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USU scientists report major advance in human antibody therapy against deadly Nipah virus
Date:10/30/2009

ompassionate attempt to save a human life, an available low dose of m102.4 was administered to an individual with advanced encephalitic disease. Although there were no adverse side effects, the patient did not improve as the irreversible damage by the virus had already been done. Like other antimicrobials, the clinical success of this antibody will depend on dose and time of administration. As Hendra and Nipah viruses cause severe disease in humans, a successful application of this antibody as a post-exposure therapy will likely require early intervention.

"In order to make clinical use of this therapeutic antibody against Hendra or Nipah virus, larger amounts will need to be prepared under proper manufacturing guidelines, carefully evaluated again in animal models and safety tested for human use" said Dr. Broder.

Dr. Bossart noted, "We hope this demonstration of anti-viral activity will foster some immediate activities to facilitate further development for future use in humans."

"There are currently no licensed and approved vaccines or therapeutics for prevention and treatment of disease caused by these viruses for humans or livestock," said Dr. Broder. "This fully-human monoclonal antibody is the first antiviral agent against the Nipah and Hendra viruses that has a genuine potential for human therapeutic use."

"The generation of these antibodies as therapeutics could help control outbreaks in geographical regions susceptible to henipaviruses, and could turn information from a deadly pathogen into a benefit for mankind," said Dr. Dimitrov.


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Contact: JoAnn Sperber
jsperber@hjf.org
301-294-1234
Henry M. Jackson Foundation for the Advancement of Military Medicine
Source:Eurekalert

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