid imaging system to see deep tissue
8. UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
9. National Academy of Inventors names four UT Arlington professors as charter fellows
10. UT Arlington physics team demonstrates new power generation technique
11. National herpetology society honors UT Arlington professor for discoveries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UT Arlington research may unlock enzyme's role in disease
(Date:7/13/2014)... is available in French . ... An international research project, led by the Research Institute ... reports that a new oral medication is showing significant ... amaurosis (LCA). Until now, this inherited retinal disease that ... blindness, has remained untreatable. The study is published today ...
(Date:7/13/2014)... New research raises the prospect of more effective ... muscle occurring in about half of all cancer patients, ... Dana-Farber Cancer Institute. , Many strategies have been tried ... that patients can,t endure potentially life-saving treatments, but none ... July 13 advanced online edition of Nature , ...
(Date:7/11/2014)... the Wildlife Conservation Society shows that no-take zones ... species such as lobster, conch, and fish recover ... reef areas. , The reporttitled "Review of the ... research literature from no-take areas around the world. ... a recognized expert in marine protected areas and ...
Breaking Biology News(10 mins):MUHC researcher unveils novel treatment for a form of childhood blindness 2Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3Belize's lobster, conch, and fish populations rebuild in no-take zones 2
... School of Medicine has revealed key features in ... and other extreme environments. The researchers, funded by ... environment of Antarctica. They found subtle but significant ... and Haloarchaea, organisms that can tolerate severe conditions ...
... that pumpkins and cucumbers can be traced back to India. ... of Cucurbitaceae evolution and diversity, a new checklist of the ... that family. The study was published in the open access ... components of a healthy daily diet, not just in India ...
... of continuing evolution in the college textbook market, an ... leader (NYSE:JWa, JWb), and Rice University-based OpenStax College, a ... partnership calls for Wiley to deliver content from OpenStax ... online learning, practice and assessment resources that are ...
Cached Biology News:University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars 2A new checklist confirms Indian origins of pumpkins and cucumbers 2Unlikely partners create innovative product for college biology 2
(Date:7/10/2014)... 2014 Senior supply chain management executives ... addressed the challenges of “Reducing Cost, Lead Time, & ... strategic sourcing. Describing the partnership of the Bio Supply ... Management Institute ( SCMI) of the University of ... at the Kroc Institute of Peace and Justice in ...
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
(Date:7/10/2014)... in the journal PNAS (Proceedings of the National ... day and sleep deprivation have a significant effect on ... at the best time of day to test for ... administering medicines effectively. , Researchers from the University of ... the links between sleep deprivation, body clock disruption and ...
(Date:7/10/2014)... theatergoers have shelled out for crude 3-D glasses, ... viewing experience. These basic devices, used to trick ... may soon be rendered obsolete with the introduction ... University researchers. , TAU doctoral students Yuval Yifat, ... efficient holography based on nanoantennas that could be ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... a simple and convenient technique that combines nanoscale ... elusive goal. With current analytical instruments, spatial resolution ... preparation too complex or sample size too large ... the University of Illinois have demonstrated a method ...
... LAKES, N.J., March 27 BD (Becton,Dickinson and ... medical technology,company, and Direct Relief International, a humanitarian ... volunteer,initiative to strengthen healthcare in Ghana. A team ... Ghana for three weeks and work side-by-side,with Direct ...
... (Nasdaq: GNTA ) announced that the NASDAQ ... an extension of,time to achieve full compliance with ... decision, the listing of the,Company,s common stock will ... NASDAQ Capital Market, effective with the open of ...
Cached Biology Technology:Femtogram-level chemical measurements now possible, U. of I. team reports 2BD and Direct Relief International Launch Second Volunteer Service Trip to Improve Healthcare in Ghana 2BD and Direct Relief International Launch Second Volunteer Service Trip to Improve Healthcare in Ghana 3Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 2Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 3
Recombinant Rhesus Macaque IFN-alpha...
... 500 g protein in 200 l SDS-PAGE ... cell lysate; Abelson transformed macrophage cells, ... positive control, should be stored ... be minimized, sample vial should ...
The epitope is specific for TASK and is not present in any other known proteins tested so far.,SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues iden...
Anti-Mouse MIP-1g, Biotin (Polyclonal) (rabbit IgG)...
Biology Products: