Navigation Links
USF receives NIH grant to study implications of maternal infection as cause of autism
Date:9/14/2010

Tampa, Fla. (Sept. 15, 2010) University of South Florida (USF) neuroscientists have been awarded a $400,000 federal grant to study ways of protecting the developing fetal brain from the damaging effects of maternal infections, a suspected cause for certain types of autism.

The two-year grant from the National Institute of Mental Health was awarded to Jun Tan, MD, PhD, the Silver Chair in USF Health Developmental Neurobiology and professor of psychiatry at the Silver Child Development Center, USF Department of Psychiatry.

Recent USF studies have uncovered a natural citrus molecule, luteolin, and a related compound, diosmin, which may protect the developing fetal brain from the harmful results of maternal infections, including inflammation that can disrupt brain development. Dr. Tan, the new grant's principal investigator, and his team found when either luteolin or diosmin were given to pregnant mice, the detrimental effects of maternal infection on their offspring could be reduced.

"These agents appear to block the activation of the mother's immune system," said Dr. Tan. "With this NIH grant, we will be able to further examine whether the over-activation of a signaling pathway could be responsible for the structural changes in the brains of offspring. We are going to test diosmin's potential to block autism-like brain changes in the offspring."

These studies could lay the foundation for using diosmin and related compounds, such as luteolin, as a preventative treatment for mothers at high risk of certain infections, Dr. Tan said. "Much like folate is currently given to pregnant mothers in prenatal vitamins to avoid neural tube defects in their children, these compounds could potentially be used to prevent maternal infections from causing harmful types of brain inflammation associated with autism in children."


'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-3154
University of South Florida (USF Health)
Source:Eurekalert

Page: 1

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... 2016 , ... Morris Midwest ( http://www.morrismidwest.com ), a division ... its Maple Grove, Minnesota technical center, May 11-12. The event will feature ... 20 leading suppliers of tooling, accessories, software and other related technology will participate ...
(Date:4/27/2016)... ... ... Shimadzu Scientific Instruments (SSI) will be showcasing a broad ... Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for potency, moisture, ... booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC testing, peak ...
(Date:4/27/2016)... York, NY (PRWEB) , ... April 27, 2016 ... ... realizing it. Touch screen mobile devices with fingerprint recognition for secure access, ... libraries are only a few ways consumers are interacting with biometrics technology today. ...
(Date:4/27/2016)... RESEARCH TRIANGLE PARK, N.C. , April ... UTHR ) announced today that Martine Rothblatt , ... will provide an overview and update on the company,s ... Health Care Conference. The presentation will take ... Eastern Time, and can be accessed via a live ...
Breaking Biology Technology: