Navigation Links
USC researcher reveals how to better master stem cells' fate
Date:10/24/2013

USC scientist Qi-Long Ying and a team of researchers have long been searching for biotech's version of the fountain of youth ways to encourage embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) to endlessly self-renew, or divide to produce more stem cells.

In a pair of studies published in Nature Communications in September and in The EMBO Journal in August, Ying and his team revealed some of the ways that ESCs and EpiSCs retain their pluripotency, or ability to differentiate into virtually any kind of cell.

The study in Nature Communications identified a novel way of culturing human ESCs by focusing on the Wnt/beta-catenin signaling pathway a group of molecules that work together to control various cell functions, including some related to embryonic development.

Slide1 rev

(Illustration by Qing Liu-Michael)

According to the researchers, this pathway can prompt mouse EpiSCs and human ESCs to either self-renew or differentiate. When the protein beta-catenin remains within the cell cytoplasm but outside of the nucleus, the stem cell continues to self-renew. When beta-catenin moves into a stem cell's nucleus, differentiation begins.

Slide2 rev

(Illustration by Qing Liu-Michael)

The paper published in The EMBO Journal addresses mouse ESCs, which are derived from the embryo at an earlier stage and are more pluripotent than mouse EpiSCs.

The study revealed the important role of Tfcp2l1 a transcription factor, or protein that controls which genes are turned on and off in a cell.

In mice, Tfcp2l1 helps communicate to ESCs that they should self-renew. The transcription factor also shows promise for "rewinding" slightly more differentiated EpiSCs into the more nave ESC state.

By learning more about the ESC and EpiSC playbooks, Ying and his colleagues can better control stem cell self-renewal, offering hope for patients with currently untreatab
'/>"/>

Contact: Cristy Lytal
lytal@med.usc.edu
University of Southern California - Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
2. USC researcher learns how to break a sweat
3. Researchers show how plants tell the time
4. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
5. Researchers capture images of open channel that moves proteins across cell membranes
6. UAlberta medical researchers discover potential new treatment for colitis
7. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
8. Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find
9. Researchers discover innate virus-killing power in mammals
10. CNIO researchers delve into the behavior of cohesins
11. AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC researcher reveals how to better master stem cells' fate
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences International ... has released a new series of digital telemetry ... toxicology researchers. M series, part of the PhysioTel™ ... the best possible physiologic data when incorporating functional ... functional endpoints to toxicology studies has evolved from ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today ... its School of Medicine. Funding for this $50 million ... that will be publicly launched next summer. ... the former 60 series R.J. Reynolds Tobacco Company complex, ... will begin immediately with plans to be ready to ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... panic disorder and obsessive-compulsive disorders, ,alcohol and drug dependence, ... of ,disorders of the brain. The size, the burden ... ,immense, and has so far been underestimated, as Prof. ... Conference to the 20th ECNP Congress for ,Neuropsychopharmacology in ...
... early ,90s have seen the potential for cleaning up contaminated ... pollutants through their roots. Then the plants break certain kinds ... into their roots, stems and leaves or release into the ... this is that the process is slow and halts completely ...
... framework of an ESA-supported project, is using satellite images ... to ensure the more efficient use of pesticides. ... be registered with the national members of the European ... data derived from field trials. EPPO has defined zones ...
Cached Biology News:Mental disorders are disorders of the brain 2Mental disorders are disorders of the brain 3Scientists ramp up ability of poplar plants to disarm toxic pollutants 2Scientists ramp up ability of poplar plants to disarm toxic pollutants 3Scientists ramp up ability of poplar plants to disarm toxic pollutants 4
(Date:12/24/2014)... 2014 Nashville Fertility Center announced that ... for the American Society for Reproductive Medicine (ASRM), a ... in reproductive medicine. In his new role as ... executive board and will have a voice in furthering ... actively supported ASRM since 1984 when he joined while ...
(Date:12/24/2014)... 2014 Vermillion, Inc. (Nasdaq:   VRML), ... announced today that investors including Oracle Investment Management, ... and several Vermillion directors have agreed to purchase ... common stock and warrants to purchase unregistered shares ... Under the terms of the ...
(Date:12/24/2014)... and NEW YORK , Dec. ... its open-label pilot study of mazindol in children with ... and Therapy in December 2014 . ... in children with attention deficit/hyperactivity disorder" ( Konofal et ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows that ...
(Date:12/22/2014)... 2014  Alternative Energy & Environmental Solutions, Inc., ... a letter of intent to acquire BioTechPharma Corporation, ... a nanotechnology-based development platform used to create drug ... on-site collection and testing to identify infectious disease, ... an immediate, non-invasive and cost-effective manner. ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2
... REYKJAVIK, Iceland, November 4 deCODE,genetics (Nasdaq: DCGN ... a,hearing before a Nasdaq Listing Qualifications Panel to ... Rule 4450(b)(1)(A), which,requires a minimum market value of ... deCODE received a Staff Determination Letter from The,Nasdaq ...
... - Oncothyreon Inc. (Nasdaq:,ONTY) (TSX:ONY), a biotechnology company ... the treatment of cancer, today,announced that Robert Kirkman, ... present at the Rodman & Renshaw Annual Global ... 11, 2008 at 11:35 a.m.,E.T., A live ...
... leading provider of,Business Process Management (BPM), Business ... for aligning strategy with execution,today announced that ... the premier global association for professionals involved ... acquisitions,selected Metastorm as an ACG Deal of ...
Cached Biology Technology:deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 2deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 3deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter 4Metastorm Selected as a Finalist in ACG Deal of the Year Awards 2
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... Neuromedin U-23 (rat) - Diluted Antiserum ... Family: Neuromedin U-23 (rat) Immunology Products, ... 2 For our corresponding peptide and ... peptide, please see Neuromedin U-23 (rat) (H-9295) ...
... vaccinia virus is a type I eukaryotic ... superhelical turns (also called right- and left-handed ... of the reaction is a covalently closed, ... superhelical turns. DNA Topoisomerase I does not ...
...
Biology Products: