Navigation Links
USC researcher reveals how to better master stem cells' fate
Date:10/24/2013

USC scientist Qi-Long Ying and a team of researchers have long been searching for biotech's version of the fountain of youth ways to encourage embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) to endlessly self-renew, or divide to produce more stem cells.

In a pair of studies published in Nature Communications in September and in The EMBO Journal in August, Ying and his team revealed some of the ways that ESCs and EpiSCs retain their pluripotency, or ability to differentiate into virtually any kind of cell.

The study in Nature Communications identified a novel way of culturing human ESCs by focusing on the Wnt/beta-catenin signaling pathway a group of molecules that work together to control various cell functions, including some related to embryonic development.

Slide1 rev

(Illustration by Qing Liu-Michael)

According to the researchers, this pathway can prompt mouse EpiSCs and human ESCs to either self-renew or differentiate. When the protein beta-catenin remains within the cell cytoplasm but outside of the nucleus, the stem cell continues to self-renew. When beta-catenin moves into a stem cell's nucleus, differentiation begins.

Slide2 rev

(Illustration by Qing Liu-Michael)

The paper published in The EMBO Journal addresses mouse ESCs, which are derived from the embryo at an earlier stage and are more pluripotent than mouse EpiSCs.

The study revealed the important role of Tfcp2l1 a transcription factor, or protein that controls which genes are turned on and off in a cell.

In mice, Tfcp2l1 helps communicate to ESCs that they should self-renew. The transcription factor also shows promise for "rewinding" slightly more differentiated EpiSCs into the more nave ESC state.

By learning more about the ESC and EpiSC playbooks, Ying and his colleagues can better control stem cell self-renewal, offering hope for patients with currently untreatable diseases and creating potential for a wide variety of other applications.

"These new findings have allowed us to develop conditions for the efficient propagation of human ESCs, and might also enable us to establish pluripotent stem cells from different species," said Ying, associate professor of stem cell biology and regenerative medicine at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. "This has far-reaching implications for a variety of applied areas of investigation, ranging from manipulating the genomes of agricultural animals to developing stem cell-based therapies for ailments such as Parkinson's disease or spinal cord injuries."


'/>"/>

Contact: Cristy Lytal
lytal@med.usc.edu
University of Southern California - Health Sciences
Source:Eurekalert  

Related biology news :

1. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
2. USC researcher learns how to break a sweat
3. Researchers show how plants tell the time
4. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
5. Researchers capture images of open channel that moves proteins across cell membranes
6. UAlberta medical researchers discover potential new treatment for colitis
7. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
8. Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find
9. Researchers discover innate virus-killing power in mammals
10. CNIO researchers delve into the behavior of cohesins
11. AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC researcher reveals how to better master stem cells' fate
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
(Date:6/23/2016)... SAN FRANCISCO , June 23, 2016   ... it has secured $1 million in debt financing from ... to ramp up automation and to advance its drug ... for its new facility. "SVB has been ... goes beyond the services a traditional bank would provide," ...
(Date:6/23/2016)... 2016  Blueprint Bio, a company dedicated to identifying, ... community, has closed its Series A funding round, according ... "We have received a commitment from Forentis Fund ... to meet our current goals," stated Matthew Nunez ... to complete validation on the current projects in our ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division of ... and optimized exclusively for Okuma CNC machining centers at The International Manufacturing Technology ... among several companies with expertise in toolholding, cutting tools, machining dynamics and distribution, ...
Breaking Biology Technology: