Navigation Links
USF receives NIH grant to study implications of maternal infection as cause of autism
Date:9/14/2010

Tampa, Fla. (Sept. 15, 2010) University of South Florida (USF) neuroscientists have been awarded a $400,000 federal grant to study ways of protecting the developing fetal brain from the damaging effects of maternal infections, a suspected cause for certain types of autism.

The two-year grant from the National Institute of Mental Health was awarded to Jun Tan, MD, PhD, the Silver Chair in USF Health Developmental Neurobiology and professor of psychiatry at the Silver Child Development Center, USF Department of Psychiatry.

Recent USF studies have uncovered a natural citrus molecule, luteolin, and a related compound, diosmin, which may protect the developing fetal brain from the harmful results of maternal infections, including inflammation that can disrupt brain development. Dr. Tan, the new grant's principal investigator, and his team found when either luteolin or diosmin were given to pregnant mice, the detrimental effects of maternal infection on their offspring could be reduced.

"These agents appear to block the activation of the mother's immune system," said Dr. Tan. "With this NIH grant, we will be able to further examine whether the over-activation of a signaling pathway could be responsible for the structural changes in the brains of offspring. We are going to test diosmin's potential to block autism-like brain changes in the offspring."

These studies could lay the foundation for using diosmin and related compounds, such as luteolin, as a preventative treatment for mothers at high risk of certain infections, Dr. Tan said. "Much like folate is currently given to pregnant mothers in prenatal vitamins to avoid neural tube defects in their children, these compounds could potentially be used to prevent maternal infections from causing harmful types of brain inflammation associated with autism in children."


'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-3154
University of South Florida (USF Health)
Source:Eurekalert

Page: 1

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call it the “hairy ... a depiction of a system of linkages and connections so complex and dense ... of computer science at Worcester Polytechnic Institute (WPI) and director of the university’s ...
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer and recently formed ... entered into a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The ... gene editing across all applications. , Under the terms of the agreement, Pioneer ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... genomics analysis platform specifically designed for life science researchers to analyze and ... researcher Rosalind Franklin, who made a major contribution to the discovery of ...
Breaking Biology Technology: