Navigation Links
USC researchers identify mechanism that controls activation of stem cells during hair regeneration
Date:1/16/2008

Los Angeles, Jan. 16, 2007 -- Researchers at the University of Southern California (USC) have identified a novel cyclic signaling in the dermis that coordinates stem cell activity and regulates regeneration in large populations of hairs in animal models. The signaling switch involves bone morphogenetic protein (Bmp) pathway, according to the study that will be published in the Jan. 17 issue of the journal Nature.

"Conceptually, the findings have important implications for stem cell research and in understanding how stem cell activity is regulated during regeneration," says Cheng-Ming Chuong, M.D., Ph.D., principal investigator and professor of pathology at the Keck School of Medicine of USC. "The research presents a new dimension for the regulation of hair re-growth and ultimately organ regeneration."

The hair is an important model for organ regeneration in mammals because it is one of the few organs that regenerate regularly, Chuong notes. Recent work in the field has established hair cycling as one of the mainstream models for organ regeneration. However, most of these works focus on the cyclic regeneration of one single hair follicle, he says.

"Each of us has thousands of hair follicles. In our study, we were motivated to analyze the coordinative behavior of cyclic regeneration in a population of organs," Chuong says.

The research team found that hairs, even in normal mice, regenerate in waves, rather than individually. The findings suggest that hair stem cells are regulated not only by the micro-environment within one hair follicle -- as has previously been thought -- but also by adjacent hair follicles, other skin compartments and systemic hormones, in a hierarchical order.

At the molecular level, the findings showed that periodic expression of Bmp in the skin macro-environment appears to be at the center of the mechanism for coordinated hair stem cell activation. When many hairs regenerate, they must
'/>"/>

Contact: Meghan Lewit
lewit@usc.edu
323-442-3576
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers put the bite on mosquitoes
2. Researchers find association between food insecurity and developmental risk in children
3. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
4. Japanese and German researchers meet to discuss climate change
5. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
6. Researchers uncover new piece to the puzzle of human height
7. Researchers create mathematical model of fruit fly eyes
8. Snoozing worms help Penn researchers explain the evolution of sleep
9. Researchers move 2 steps closer to understanding genetic underpinnings of autism
10. Rices West honored as one of Texas best researchers
11. Stanford researchers publish review of US medical device regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today announced the ... ancestry of individuals from across the United States ... four hundred years ago, the United States ... different continents. This study illuminates how American history and the ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor ... leaders such as Intel, Jabra, Atlas, and Scosche to ... These products will be showcased at CES 2015, taking ... . "Our partners choose PerformTek biometrics, ...
(Date:12/11/2014)... 2014 Research and Markets , ... has announced the addition of the "Biometrics Market ... One major trend emerging in this market ... systems utilize more than one characteristic of an individual ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... to a REM sleep deprivation procedure reduces cell proliferation ... long-term memory of rats, according to a study published ... The study, authored by Dennis McGinty, PhD, of ... male Sprague-Dawley rats. REM sleep deprivation was achieved ...
... experimental biomarker test developed by researchers at the University ... other screening method currently in use, according to a ... Research, a journal of the American Association for Cancer ... that screens for the presence of four different ...
... the worlds poorest regions could face severe crop losses in ... a new study by researchers at Stanford Universitys Program on ... be published in the Feb. 1 issue of the journal ... depend on agriculture for their livelihoods, said lead author David ...
Cached Biology News:4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats 2New, noninvasive prostate cancer test beats PSA in detecting prostate cancer 2New, noninvasive prostate cancer test beats PSA in detecting prostate cancer 3Impoverished areas of Africa and Asia face severe crop losses from climate change in 20 years 2Impoverished areas of Africa and Asia face severe crop losses from climate change in 20 years 3Impoverished areas of Africa and Asia face severe crop losses from climate change in 20 years 4
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Eckert ... Accelerator Mass Spectrometry (AMS) services to the pharmaceutical and ... has joined the company in the position of Director ... years of broad and valuable experience in drug metabolism ...
(Date:1/22/2015)... 2015 Cambridge Semantics, the leading provider of ... that 2014 was a record-breaking year across the board for ... Anzo Smart Data Platform and our Smart Data solutions, our ... diverse data which led to record growth for the company ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... May 11 deCODE genetics,(Nasdaq: DCGN ) today ... 31, 2009. A conference call to discuss these results ... live tomorrow,Tuesday, May 12, at 8:00am Eastern Daylight Time/12 ... Net loss for the quarter ended March ...
... May 11 Sinobiopharma, Inc. (OTC Bulletin Board: ... announce that it has received approval from the ... manufacture and market its formulation of Perindopril, an ... other medications to treat high blood pressure, is ...
... helps healthcare providers build competence and confidence while keeping ... Corporation ( MSC ) will launch the ... Teaching Institute (NTI) and Critical Care Exposition, the world,s ... critically ill patients, May 16-21, in New Orleans, LA. ...
Cached Biology Technology:deCODE genetics Announces First Quarter 2009 Financial Results 2deCODE genetics Announces First Quarter 2009 Financial Results 3deCODE genetics Announces First Quarter 2009 Financial Results 4deCODE genetics Announces First Quarter 2009 Financial Results 5deCODE genetics Announces First Quarter 2009 Financial Results 6deCODE genetics Announces First Quarter 2009 Financial Results 7deCODE genetics Announces First Quarter 2009 Financial Results 8Sinobiopharma Announces SFDA Approval of Anti-Hypertension Drug Perindopril 2Medical Simulation Corporation to Introduce Central Line Management Program at the National Teaching Institute and Critical Care Exposition 2Medical Simulation Corporation to Introduce Central Line Management Program at the National Teaching Institute and Critical Care Exposition 3
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
This modular laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Configurations are available with vertical or horizontal flow; options include a wo...
...
Denhardt's powder mixture (for 50X stock solution)...
Biology Products: