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USC researchers identify mechanism that controls activation of stem cells during hair regeneration
Date:1/16/2008

communicate activation signals among themselves. At different time points the macro-environment can be either permissive or suppressive for stem cell activation.

"Our research shows that the formation of new tissues or organs from stem cells -- such as the formation of new hairs -- can be more robust if it occurs in a permissive macro-environment," says Maksim Plikus, Ph.D., a post-doctoral fellow and the first author of the study. "I hope that our research will draw more attention to the hair follicle as the model for physiological regeneration in mammals, and as an abundant source of adult stem cells for the purposes of stem cell therapy."

"The work also has critical implications for research using the mouse skin as a model for tumor growth or drug delivery," Chuong notes. "Many of these studies assume the mouse skin is a homogeneous and stable environment for testing, but variations in results were obtained. Understanding this unexpected dynamics of the living mouse skin will help their experimental designs."


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Contact: Meghan Lewit
lewit@usc.edu
323-442-3576
University of Southern California
Source:Eurekalert

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