Navigation Links
USC researchers identify 'regulatory' genetic sequences that may predict risk for prostate cancer

Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.

The findings, published today in the Public Library of Science (PLoS) Genetics journal, found mechanisms involved in cancer-associated sites in areas where no genes are present (gene 'deserts') at a chromosomal region called 8q24. The new findings show that some of these sites have embedded regulatory sequences that act as enhancers of gene expression, modulated by genetic variation, or single nucleotide polymorphisms (SNPs).

The two-year study, conducted by researchers from USC, Harvard University and the Weizmann Institute of Tel Aviv, Israel, found novel functions of SNPs in areas where no genes were present. They found how the SNPs are able to modulate genetic expression even while they were near no genes. SNPs denote a modest increase in risk for certain diseases; in this particular chromosomal area, the SNPs appear to be influencing gene expression for prostate (and other) cancer 'at a genetic distance'.

"The real contribution of this discovery is that we get a feel for a previously unappreciated mechanism that may be a predisposition to this disease," said Gerhard (Gerry) Coetzee, Ph.D., professor of urology and preventive medicine at the Keck School of Medicine and principal investigator on the study. "We have unearthed a new way to understand the risk for prostate cancer."

The study was prompted by discrepancies in prostate cancer risk among ethnic groups. Currently, risk factors for prostate cancer are governed by age, and a disproportionate increased risk chiefly among African-American men, with Caucasian men following and Asian men last. This gene 'desert' featuring versions of particular SNPs are found more often in African-American men and may explain their increased risk for the disease.


Contact: Leslie Ridgeway
University of Southern California

Page: 1

Related biology news :

1. K-State lab gives researchers the tools to study porcine circovirus associated diseases
2. Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech
3. SLAC researchers reveal the dance of water
4. McGill/JGH researchers successfully reverse multiple sclerosis in animals
5. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
6. Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding
7. University of Hawaii at Manoa researchers reveal ocean acidification at Station ALOHA
8. UBC researchers find first-ever wanderlust gene in tiny bony fish
9. Pitt researchers find promising candidate protein for cancer prevention vaccines
10. K-State researchers say after-school programs should promote activity, healthy nutrition
11. MU researchers create drought conditions to unearth solutions
Post Your Comments:
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
Breaking Biology Technology: