Navigation Links
UT Arlington bioengineer to create new nanoparticle system to shore up arterial walls
Date:2/4/2014

A UT Arlington bioengineer has received a four-year, $1.4 million National Institutes of Health grant to create a nanoparticle system to shore up arterial walls following angioplasty and stenting procedures to treat coronary arterial disease.

Kytai Nguyen, a UT Arlington associate professor of bioengineering, said the research looks to improve an established procedure like angioplasty, which opens arteries and blood vessels that are blocked.

"We have discovered a way to use nanoparticles to help the arteries heal themselves more effectively following one of the most common surgical procedures," said Nguyen, who joined UT Arlington in 2005. "This process promises to reduce complications that can occur in the arteries following surgery and may extend opportunities for patients to live longer, healthier lives."

The Centers for Disease Control and Prevention reported that nearly 1 million people in the United States have angioplasty or stent procedures done annually.

Khosrow Behbehani, dean of the College of Engineering, said Dr. Nguyen is specializing in developing innovative techniques for drug delivery which critical to advancing health care.

"Earning a National Institutes of Health grant puts Dr. Nguyen in very exclusive company," Behbehani said. The NIH reported that only 16.8 percent of its nearly 50,000 applications in 2013 were awarded grants. "Receiving this grant reflects the cutting-edge research that Dr. Nguyen is conducting. Her investigation will help improve the efficacy of stents in treating cardiovascular anomalies."

Following the angioplasty or stent, surgeons would insert the nanoparticles at the affected site, and the nanoparticles would attach themselves to the arterial wall. The nanoparticles would be programmed to recruit stem cells, which would regenerate the arterial wall's weakened cells naturally, Nguyen said.

Once cell regeneration is well under way, the nanoparticles will dissipate, she said.

The process addresses concerns that arise when a person's underlying smooth muscle cells migrate to the weakened arterial walls and the blood cells attack this damaged site.

"Your body naturally will send smooth muscle cells to the weakened walls," Nguyen said. "That creates a whole host of problems the body doesn't need. It could cause re-narrowing of an artery, leading to a heart attack."

Liping Tang, bioengineering professor and interim chair of the Bioengineering Department, said Nguyen's work makes the surgery safer for the patient.

"Using nanotechnology to solve the problem before it even occurs is ingenious," Tang said.

Nguyen previously received an American Heart Association grant to study how physical and biological factors influence the proliferation of vascular smooth muscle cells, a condition that can lead to heart disease. She recently received another American Heart Association grant to develop advanced particle scaffolds for treatments of peripheral arterial disease.

She also has teamed with a UT Southwestern colleague to develop a nanoparticle drug delivery system that will help stimulate lung growth and function after partial lung removal or destructive lung disease.


'/>"/>

Contact: Herb Booth
hbooth@uta.edu
817-272-7075
University of Texas at Arlington
Source:Eurekalert

Related biology news :

1. UT Arlington research may unlock enzymes role in disease
2. UT Arlingtons Nguyen named American Heart Association fellow
3. NSF awards to UT Arlington researchers will fuel sustainable solutions
4. 9 UT Arlington educators honored for teaching excellence
5. UT Arlington engineer to design prototype that predicts flash flooding
6. UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline
7. UT Arlington engineer to search for bad algal blooms
8. UT Arlington bioengineer to use hybrid imaging system to see deep tissue
9. UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
10. National Academy of Inventors names four UT Arlington professors as charter fellows
11. UT Arlington physics team demonstrates new power generation technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System ... standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography ...
Breaking Biology Technology: