Navigation Links
USC researchers identify mechanism that controls activation of stem cells during hair regeneration
Date:1/16/2008

Los Angeles, Jan. 16, 2007 -- Researchers at the University of Southern California (USC) have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature.

"Conceptually, the findings have important implications for stem cell research and in understanding how stem cell activity is regulated during regeneration," says Cheng-Ming Chuong, M.D., Ph.D., principal investigator and professor of pathology at the Keck School of Medicine of USC. "The research presents a new dimension for the regulation of hair re-growth and ultimately organ regeneration."

The hair is an important model for organ regeneration in mammals because it is one of the few organs that regenerate regularly, Chuong notes. Recent work in the field has established hair cycling as one of the mainstream models for organ regeneration. However, most of these works focus on the cyclic regeneration of one single hair follicle, he says.

"Each of us has thousands of hair follicles. In our study, we were motivated to analyze the coordinative behavior of cyclic regeneration in a population of organs," Chuong says.

The research team found that hairs, even in normal mice, regenerate in waves, rather than individually. The findings suggest that hair stem cells are regulated not only by the micro-environment within one hair follicle -- as has previously been thought -- but also by adjacent hair follicles, other skin compartments and systemic hormones, in a hierarchical order.

At the molecular level, the findings showed that periodic expression of Bmp in the skin macro-environment appears to be at the center of the mechanism for coordinated hair stem cell activation. When many hairs regenerate, they must communicate activation signals among themselves. At different time points the macro-environment can be either permissive or suppressive for stem cell activation.

"Our research shows that the formation of new tissues or organs from stem cells -- such as the formation of new hairs -- can be more robust if it occurs in a permissive macro-environment," says Maksim Plikus, Ph.D., a post-doctoral fellow and the first author of the study. "I hope that our research will draw more attention to the hair follicle as the model for physiological regeneration in mammals, and as an abundant source of adult stem cells for the purposes of stem cell therapy."

"The work also has critical implications for research using the mouse skin as a model for tumor growth or drug delivery," Chuong notes. "Many of these studies assume the mouse skin is a homogeneous and stable environment for testing, but variations in results were obtained. Understanding this unexpected dynamics of the living mouse skin will help their experimental designs."


'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3576
University of Southern California
Source:Eurekalert

Related biology news :

1. Researchers put the bite on mosquitoes
2. Researchers find association between food insecurity and developmental risk in children
3. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
4. Japanese and German researchers meet to discuss climate change
5. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
6. Researchers uncover new piece to the puzzle of human height
7. Researchers create mathematical model of fruit fly eyes
8. Snoozing worms help Penn researchers explain the evolution of sleep
9. Researchers move 2 steps closer to understanding genetic underpinnings of autism
10. Rices West honored as one of Texas best researchers
11. Stanford researchers publish review of US medical device regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:5/12/2016)... 12, 2016 WearablesResearch.com , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... Kablooe Design, a leading provider of product design ... 25th anniversary of the business. “We have worked hard to build long-term relationships,” says ... the privilege and honor of serving their product design and development needs through the ...
(Date:5/19/2016)... MAPLE RIDGE, British Columbia , May 19, ... of AdvanTec Global Innovations Inc. (AGI), based out ... recently added Greenlane Biogas Ltd. to its ... a 2-year contract manufacturing agreement. AFS along with ... Bending Technologies (ABT) is a vertically integrated industrial ...
(Date:5/19/2016)... -- - I dati saranno presentati nel ... ° Congresso della Società Americana ... - Le conclusioni dello studio indicano un tasso di risposta ... il 90% presenta una d urata della risposta (Duration ... per cento dei pazienti ha riscontrato un beneficio clinico. ...
(Date:5/18/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that STACS-CW Enterprise ... help them save time and reduce errors. , Sexual Assault kits are receiving an ... informed of results. Due to a previous lack of tools, many forensic DNA laboratories ...
Breaking Biology Technology: