Navigation Links
USC Stem Cell scientists lay a TRAP for disease
Date:7/11/2014

USC Stem Cell scientists have set a "mouse TRAP" to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs.

Invented by scientists at the Rockefeller Institute for Medical Research in 2008, TRAP involves attaching a fluorescent tag to the protein-making machinery, or ribosomes, of the cell type of interest. Scientists can then collect the tagged ribosomes and determine which active genes are ordering proteins to be made by these ribosomes. (TRAP stands for "translating ribosome affinity purification.")

Following up on this breakthrough, the USC team led by Jing Liu, senior research associate in the laboratory of Andy McMahon has made the technique simpler and more accessible by engineering a TRAP mouse. When bred with any one of thousands of existing strains of transgenic mice, the TRAP mouse produces progeny with tagged ribosomes in specific organs or cell types.

To demonstrate how useful this can be, Liu and her colleagues used TRAP mice to tag four different types of kidney cells and identify early signals of acute kidney injury.

As a consequence of surgery, infections or drug toxicity, five to seven percent of all hospitalized patients experience acute kidney injury, which can lead to chronic kidney disease or death.

Currently, doctors can only detect acute kidney injury a full day after it occurs. The TRAP mouse enables earlier detection, which will greatly improve patients' health.

"The technology is simple, and the kidney field is very excited about our results," said Liu. "I anticipate that the TRAP mouse will advance our cellular and molecular understanding of a wide variety of diseases and injuries in many different organ systems."


'/>"/>

Contact: Cristy Lytal
lytal@med.usc.edu
323-442-2172
University of Southern California - Health Sciences
Source:Eurekalert  

Page: 1

Related biology news :

1. Virtual finger enables scientists to navigate and analyze complex 3D images
2. Scientists watch photosynthesis in action
3. Scripps Florida scientists shed new light on nerve cell growth
4. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
5. Scientists discover clues why weight-loss surgery cures diabetes
6. CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms
7. Rockefeller scientists first to reconstitute the DNA replication fork
8. Scripps Florida scientists uncover new compounds that could affect circadian rhythm
9. US scientists dont publish articles about potential role of innate variation in athletic performance
10. Scientists can now screen for stem cells that enhance corneal regrowth
11. Clemson scientists: Kudzu can release soil carbon, accelerate global warming
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
USC Stem Cell scientists lay a TRAP for disease
(Date:9/18/2014)... Colo., USA A new GSA Bulletin ... the lower Rio Puerco and Chaco Wash in northern ... rings from salt cedar and willow, investigators were able ... or greater. They then combined this data with aerial ... the history of these arroyos. , Arroyos are deep, ...
(Date:9/18/2014)... ANTONIO, September 18, 2014 New research into the ... causes a severe hemorrhagic disease in humans similar to ... essential for CCHFV infection. This discovery has the potential ... the pathogen. , The research, reported in ... Pathogens and conducted by scientists at the Texas ...
(Date:9/18/2014)... the International Space Station ever starts a "frequent flyers" ... status. Recently the orbiting laboratory has hosted increasing numbers ... returned from the space station in April, and another ... third experiment is planned to launch in December. , ... around the world-- and in space. Model organisms can ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Research milestone in CCHF virus could help identify new treatments 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... has discovered that forest fragmentation poses an even greater ... , Their findings, to be published next week (27 ... National Academy of Sciences USA, summarizes key findings from ... fragmentation. , The Amazon contains the ...
... loses a chunk of its tail fin, it'll grow back ... can replace surprisingly complex body parts. A tail fin, for ... very intricate structure. It is the fish version of an ... re-grow missing tails and other appendages has fascinated veterinary and ...
... immune-boosting substance called an adjuvant, low doses of ... influenza (H9N2) provoked a strong antibody response in ... Institute of Allergy and Infectious Diseases (NIAID), part ... clinical trial of 96 adults was conducted at ...
Cached Biology News:Fragmentation rapidly erodes Amazonian biodiversity 2How does a zebrafish grow a new tail? 2How does a zebrafish grow a new tail? 3H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses 2
(Date:9/19/2014)... YORK , Sept. 19, 2014  An entire ... forms of inherited neuropathies – Charcot-Marie-Tooth disease (CMT) – ... and legs, causing extreme muscle atrophy, weakness, and foot ... the US and millions worldwide. CMT is a progressive ... of their legs, requiring mobility devices such as leg ...
(Date:9/19/2014)... Barnhardt Manufacturing Company has earned the ... Cotton . The USDA Certified Biobased Product Label verifies ... or exceeds levels set by USDA. Biobased products are ... significant part of agricultural, forestry, or marine ingredients. ... be immediately identified as a USDA certified BioPreferred ...
(Date:9/18/2014)... Washington, USA (PRWEB) September 18, 2014 ... Representatives of a bill designed to stimulate development and ... jobs is being praised by leaders of SPIE, ... bill, the Revitalizing American Manufacturing and Innovation (RAMI) Act, ... The bill’s authors have said they are optimistic that ...
(Date:9/18/2014)... -- Health Enhancement Products, Inc. (OTCQB: HEPI), a Michigan ... metabolic processes, is pleased to announce the addition of a ... Nola E. Masterson , a California -based ... 17, 2014. "We,re very pleased and honored ... Andrew Dahl , President and CEO. "She joins us ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2
... LAIYANG, China, Sept. 27 /PRNewswire-Asia-FirstCall/ -- ... ... ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first ...
... the specialist in genome customization and subsidiary of Cellectis ... its e-store, with approximately one hundred ready-to-use products available ... website. Launched in 2008, Cellectis bioresearch develops ... which offer a simple, effective means of using Cellectis ...
... Md., Sept. 24 Popular morning talk show LIVE! ... the show,s High Heel-a-thon, Wednesday morning in New York,s Central ... the Foundation for the National Institutes of Health (FNIH) in ... campaign for women,s heart health education and research. ...
Cached Biology Technology:Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 2Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 3Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 4Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 5Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 6Jiangbo Pharmaceuticals Announces Conference Call to Discuss Results for Fourth Quarter Fiscal 2010 7Cellectis Bioresearch Announces Availability of Research Kits Through New Online E-Store 2Cellectis Bioresearch Announces Availability of Research Kits Through New Online E-Store 3LIVE! With Regis and Kelly's 2010 'High Heel-A-Thon' Raises $63,000 for the Foundation for NIH 2LIVE! With Regis and Kelly's 2010 'High Heel-A-Thon' Raises $63,000 for the Foundation for NIH 3
... siSolutions siRNA Custom Synthesis Service ... duplex RNA to knockdown any ... (19 RNA base pairs with ... 27-mers, or other lengths of ...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
Hybridization cassette for one slide...
Request Info...
Biology Products: