Navigation Links
USC researchers discover genetic mutation causing excessive hair growth
Date:6/3/2011

ly. When the Mexican family was examined, a piece of chromosome 4 was found to be inserted into the same part of the X chromosome, thus confirming that these extremely rare events caused the disorder."

The investigators suggest that insertion of the "extra" DNA sequences into the X chromosome apparently turns on a gene, likely SOX3, located near the insertion site. SOX3 is a strong candidate because other members of this gene family have been shown to play a role in hair growth.

In addition, the insertion has occurred within a block of DNA sequence called a "palindrome," in which the sequence of the four building blocks of DNA (akin to letters of the alphabet) read exactly the same as their complementary sequences, but in the reverse direction. The particular palindrome at the site that the researchers studied is only found in humans.

"We don't yet know the significance of the palindromic sequence in this case," Patel said. "But it appears to be unstable, and can be entirely absent in many individuals with normal hair growth. It's only when there is insertion of certain chromosome segments at this site that people have extra hair."

Earlier, researchers had theorized that the CGH mutation is "atavistic" a trait that reappears after being absent for a long time. One example of an atavistic trait is extra nipples in both men and women.

"It's like the information is there in the genome, but is silenced," Patel said. "Then somehow it's reactivated, and can manifest as the trait. We don't know yet if this is the case with CGH."

Further studies will test if this is indeed true. "If in fact the inserted sequences turn on a gene that can trigger hair growth, it may hold promise for treating baldness or hirsutism [excessive hair growth] in the future, especially if we could engineer ways to achieve this with drugs or other means," Patel said.


'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Eating dirt can be good for the belly, researchers find
2. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
3. UNH researchers receive grant for pioneering carbon cycle model
4. Penn researchers help nanoscale engineers choose self-assembling proteins
5. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
6. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
7. What is a laboratory mouse? Jackson, UNC researchers reveal the details
8. MDC researchers discover key molecule for stem cell pluripotency
9. Researchers track the secret lives of feral and free-roaming house cats
10. UTHealth researchers find diabetics at higher risk of tuberculosis infection
11. UT Southwestern researchers find protein breakdown contributes to pelvic organ prolapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... September 2, 2014 Best-selling author Sam Kean stops ... the Megalodon, the 50-foot super shark that, despite what ... extinct. Learn all about it at http://youtu.be/KhFygIoW_MA . ... Tales of Madness, Love and the History of the ... getting the Reactions treatment in a 10-episode video series ...
(Date:9/2/2014)... done in by it. New research at Rockefeller University ... gap in mice with very similar genetic backgrounds ... the development of psychiatric disorders such as anxiety and ... as it goes through its life. And we suspect ... genes, and as a result, affect an animal,s susceptibility ...
(Date:9/1/2014)... the U.S. undergoes a battery of tests designed to ... Thousands of children born in the developing world, however, ... the disease each year. , A.J. Kumar hopes ... those deaths. , A Post-Doctoral Fellow in Chemistry ... Whitesides, the Woodford L. and Ann A. Flowers University ...
Breaking Biology News(10 mins):Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3
... school students and teachers sounds like a witches brew for an ... Instead, these are the components that comprise the ... developed by researchers at Washington University in St. Louis and a ... Lars Angenent, Ph.D., assistant professor of ...
... a pair of proteins that work in concert to restart ... dormancy. The Hawley Lab has described the dual ... that awakens the long-dormant egg, allowing for production of a ... Dec. 4, 2007 issue of PLoS Biology. The ...
... may have begun in the protected spaces inside of layers ... new hypothesis. The hypothesis was developed by Helen Hansma, ... and a program director at the National Science Foundation. Hansma ... Dec. 4, at the annual meeting of the American Society ...
Cached Biology News:Microbial fuel cells turn on the juice 2Microbial fuel cells turn on the juice 3Stowers Institute's Hawley Lab identifies factors responsible for restart of meiotic cycle 2New hypothesis for origin of life proposed 2
(Date:9/2/2014)... -- Scientists, including University of Oregon chemist Geraldine ... scaffolds of self-assembling, synthetic proteins called peptoid nanosheets ... The accomplishment -- detailed this week in a ... Proceedings of the National Academy of Sciences ... design of the two-dimensional peptoid nanosheets that can ...
(Date:9/2/2014)... Sept. 2, 2014  TransCelerate BioPharma Inc. ("TransCelerate") ... approach for protecting personal data in Clinical Study ... and others. The document describes an approach to ... CSRs and other related clinical trial documents, and ... goal of the TransCelerate CSR Redaction approach is ...
(Date:9/2/2014)... PA (PRWEB) September 02, 2014 ... a new highly efficient, cost effective approach to ... Patent No. 8,820,265 by the U.S. Patent and ... to Opertech. , “Opertech’s taste evaluation ... the first automated high throughput system for rapid ...
(Date:9/2/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (Nasdaq: ONTY ) announced ... Executive Officer, will present at the Rodman & Renshaw 16 ... York on Tuesday, Sept. 9, 2014 at 2:05 ... of the presentation will be accessible by visiting the Oncothyreon ... About Oncothyreon Oncothyreon is ...
Breaking Biology Technology:UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 2TransCelerate BioPharma Inc. Releases Recommended Approach for Protecting Personal Data in Clinical Study Reports 3Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2
... , SUNNYVALE, Calif., Oct. 13 Cepheid (Nasdaq: CPHD ... its third quarter ended September 30, 2009, on Wednesday, October ... company will host a management presentation at 2 p.m. Pacific ... To access the live webcast, please visit Cepheid,s website ...
... Novavax, Inc. (Nasdaq: NVAX ) announced today that it ... from the National Institute of Allergy and Infectious Diseases (NIAID) ... from the NIAID is to support a segment of the ... particle-based vaccine. RSV is the most commonly identified cause ...
... CAMBRIDGE, Mass., Oct. 13 Cequent Pharmaceuticals, a pioneer ... treatments to prevent and treat human disease, announced that ... Cequent,s planned launch of its clinical program and highlight ... for 3 p.m. on Tuesday, October 27, 2009, at ...
Cached Biology Technology:Cepheid Schedules 2009 Third Quarter Financial Results Announcement and Webcast 2Novavax Awarded NIH Grant for Respiratory Syncytial Virus (RSV) Vaccine Program 2Novavax Awarded NIH Grant for Respiratory Syncytial Virus (RSV) Vaccine Program 3Cequent to Provide Details at BIOCOM About Planned Launch of its Clinical Program - 3 p.m., Tuesday, October 27 2
... Blot Processing Standard Tray (3 ... for gel staining and blot processing.Automated ... gels for proteins and nucleic acid ... detection and chromogenic detection.Programmable control of ...
... Dithiothreitol, 1 g. High quality ... sample preparation that give consistent ... cells and tissues.Clean up samples ... volumes. Accurately quantitate protein for ...
IMAGEQUANT 300 WKSTN, 1 EA. Category: ImageQuant CCD Imagers....
ANTI MYCOBACTERIUM TUBERCULOSIS...
Biology Products: