Navigation Links
USF researchers identify gene mutation linked to old age hearing loss
Date:10/25/2012

TAMPA, Fla. (Oct. 25, 2012) - University of South Florida researchers have identified a genetic biomarker for age-related hearing loss, a major breakthrough in understanding and preventing a condition of aging that affects 30 million Americans and greatly diminishes their quality of life.

In a nine-year study that was a collaboration between USF's Global Center for Hearing & Speech Research and the National Technical Institute for the Deaf at the Rochester Institute of Technology, researchers were able to identify the first genetic biomarker for presbycusis. The genetic mutation carried by those who ultimately suffer from age-related hearing loss is linked to speech processing abilities in older people.

Their findings are published in the journal Hearing Research. The study was authored by USF College of Engineering professors Robert Frisina Jr. and Robert Frisina Sr., the founders of the Global Center for Hearing & Speech Research, and David Eddins, a USF associate professor of communication sciences and disorders and chemical and biological engineering.

In collaboration with the House Ear Institute in Los Angeles, the researchers discovered a gene that produces a key protein in the inner ear the cochlea called glutamate receptor metabotropic 7 (GRM7). The GRM7 protein is intimately involved in converting sound into the code of the nervous system, in the cochlea, which is then sent to the parts of the brain used for hearing and speech processing.

Now having identified the gene, the researchers said people can be tested and takes steps earlier in life such as avoiding loud noises, wearing ear protection and avoiding certain medicines known to damage hearing to protect their hearing.

"This gene is the first genetic biomarker for human age related hearing loss, meaning if you had certain configurations of this gene you would know that you are probably going to lose your hearing faster than someone who might have another configuration," said Robert Frisina Jr.

The Frisinas launched their study of genetics' role in hearing loss nine years ago in hopes of identifying the cause of one of the most common forms of permanent hearing loss. Clinically, age-related hearing loss has been defined as a progressive loss of sensitivity to sound, starting at the high frequencies, inability to understand speech, the lengthening of the minimum discernable temporal gap in sounds, and a decrease in the ability to filter out background noise. Researchers now know the causes of presbycusis are likely a combination of multiple environmental and genetic factors.

"Age-related hearing loss is a very prevalent problem in our society. It costs billions of dollars every year to manage and deal with it. It's right up there with heart disease and arthritis as far as being one of the top three chronic medical conditions of the aged," said Robert Frisina Jr.

DNA analyses were conducted and completed at the University of Rochester Medical School and the Rochester Institute of Technology.

The study involved 687 people who underwent three hours of extensive examination of their hearing capabilities, including genetic analyses and testing of speech processing.

Interestingly, the gene mutation played out differently in women than in men, the researchers found. While the variation had a negative impact for men, it did the opposite for women, who actually had better than average hearing in their elder years. That discovery supports a 2006 finding by the Frisina research group that the hormone aldosterone plays a role in hearing capabilities.
'/>"/>

Contact: Vickie Chachere
vchachere@usf.edu
813-974-6251
University of South Florida (USF Health)
Source:Eurekalert

Related biology news :

1. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
2. Danish researchers release ground-breaking knowledge about calcium pumps in cells
3. CU-Boulder researchers uncover new target for cancer research
4. Columbia researchers report novel approach for single molecule electronic DNA sequencing
5. Researchers develop new stamping process to pattern biomolecules at high resolution
6. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
7. RUB researchers clarify catalysis mechanism of cell growth protein Ras
8. Researchers find our inner reptile hearts
9. Researchers develop rapid method to measure carbon footprints
10. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
11. Researchers use banker plants to help battle whitefly pests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... -- Michael Johnson, co-founder of Visikol Inc. a company originally funded with ... to the elite "Forbes 30 Under 30" list in the Science ... 20 fields nationwide to be recognized as a leader in business ... ... a PhD candidate at Rutgers University. Visikol ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
(Date:12/20/2016)... Dec, 20, 2016   Valencell , the ... and STMicroelectronics (NYSE: STM), a global semiconductor ... applications, announced today the launch of a new, ... wearables that includes ST,s compact SensorTile ... biometric sensor system. Together, SensorTile and Benchmark ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... HACKENSACK, N.J. , Jan. 18, 2017   ... leading the fight to end Duchenne muscular dystrophy ... awarded to the New Jersey Institute of Technology (NJIT) ... ongoing exploration of robotic technology to assist ... study to incorporate NJIT,s technology – an embedded computer, ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... more and more E&L expertise. Within Albany Molecular Research, Inc. (AMRI), the scientific ... the past year and is planned for further growth in 2017. Extractable & ...
(Date:1/18/2017)... ... January 18, 2017 , ... Researchers from a new study are stating that ... enough after prostate cancer treatment, this indicates there is still remaining prostate cancer cells that ... “ The PSA test has always been an indicator of whether a man’s prostate cancer ...
(Date:1/18/2017)... ... January 18, 2017 , ... uBiome, the leading microbial ... its Science Editor, Dr. Elisabeth Bik, in the December 2016 issue of the ... uBiome in October 2016 from her previous position at Stanford University School of ...
Breaking Biology Technology: