Navigation Links
USC researchers identify 'regulatory' genetic sequences that may predict risk for prostate cancer
Date:8/14/2009

Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.

The findings, published today in the Public Library of Science (PLoS) Genetics journal, found mechanisms involved in cancer-associated sites in areas where no genes are present (gene 'deserts') at a chromosomal region called 8q24. The new findings show that some of these sites have embedded regulatory sequences that act as enhancers of gene expression, modulated by genetic variation, or single nucleotide polymorphisms (SNPs).

The two-year study, conducted by researchers from USC, Harvard University and the Weizmann Institute of Tel Aviv, Israel, found novel functions of SNPs in areas where no genes were present. They found how the SNPs are able to modulate genetic expression even while they were near no genes. SNPs denote a modest increase in risk for certain diseases; in this particular chromosomal area, the SNPs appear to be influencing gene expression for prostate (and other) cancer 'at a genetic distance'.

"The real contribution of this discovery is that we get a feel for a previously unappreciated mechanism that may be a predisposition to this disease," said Gerhard (Gerry) Coetzee, Ph.D., professor of urology and preventive medicine at the Keck School of Medicine and principal investigator on the study. "We have unearthed a new way to understand the risk for prostate cancer."

The study was prompted by discrepancies in prostate cancer risk among ethnic groups. Currently, risk factors for prostate cancer are governed by age, and a disproportionate increased risk chiefly among African-American men, with Caucasian men following and Asian men last. This gene 'desert' featuring versions of particular SNPs are found more often in African-American men and may explain their increased risk for the disease.


'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1

Related biology news :

1. K-State lab gives researchers the tools to study porcine circovirus associated diseases
2. Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech
3. SLAC researchers reveal the dance of water
4. McGill/JGH researchers successfully reverse multiple sclerosis in animals
5. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
6. Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding
7. University of Hawaii at Manoa researchers reveal ocean acidification at Station ALOHA
8. UBC researchers find first-ever wanderlust gene in tiny bony fish
9. Pitt researchers find promising candidate protein for cancer prevention vaccines
10. K-State researchers say after-school programs should promote activity, healthy nutrition
11. MU researchers create drought conditions to unearth solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... Research and Markets has announced the addition of the ... report to their offering. ... The biometric vehicle access system market, in terms ... from 2016 to 2021. The market is estimated to be USD ... by 2021. The growth of the biometric vehicle access system market ...
(Date:12/15/2016)... , Dec. 15, 2016 ... driving experience, health wellness and wellbeing (HWW), ... one in three new passenger vehicles begin ... recognition, gesture recognition, heart beat monitoring, brain ... monitoring, facial monitoring, and pulse detection. These ...
(Date:12/8/2016)...  Singulex, Inc., the leader in Next Generation Immunodiagnostics ... license and supply agreement with Thermo Fisher Scientific, the ... access to Thermo Scientific BRAHMS PCT (Procalcitonin), a biomarker ... to diagnose systemic bacterial infection and sepsis and in ... in assessing the risk of critically ill patients for ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... ... 18, 2017 , ... uBiome, the leading microbial genomics company, ... Editor, Dr. Elisabeth Bik, in the December 2016 issue of the Dutch Journal ... October 2016 from her previous position at Stanford University School of Medicine and ...
(Date:1/18/2017)... -- HUYA Bioscience International, (HUYA), the leader in accelerating the ... innovations, announced today a strategic collaboration agreement with the ... to as CAS Innovation). The collaboration will focus on ... at CAS to meet the medical needs of patients ... company to have recognized China,s ...
(Date:1/18/2017)... Research Future published a half-cooked research report on Global Cancer Diagnostics ... CAGR of 12% during the period 2016 to 2022. ... ... without any control. These abnormal cells have the ability to invade ... spread to other parts of the body through the blood and ...
(Date:1/17/2017)... , Jan. 17, 2017 The ... at a CAGR of around 7.5% over the ... 2025. Some of the prominent trends that the ... incidences of diseases & graft transplant surgeries and ... Material the market is categorized into immunomodulatory biomaterials, ...
Breaking Biology Technology: