Navigation Links
USF researchers identify gene mutation linked to old age hearing loss
Date:10/25/2012

TAMPA, Fla. (Oct. 25, 2012) - University of South Florida researchers have identified a genetic biomarker for age-related hearing loss, a major breakthrough in understanding and preventing a condition of aging that affects 30 million Americans and greatly diminishes their quality of life.

In a nine-year study that was a collaboration between USF's Global Center for Hearing & Speech Research and the National Technical Institute for the Deaf at the Rochester Institute of Technology, researchers were able to identify the first genetic biomarker for presbycusis. The genetic mutation carried by those who ultimately suffer from age-related hearing loss is linked to speech processing abilities in older people.

Their findings are published in the journal Hearing Research. The study was authored by USF College of Engineering professors Robert Frisina Jr. and Robert Frisina Sr., the founders of the Global Center for Hearing & Speech Research, and David Eddins, a USF associate professor of communication sciences and disorders and chemical and biological engineering.

In collaboration with the House Ear Institute in Los Angeles, the researchers discovered a gene that produces a key protein in the inner ear the cochlea called glutamate receptor metabotropic 7 (GRM7). The GRM7 protein is intimately involved in converting sound into the code of the nervous system, in the cochlea, which is then sent to the parts of the brain used for hearing and speech processing.

Now having identified the gene, the researchers said people can be tested and takes steps earlier in life such as avoiding loud noises, wearing ear protection and avoiding certain medicines known to damage hearing to protect their hearing.

"This gene is the first genetic biomarker for human age related hearing loss, meaning if you had certain configurations of this gene you would know that you are probably going to lose your hearing faster than someone who might have another configuration," said Robert Frisina Jr.

The Frisinas launched their study of genetics' role in hearing loss nine years ago in hopes of identifying the cause of one of the most common forms of permanent hearing loss. Clinically, age-related hearing loss has been defined as a progressive loss of sensitivity to sound, starting at the high frequencies, inability to understand speech, the lengthening of the minimum discernable temporal gap in sounds, and a decrease in the ability to filter out background noise. Researchers now know the causes of presbycusis are likely a combination of multiple environmental and genetic factors.

"Age-related hearing loss is a very prevalent problem in our society. It costs billions of dollars every year to manage and deal with it. It's right up there with heart disease and arthritis as far as being one of the top three chronic medical conditions of the aged," said Robert Frisina Jr.

DNA analyses were conducted and completed at the University of Rochester Medical School and the Rochester Institute of Technology.

The study involved 687 people who underwent three hours of extensive examination of their hearing capabilities, including genetic analyses and testing of speech processing.

Interestingly, the gene mutation played out differently in women than in men, the researchers found. While the variation had a negative impact for men, it did the opposite for women, who actually had better than average hearing in their elder years. That discovery supports a 2006 finding by the Frisina research group that the hormone aldosterone plays a role in hearing capabilities.
'/>"/>

Contact: Vickie Chachere
vchachere@usf.edu
813-974-6251
University of South Florida (USF Health)
Source:Eurekalert

Related biology news :

1. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
2. Danish researchers release ground-breaking knowledge about calcium pumps in cells
3. CU-Boulder researchers uncover new target for cancer research
4. Columbia researchers report novel approach for single molecule electronic DNA sequencing
5. Researchers develop new stamping process to pattern biomolecules at high resolution
6. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
7. RUB researchers clarify catalysis mechanism of cell growth protein Ras
8. Researchers find our inner reptile hearts
9. Researchers develop rapid method to measure carbon footprints
10. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
11. Researchers use banker plants to help battle whitefly pests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/29/2016)... RATON, Florida , March 29, 2016 ... or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are ... DNA in ink used in a variety of writing ... theft. Buyers of originally created collectibles from athletes on ... through forensic analysis of the DNA. ...
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... , May 3, 2016  Dr. Thomas P. ... in The Woodlands, Texas , now ... percent of treated fat cells in just 25-minutes, leaving ... to 90 percent of Americans report feeling bothered by ... fat reduction procedures are a growing industry. This innovative ...
(Date:5/3/2016)... ... 03, 2016 , ... Nashville Fertility Center has joined a ... reproductive endocrinologists, including Dr. George Hill at Nashville Fertility Center, created ... build families. , Ovation Fertility is a nationwide network of leading fertility centers ...
(Date:5/2/2016)... Willoughby, Ohio (PRWEB) , ... May 02, 2016 ... ... website. Designed with its clients in mind, the fresh look and added functionality ... capabilities. , “Recent years have seen a dynamic shift in agriculture – from ...
(Date:5/2/2016)... PA (PRWEB) , ... May 02, 2016 , ... ... proud to report on the pre-launch success of their revolutionary, veterinarian-designed product for ... cats to stalk, trap, and play with their food the way nature intended. ...
Breaking Biology Technology: