Navigation Links
USC research determines apparent genetic link to prostate cancer in African-American men
Date:5/23/2011

Los Angeles, Calif., May 22, 2011Some men of African descent may have a higher genetic risk of developing prostate cancer, according to research conducted at the Keck School of Medicine of the University of Southern California (USC).

The genome-wide association study, published in the journal Nature Genetics on May 22, determined a marker of risk for prostate cancer in men of African descent, who tend to more susceptible to prostate cancer than men of non-African descent. The research team was led by Christopher Haiman, ScD., at the USC Norris Comprehensive Cancer Center and Hospital, part of the Keck School.

"This is a novel risk locus for prostate cancer, and the first study of its kind conducted in men of African ancestry," said Haiman, associate professor in the Keck School Department of Preventive Medicine. "We have been trying to figure out why African American men have a greater risk for prostate cancer. These findings may help us better understand if there is a genetic contribution to disparities in risk for this common cancer."

The research looked at common risk alleles for prostate cancer in men of African descent to determine a possible reason for the high incidence of prostate cancer in this population. The research focused on approximately one million single nucleotide polymorphism (SNP) markers across the genome of 3,425 African-American men with prostate cancer and 3,290 African-American male controls. The research turned up a novel risk variant on chromosome 17q21. The frequency of this marker is 5 percent in men of African ancestry but is rare in other populations.

The discovery builds on findings several years ago by Haiman's team of a risk region on chromosome 8q24, which also contains clues as to why more men in this population are likely to develop prostate cancer.

The findings support the need for additional genome-wide investigations to locate risk markers that are common or rare, which may play a role in racial and ethnic disease disparities, Haiman said.


'/>"/>

Contact: Leslie Ridgeway
leslie.ridgeway@usc.edu
323-442-2823
University of Southern California
Source:Eurekalert

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
(Date:11/17/2016)... Global Market Watch: Primarily supported by ... Banks and Academics) market is to witness a value of ... the highest Compounded Annual Growth Rate (CAGR) of 10.75% is ... analysis period 2014-2020. North America is ... Europe at 9.56% respectively. Report ...
(Date:11/14/2016)... -- xG Technology, Inc. ("xG" or the "Company") (Nasdaq: XGTI, ... use in challenging operating environments, announced its results for ... hold a conference call to discuss these results on ... below). Key Recent Accomplishments ... to acquire Vislink Communication Systems. The purchase is expected ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... , ... December 02, 2016 , ... Robots will storm ... on December 3rd, 2016. The event, which is held on the United Nations ... helping Americans with Disabilities back into the workplace. Suitable Technologies is partnering with NTI ...
(Date:12/2/2016)... world leader in rapid infectious disease tests, introduced the Company,s newest product, the INSTI ... (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) Continue Reading ... ... , bioLytical was invited by the Clinton ... HIV Self Test to 350 pharmacy representatives in Nairobi and ...
(Date:11/30/2016)... York , November 30, 2016 ... as a few players hold a dominant share in ... Charles River Laboratories International, Inc., and Merck KGaA, held ... in 2015. Transparency Market Research observes that these companies ... focused on development products that are do not require ...
(Date:11/30/2016)... SEATTLE , Nov. 30, 2016  The ... Allen Cell Collection: the first publicly available collection ... stem cells that target key cellular structures with ... Medical Research, these powerful tools are a crucial ... cells to better understand what makes human cells ...
Breaking Biology Technology: