Navigation Links
USC researchers find new clues about protein linked to Parkinson's disease
Date:6/17/2011

Researchers at the Keck School of Medicine of the University of Southern California (USC) have uncovered structural clues about the protein linked to Parkinson's disease (PD), which ultimately could lead to finding a cure for the degenerative neurological disorder.

The alpha-synuclein (α-synuclein) protein is commonly found in the healthy human brain even though its function is not clear. The protein has been the subject of substantial Parkinson's research, however, because it is a major component in the protein clumps found in PD cases.

Unlike most proteins, which are typically rigid and occur in one definitive form, the alpha-synuclein protein can fold and change its structure. Researchers Tobias S. Ulmer, Ph.D. and Sowmya Bekshe Lokappa, Ph.D. at the Keck School-affiliated Zilkha Neurogenetic Institute have determined that the energy difference between two particular alpha-synuclein structures is less than previously speculated.

Their study, to be published in the June 17 issue of The Journal of Biological Chemistry, is the first to quantify that energy difference, 1.20.4 kcal/mol.

"We're trying to understand the mechanisms of protein folding and misfolding," said Ulmer, the study's principal investigator and an assistant professor in the Department of Biochemistry and Molecular Biology at the Zilkha Neurogenetic Institute. "Then we can say why something is going wrong, which is essential to treating neurodegenerative disorders like Parkinson's."

If proteins misfold, they are repaired or they break down. However, when alpha-synuclein misfolds it aggregates and becomes toxic to surrounding nerve cells, Ulmer said. Understanding its folding and finding what causes aberrant folding is therefore key to determining the root cause of the disorder, he added.

To put the discovery into perspective, Ulmer compared the energy that researchers thought was needed to change the protein's structure to hurri
'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW researchers receive award from NCI to study cancer from a neglected tropical disease
2. MSU plant scientist named one of the nations most innovative researchers
3. Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find
4. Researchers predict record Gulf of Mexico dead zone due to Mississippi River flooding
5. Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
6. Researchers improve method for finding genetic mistakes that fuel cancer
7. Johns Hopkins researchers link cell division and oxygen levels
8. U-M researchers find potential new way to fight sepsis
9. Penn researchers show new evidence of genetic arms race against malaria
10. Penn researchers develop biological circuit components, new microscope technique for measuring them
11. Researchers discover potential cause of chronic painful skin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... need to produce hydrogen sulfide in order to properly ... study from the Center for Craniofacial Molecular Biology at ... Professor Songtao Shi, principal investigator on the project, said ... governs the flow of calcium ions. The essential ions ... osteogenesis, or the creation of new bone tissue, and ...
(Date:4/17/2014)... of forests in the Amazon help create tinderbox ... rapid and widespread forest loss during drought years, ... show that forests in the Amazon could reach ... forest fires lead to large-scale loss of trees, ... professor of geography, Penn State. , "We documented ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... (Washington, DC) The American Society for Bone and ... scientific meeting in the world on bone and mineral ... research, technology and new clinical treatments in bone diseases ... year,s Annual Meeting, being held in Baltimore, MD USA, ...
... 2013, Cleveland: Cleveland Clinic,s 8th Annual Obesity Summit will bring ... 17, 2013, at the InterContinental Hotel and Bank of America ... the escalating obesity epidemic in the United States. ... every six children are obese. In addition to causing health ...
... been vilified for detrimental effects to water quality and fish ... "ecological and engineering resilience" to climate change in the Columbia ... Canadian journal Atmosphere-Ocean , looked at the effects of ... reaches of seven sub-basins of the Columbia River from 1950 ...
Cached Biology News:American Society for Bone and Mineral Research Annual Meeting Oct. 4-7 2Cleveland Clinic's 2013 Obesity Summit explores causes, prevention and treatment of obesity 2Dams provide resilience to Columbia River basin from climate change impacts 2
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal Products ... selected by Buffalo BioBlower Technologies LLC ("B3") as the ... Phase 2 award from the Army Corps of Engineers.  ... that kills all biological contaminants and destroys VOCs and ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... , January 15, 2014 A study ... races on the Formula 1 track could help to tackle ... Applied Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... healthcare provider Simplyhealth. Telemetry technology, which is inspired ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... a provider of health-care and business technology, announced a seven-year ... Medicaid Management Information System (MMIS). The new system is expected ... in November, contracts EDS to implement its InterChange health system ... and Family Services . The contract is worth approximately $189 ...
... Inc. , a provider of education products in Wisconsin ... subsidiary's president, John Stearns. , ,Generation21 lost $4.6 million ... Renaissance Learning said it had looked for strategic alternatives ... to Stearns was its best option. , ,The company ...
... Greenspan, chairman of the Federal Reserve Bank, is famous ... (and sounding smart doing it). Recently however, he managed ... skills problem that now exists within the American workforce. ... his semi-annual report to Congress on February 12, 2005 ...
Cached Biology Technology:State picks long-time vendor for $189m Medicaid information system 2Is America prepared to win the global skills race? 2Is America prepared to win the global skills race? 3Is America prepared to win the global skills race? 4
... Roche Applied Science, which pioneered the ... Expand High Fidelity and Expand Long Template ... FidelityPLUS PCR System the first product ... This new blend combines Taq DNA ...
The HEPTEST assays provide a sensitive, simple, rapid, and convenient in vitro quantitation of heparin, low molecular weight heparins, and heparinoids in plasma and whole blood. Sample Type: wh...
...
... Synergistic enzyme mix (Thermoprime Plus DNA Polymerase ... least four times higher fidelity than standard ... standard Taq DNA polymerase, Amplifies DNA templates ... long PCR, PCR for cloning and mutagenesis ...
Biology Products: