Navigation Links
USC researchers find new clues about protein linked to Parkinson's disease
Date:6/17/2011

Researchers at the Keck School of Medicine of the University of Southern California (USC) have uncovered structural clues about the protein linked to Parkinson's disease (PD), which ultimately could lead to finding a cure for the degenerative neurological disorder.

The alpha-synuclein (α-synuclein) protein is commonly found in the healthy human brain even though its function is not clear. The protein has been the subject of substantial Parkinson's research, however, because it is a major component in the protein clumps found in PD cases.

Unlike most proteins, which are typically rigid and occur in one definitive form, the alpha-synuclein protein can fold and change its structure. Researchers Tobias S. Ulmer, Ph.D. and Sowmya Bekshe Lokappa, Ph.D. at the Keck School-affiliated Zilkha Neurogenetic Institute have determined that the energy difference between two particular alpha-synuclein structures is less than previously speculated.

Their study, to be published in the June 17 issue of The Journal of Biological Chemistry, is the first to quantify that energy difference, 1.20.4 kcal/mol.

"We're trying to understand the mechanisms of protein folding and misfolding," said Ulmer, the study's principal investigator and an assistant professor in the Department of Biochemistry and Molecular Biology at the Zilkha Neurogenetic Institute. "Then we can say why something is going wrong, which is essential to treating neurodegenerative disorders like Parkinson's."

If proteins misfold, they are repaired or they break down. However, when alpha-synuclein misfolds it aggregates and becomes toxic to surrounding nerve cells, Ulmer said. Understanding its folding and finding what causes aberrant folding is therefore key to determining the root cause of the disorder, he added.

To put the discovery into perspective, Ulmer compared the energy that researchers thought was needed to change the protein's structure to hurri
'/>"/>

Contact: Alison Trinidad
alison.trinidad@usc.edu
323-442-3941
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. GW researchers receive award from NCI to study cancer from a neglected tropical disease
2. MSU plant scientist named one of the nations most innovative researchers
3. Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find
4. Researchers predict record Gulf of Mexico dead zone due to Mississippi River flooding
5. Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
6. Researchers improve method for finding genetic mistakes that fuel cancer
7. Johns Hopkins researchers link cell division and oxygen levels
8. U-M researchers find potential new way to fight sepsis
9. Penn researchers show new evidence of genetic arms race against malaria
10. Penn researchers develop biological circuit components, new microscope technique for measuring them
11. Researchers discover potential cause of chronic painful skin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... by neurobiologist Luke Remage-Healey at the University of ... the brains of young birds enhance their ability ... development. This period has a parallel to universal ... separate study, the UMass Amherst neuroscientist and colleagues ... the brain,s auditory cortex enhances the representation of ...
(Date:7/21/2014)... runoff is causing problems for the world,s water ... Agency found stormwater runoff to be one of ... rivers, streams, lakes, ponds, reservoirs, bays, and estuaries. ... fish and wildlife populations, foul drinking water, and ... Carolina State University are looking to rain gardens ...
(Date:7/21/2014)... Cystoid macular edema (CME) is a common complication ... in which patients typically lose night and side vision ... also decrease central vision. Current treatments for CME in ... adverse results. , Researchers from the Massachusetts Eye and ... Medicine tested whether the extent of retinal swelling due ...
Breaking Biology News(10 mins):Studying estrogens made by the brain may offer new insights in learning and memory 2Studying estrogens made by the brain may offer new insights in learning and memory 3Filter bed substrates, plant types recommended for rain gardens 2Iodine may alleviate swelling in retinitis pigmentosa patients' retinas 2
... have much in common with a Rottweiler, you might be ... a cave in the Altai Mountains of Siberia for 33,000 ... domestication and, together with equally ancient dog remains from a ... occurred repeatedly in different geographic locations rather than with a ...
... is available in German . Mate ... animal species. During mating season male testosterone levels rise, ... features. Male bonobos, however, invest much more into friendly ... collide with this increased tendency towards forming pair-relationships. ...
... 26 million Americans with diabetes, drawing blood is the ... invasive and at least minimally painful. Researchers at Brown ... check blood sugar levels by measuring glucose concentrations in ... convergence of nanotechnology and surface plasmonics, which explores the ...
Cached Biology News:Dog skull dates back 33,000 years 2Dog skull dates back 33,000 years 3Bonobos' unusual success story 2Biochip measures glucose in saliva, not blood 2Biochip measures glucose in saliva, not blood 3
(Date:7/18/2014)... 18, 2014  On July 18, 2014, ... Shire,s complementary fit and the benefits of ... of the infographic materials will be available ... In accordance with Rule 30.4 ... this announcement will be available on AbbVie,s ...
(Date:7/18/2014)... , July 18, 2014 ... in Animal Research for the third consecutive year. The ... University, will attend a 1-week course at Zürich University ... the 3Rs (Replace, Reduce, Refine). As head of the ... has been given the task of adapting experimental animal ...
(Date:7/17/2014)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ), a ... products for the treatment of central nervous system disorders, ... quarter of 2014 on Thursday, August 7, 2014, before ... host a conference call at 10:00 AM ET on ... discuss the second quarter 2014 financial results and other ...
(Date:7/17/2014)... MELBOURNE, Australia , July 17, 2014  Prana ... today provided an update on its clinical development program ... , the Florey Institute of Neuroscience and Mental Health, ... Prana,s Phase 2 IMAGINE and EURO trials in his ... Copenhagen, Denmark . The presentation ...
Breaking Biology Technology:NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 2NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 3NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 4NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 5NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 6NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 7Young Moscovite Researcher Receives this Year's "Basel Declaration Award for Education in Animal Research" 2Vanda Pharmaceuticals to Announce Second Quarter 2014 Financial Results on August 7, 2014 2Prana Alzheimer's disease Development Program update 2Prana Alzheimer's disease Development Program update 3Prana Alzheimer's disease Development Program update 4Prana Alzheimer's disease Development Program update 5
... www.mchange.org Milwaukee As the highway reconstruction ... leveled at the amount of money, $685,000, spent on a ... , ,The Web site for the Marquette Interchange Project ... a joint venture between the consultants working on the interchange, ...
... sell advertising to competitors of Geico Corp. who use ... court in Virginia has ruled. Advertising based on Web ... Googles business. In the third quarter, about half of ... also called sponsored links. , ,This case involved ...
... companies out there will give you a logo at no cost, ... free Web site. I guess the nextbig thing will be that ... and how are they doing this? , ,The Internet has removed ... issues in real time without the fancy decorum and the big-time ...
Cached Biology Technology:$685,000 too much for construction Web site, critics say 2$685,000 too much for construction Web site, critics say 3Google wins first battle in trademark war 2Free branding? Why not? 2Free branding? Why not? 3
GOAT ANTI FRK...
... Spots and complementary RNA Spikes for the ... for glass array printing and for protocol ... cDNA labeling, hybridization stringency and background. Normalize ... Spots and Oligo Spots, and complementary RNA ...
MOUSE ANTI S. MUTANS PEPTIDOGLYCAN...
For the quantitative determination of canine Interleukin 10,(IL-10) concentrations in cell culture supernates, canine serum,and plasma....
Biology Products: