Navigation Links
USC researcher learns how to break a sweat
Date:10/23/2013

Without sweat, we would overheat and die. In a recent paper in the journal PLOS ONE, USC faculty member Krzysztof Kobielak and a team of researchers explored the ultimate origin of this sticky, stinky but vital substance sweat gland stem cells.

Kobielak and his team used a system to make all of the sweat gland cells in a mouse easy to spot: labeling them with green fluorescent protein (GFP), which is visible under ultraviolet light.

Over time, the GFP became dimmer as it was diluted among dividing sweat gland cells. After four weeks, the only cells that remained fluorescent were the ones that did not divide or divided very slowly a known property among stem cells of certain tissues, including the hair follicle and cornea. Therefore, these slow-dividing, fluorescent cells in the sweat gland's coiled lower region were likely also stem cells.

Then, the first author of this paper, graduate student Yvonne Leung, tested whether these fluorescent cells could do what stem cells do best differentiate into multiple cell types. To the researchers' surprise, these glowing cells generated not only sweat glands, but also hair follicles when placed in the skin of a mouse without GFP.

The researchers also determined that under certain conditions, the sweat gland stem cells could heal skin wounds and regenerate all layers of the epidermis.

"That was a big surprise for us that those very quiescent sweat gland stem cells maintain multilineage plasticity participating not only in their own regeneration, but also in the regeneration of hair follicles and skin after injury," said Kobielak, assistant professor of pathology at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.

This offers exciting possibilities for developing future stem cell-based treatments for skin and sweat gland-related conditions, such as hyperhidrosis or hypohidrosis (excessive or insufficient sweating). It could also lay the foundation for creating fully functional skin containing both sweat glands and hair follicles for burn victims.


'/>"/>

Contact: Marie Rippen
lytal@med.usc.edu
University of Southern California - Health Sciences
Source:Eurekalert  

Related biology news :

1. Researchers show how plants tell the time
2. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
3. Researchers capture images of open channel that moves proteins across cell membranes
4. UAlberta medical researchers discover potential new treatment for colitis
5. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
6. Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find
7. Researchers discover innate virus-killing power in mammals
8. CNIO researchers delve into the behavior of cohesins
9. AgriLife researcher Xiuren Zhang receives National Science Foundation CAREER grant
10. Rensselaer researchers propose new theory to explain seeds of life in asteroids
11. UT Dallas researchers find early success in new treatment for stroke recovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC researcher learns how to break a sweat
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... City, Missouri (PRWEB) , ... May 27, 2016 , ... ... Development Manager, Turf and Ornamental Products. , In his 15-year career with PBI-Gordon, Dave ... Herbicide Product Manager, where he was integral in the development and launch of many ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... state, but investors playing in this space know that volatility ... this morning,s featured companies on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: ... CTIC ), Lpath Inc. (NASDAQ: LPTN ), and ... now and gain access to the technical alerts for these ...
(Date:5/26/2016)... , May 26, 2016 Q BioMed ... it will be a featured presenter at the 5th Annual ... New York City at the Grand Hyatt ... , Q BioMed Inc. CEO, is scheduled to begin at ... the company,s business strategy, recent developments and outline milestones for ...
(Date:5/26/2016)... ... 26, 2016 , ... Kinder Scientific (KinderScientific.com), a leading animal ... the Company for the future. Kinder Scientific announces restructured ownership and additional ... appointed Chairman of the Board, Curtis D. Kinghorn has been appointed CEO/President and ...
Breaking Biology Technology: