Navigation Links
USC School of Dentistry researchers uncover link between osteoporosis drugs and jaw infection
Date:4/30/2008

A group of University of Southern California School of Dentistry researchers says it has identified the slimy culprits killing the jawbones of some people taking drugs that treat osteoporosis.

Microbial biofilms, a mix of bacteria and sticky extracellular material, are causing jaw tissue infections in patients taking bisphosphonate drugs, said Parish Sedghizadeh, lead researcher and assistant clinical professor at the USC School of Dentistry.

Sold under brand names such as Fosamax, Boniva and Actonel, bisphosphonates are prescribed to millions of patients to combat osteoporosis, a bone-wasting disease that increases the risk of fractures.

Sedghizadeh said there have been increasing reports of osteonecrosis (bone death) of the jaw in patients who have been taking the drugs for osteoporosis or for treatment from the bone-wasting effects of cancer. He said he decided to investigate further after seeing patients in USC dentistry clinics who had the unusual jaw infection.

This is the first study that identifies microbial biofilms in the bone of bisphosphonate patients who have osteonecrosis of the jaw, Sedghizadeh said.

Jaw osteonecrosis occurs when bacteria-laden biofilms infect the jaw after the bone is exposed, typically because of a tooth extraction or injury.

The USC research team includes renowned biofilm expert J. William Costerton, director of the Center for Biofilms at the USC School of Dentistry.

Pioneered by Costerton, biofilm theory has moved scientists beyond thinking of bacteria as free-floating organisms. Instead, bacteria build biofilm communities, attaching to surfaces and communicating and defending against antimicrobial invaders.

The team used powerful scanning electron microscopes to study patients jawbone samples. The images revealed biofilm bacteria sprawling over pitted tissue.

The scientists are now trying to determine why bisphosphonate drugs seem to open the door for biofilm-associated infections of the jaw.

Now that weve know biofilms are behind the infection of the jaw, we are studying ways to effectively treat or prevent the osteonecrosis, Sedghizadeh said.


'/>"/>

Contact: Angelica Urquijo
urquijo@usc.edu
213-740-6568
University of Southern California
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. Rutgers high school outreach gets $3 million boost from NSF
3. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
4. Folic acid lowers blood arsenic levels, according to Mailman School of Public Health study
5. UMass Medical School researchers receive $8.5M grant award to fight AIDS
6. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
7. Kids eat more fruits, vegetables when schools offer salad bar
8. CWRU School of Medicine has evidence vaccine against malaria will reduce disease
9. U. Mass Medical School and Carnegie announce licensing agreements with Oxford BioMedica
10. Cummings School receives Rockefeller Foundation grant
11. Iowa middle school wins IEEE-USA National Engineering Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Resoundant, Inc. is pleased ... centers around the U.S. that offer MR Elastography for liver fibrosis staging. ... biopsy for staging liver fibrosis assessment. , “MRE:connect was created in response to ...
(Date:7/20/2017)... ... July 20, 2017 , ... VIC Technology Venture Development™ (VIC™), ... of directors. This addition continues to strengthen and diversify VIC’s board. , "We ... Chairman. “He is a highly accomplished business executive with a broad range of experience ...
(Date:7/20/2017)... San Diego, CA (PRWEB) , ... July 20, 2017 , ... ... to corporate governance at its 27th annual Director of the Year Awards. , The ... Hyatt Regency La Jolla. This annual event celebrates directors who have made significantly ...
(Date:7/18/2017)... ... July 18, 2017 , ... Sourcing custom glass or ... needs and has the capabilities to properly execute your job can take many hours ... is a sourcing portal designed to showcase the company’s capabilities and core custom ...
Breaking Biology Technology: