Navigation Links
USC scientists uncover mechanism by which chronic stress causes brain disease
Date:6/29/2011

Chronic stress has long been linked with neurodegeneration. Scientists at USC now think they may know why.

The study, which has tremendous implications for understanding and treating Alzheimer's disease, was published in the June issue of The FASEB Journal (the Journal of the Federation of American Societies for Experimental Biology).

Corresponding author Kelvin J. A. Davies, the James E. Birren Chair at the USC Davis School of Gerontology, and Professor of Molecular & Computational Biology in the USC Dornsife College, examined the brains of rats that had experienced psychological stresses and found high levels of the RCAN1 gene. Davies and his colleagues suggest that chronic stress physical or mental causes overexpression of RCAN1, in turn leading to neurodegenerative disease.

Think of a gene as a pattern or mold that generates specific proteins. For example, if 200 RCAN1 proteins are built where only 100 were needed, scientists would describe this as "overexpression" of the RCAN1 gene.

In a healthy person, the RCAN1 gene helps cells cope with stress. Overproduction, however, can eventually damage neurons, preventing the brain's signals from traveling and causing disease.

Chronic overproduction of RCAN1 causes hyper-phosphorylation of tau proteins in the brain.

Tau proteins stabilize microtubules, which are like the scaffolding used to build the brain's neurons. Previous research has shown that when the tau protein binds too much phosphate a process called hyperphosphorylation it forms snarls that prevent the brain's signals from effectively traveling.

"One can imagine that it becomes sticky and makes tangled scaffolding," Davies said.

These neurofibrillary tangles eventually choke the life out of neurons, killing off brain function a tiny piece at a time in what is outwardly recognized as degenerative brain disease.

Currently, there are two competing theorie
'/>"/>

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCLA stem cell scientists discover new airway stem cell
2. Johns Hopkins scientists expose cancer cells universal dark matter
3. Lithuanian scientists clean up at 2011 EUREKA Innovation Award
4. Scientists a step closer to understanding natural antifreeze molecules
5. Scientists uncover an unhealthy herds hypothesis
6. Qld fruit fly scientists in race against time
7. UC Riverside neuroscientists discovery could bring relief to epilepsy sufferers
8. Scientists breakthrough attracts new funding for high blood pressure research
9. Scientists develop a fatty kryptonite to defeat multidrug-resistant Super bugs
10. Scientists learn how horseweed shrugs off herbicide
11. Scientists pitch in to help keep salad mixes safe to eat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical ... building for its School of Medicine. Funding for this ... capital campaign that will be publicly launched next summer. ... located in the former 60 series R.J. Reynolds Tobacco ... Quarter. Construction will begin immediately with plans to be ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a leader ... million in Series A1 funding led by UK-based Eurovestech. ... participated in the investment round. "We are ... community adopts next-generation sequencing and seeks new approaches for ... Reid Robison , MD MBA, and CEO of Tute ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... the University of Calgary have created a new, interactive tool ... LINDSAY, named after Dr. Lindsay Kimmett, a bright, promising medical ... human that uses a variety of touch interfaces to help ... real gap between textbook anatomy and what students see in ...
... seeds produced by many tropical trees were probably once ingested ... dispersed the seeds over large distances. But gomphotheres were probably ... aren,t large-seeded plants also extinct? A new Smithsonian report to ... of the National Academy of Sciences during the week ...
... pathway that Cannabis sativa uses to create bioactive compounds ... marijuana varieties to produce pharmaceuticals or cannabinoid-free industrial hemp. ... edition of the Proceedings of the National Academy ... professor of biology Jon Page explains that the pathway ...
Cached Biology News:LINDSAY: The future of medical education 2Have thieving rodents saved tropical trees? 2U of S researchers discover cannabis 'pharma factory' 2
(Date:12/19/2014)... , Dec. 19, 2014 Naurex Inc., a ... drugs for diseases of the central nervous system, today ... chief executive officer, will present at the 33 rd ... will take place at 3:00 p.m. PST on Tuesday, ... San Francisco, Calif. ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... Reports from CDC show approximately ... one or more chronic health conditions - including cardiovascular ... some of these diseases, but may not eliminate the ... While implanted nerve stimulation devices today offer relief, they ... can induce side effects. , To eliminate the ...
Breaking Biology Technology:Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2
... 11 LeMaitre,Vascular, Inc. (Nasdaq: LMAT ), which ... treatment of peripheral vascular,disease, is scheduled to participate in ... Tuesday, March 18, 2008, in Boston., George W. ... President, will provide an update on the company at ...
... SOUTH SAN FRANCISCO, Calif., March 11 Raven,biotechnologies, ... discovery,and development of monoclonal antibody therapeutics (MAbs) for ... the RAV12 Phase,1/2a trial has been accepted as ... of the American Society of Clinical Oncology (ASCO).,The ...
... Customer Advisory Board Programs Exemplify, Why ... Management Market, OTTAWA, March 11 /PRNewswire/ - ... performance and talent management software,announced today that its ... issues and challenges and play a critical role ...
Cached Biology Technology:Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 2Raven Announces RAV12 Phase 1/2a Study Results To Be Presented at ASCO 3Halogen Customers Shape Industry-Leading Employee Performance and Talent Management Solution 2Halogen Customers Shape Industry-Leading Employee Performance and Talent Management Solution 3
... SpeedVac™ Concentrators set the standard for sample concentration ... with large chamber uses a combination of centrifugal ... in a single run. , SC210A comes equipped ... for long lasting chemical compatibility ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
... series of vacuum concentrators/centrifugal evaporators offers a ... to rapid and safe concentration of heat-labile ... with oil-free or high vacuum pumps, a ... selection of rotors (eliminating sample loss by ...
... George Paxinos Affiliation: School of Psychology, The University ... Affiliation: Curtin University of Technology, Perth, Australia This ... of the rat brain. It is a ... revison and extension of the compact 3rd edition. ...
Biology Products: