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US Tox21 to begin screening 10,000 chemicals
Date:12/7/2011

h chemical analysis to verify its identity and determine its purity, concentration, and stability.

The goal of the testing is to provide results that will be useful for evaluating if these chemicals have the potential to disrupt processes in the human body to an extent that leads to adverse health effects.

The compounds will be tested in the Tox21 robotic screening system at the NCGC in Rockville, Md. The Tox21 robot, unveiled earlier this year, was purchased with funds provided by the NTP as part of its contribution to the Tox21 partnership.

"The robot has undergone rigorous testing since it was installed and unveiled earlier this year. It's ready to start testing this large compound library," said NHGRI Director Eric Green, M.D., Ph.D. "This is a milestone for Tox21, because it will allow us to test chemicals at a rate previously impossible for anyone to do by hand."

The development of methods for evaluating chemical toxicity has the potential to revolutionize the assessment of new environmental chemicals and the development of new drugs for therapeutic use.

"We are happy to contribute NCGC's pharmaceutical collection of approximately 3,500 compounds of approved and investigational drugs as part of the Tox21 program," said NCTT Scientific Director Christopher Austin, M.D. "Drug toxicity is one of the primary reasons that the development of new drugs fails and approved drugs are removed from the market, and the ability to better predict toxicity would improve the efficiency of drug development enormously."

The EPA seeks to understand the molecular basis of such chemicals to better protect human health and that of the environment.

"The Tox21 partnership integrates revolutionary advances in molecular biology, chemistry, and computer science, to quickly and cost-effectively screen the thousands of chemicals in use today," said Paul Anastas, Ph.D., assistant administrator of the EPA Office of Research
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Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

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